Towards a microRNA-based Johne's disease diagnostic predictive system: Preliminary results
Johne's disease, caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a chronic enteritis that adversely affects welfare and productivity in cattle. Screening and subsequent removal of affected animals is a common approach for disease management, but efforts are hindered by low diagnostic sensitivity. Expression levels of small non-coding RNA molecules involved in gene regulation (microRNAs), which may be altered during mycobacterial infection, may present an alternative diagnostic method.
Evidence-based use of biotics in the management of gastrointestinal disorders in dogs and cats
The gut microbiome plays a vital role in the overall health of dogs and cats, particularly their gastrointestinal (GI) health. Imbalances in the gut microbiome, termed dysbiosis, are associated with a range of GI disorders, including diarrhoea and chronic enteropathy. Emerging evidence tentatively supports the therapeutic use of pre-, pro- and postbiotics (collectively called biotics) to restore gut homeostasis and manage these conditions, especially due to their potential antibiotic-sparing effects. This article explores their evidence-based use in the treatment of GI disorders in dogs and cats.
Harnessing the microbiome: probiotics, antibiotics and their role in canine and feline gastrointestinal disease
Unfavourable alterations of the host microbial environment, known as dysbiosis, have been identified in many canine and feline gastrointestinal (GI) diseases. As a result, normalisation of microbial composition and function has become an important therapeutic target. Given the complex and individualistic interplay between the resident microbiota, host and environment, a multimodal approach is often necessary when addressing dysbiosis in dogs and cats with GI disease. Systemic antibiotics are often empirically used to treat acute and chronic GI diseases. However, with modern genomic techniques demonstrating the profound negative effect antibiotics can have on the GI microbiota and the rapid emergence of resistant bacteria globally, there has been an increased focus on identifying antibiotic alternatives for use in small animal practice. Biotics, such as prebiotics, probiotics and synbiotics, are of growing interest due to their potential supportive effect on the microbiota. This article reviews the evidence for the use of biotics in canine and feline GI disease, highlighting how judicious use of antibiotics and targeted probiotic supplementation can enhance patient outcomes by promoting a balanced gut microbial environment.
UK animal therapists' confidence in executing professional skills in clinical practice
Veterinary physiotherapy and hydrotherapy are popular modalities in the UK, yet little is known about the confidence of therapists responsible for performing these treatments. A lack of confidence may have a detrimental impact on patients; therefore, this study investigated the effect of age, species specialisation, educational level, occupation, qualifications, experience and years practising on animal therapists' confidence in executing professional skills.
Medial joint line tenderness is an indicator for meniscal injuries in dogs
Medial meniscal injury is an important aspect of cranial cruciate ligament disease in dogs. This study examines whether caudomedial joint line palpation of the stifle is correlated with medial meniscal injury in canine stifles with concurrent cranial cruciate ligament disease.
Validation of a reduction in time for avian influenza virus isolation using specific pathogen-free embryonated chicken eggs
The international gold standard for avian influenza virus (AIV) diagnosis is virus isolation (VI) in specific pathogen-free embryonated chicken eggs (ECEs). AIV isolation typically involves a 6-day turnaround, during which premises under suspicion for notifiable AIV infection are held under restriction regardless of molecular diagnoses, often with significant welfare implications.
Stephen Raymond Bicknell
After completing National Service as a vet in Singapore, he worked in practice before joining the State Veterinary Service. In retirement, he enjoyed many hobbies and helping others.