Research in Autism Spectrum Disorders

Effects of Creative Movement, General Movement, or Seated Play Interventions on Motor Performance in Children with Autism Spectrum Disorder: A Pilot Randomized Controlled Trial
Su WC, Srinivasan S and Bhat AN
Children with ASD experience significant gross motor challenges that could be addressed using motor interventions. However, contemporary ASD interventions that are sedentary in nature often target communication and fine motor skills and not children's gross motor difficulties.
Exploring social cognition and romantic self-efficacy in autistic young adults: Better social awareness is associated with lower confidence
Schichter I, Nadwodny N, Kohn BH, Thakkar D, Pantalone DW and Faja S
Despite misconceptions, autistic young adults are interested in romantic relationships (Fernandes et al., 2016; Hancock et al., 2019; Mehzabin & Stokes, 2011). Research is needed to better understand how the social characteristics of autism impact romantic relationship experiences, knowledge of sexual health, and confidence in one's own abilities. Social cognition skills are linked to functioning in interpersonal relationships and are important for understanding the mental states of others. The present research aims to explore the intersections among social cognition skills, romantic self-efficacy, perceived knowledge, and dating outcomes. We hypothesize that social cognition skill level, self-efficacy, perceived knowledge, and romantic relationship outcomes will be positively related.
The Effects of the COVID-19 Pandemic on Mental Health in Mothers of Autistic Children and Mothers of Children with Fragile X Syndrome
Moser C, Friedman L, Bangert K, Hickey A, Sun J and Klusek J
The COVID-19 pandemic adversely affected the mental health of American mothers and mothers of children with disabilities may have been disproportionately impacted. The present study characterized psychological well-being, social support, and caregiving responsibilities during the pandemic across mothers of children with autism, fragile X syndrome (FXS), and neurotypical children.
"Education would be step number one": Community mental health clinicians' training and support needs to treat anxiety in autistic youth
LaPoint SC, Simmons GL, Heinly J, Delgado D, Shepherd WS, Brookman-Frazee L, Storch EA and Maddox BB
Autistic youth experience high rates of anxiety, which has been treated with modified cognitive-behavioral therapy (CBT), often integrating exposure therapy. Such anxiety treatments are effective for this population; however, there remains a gap between these evidence-based mental health interventions and their implementation in community mental health (CMH) services where autistic youth receive care.
Correlates of Quality of Life in Autistic Individuals
MacKenzie KT, Theodat A, Beck KB, Conner CM, Mazefsky CA and Eack SM
Quality of life is an important outcome to autistic individuals. However, the correlates of quality of life in this population are not well known. The purpose of this project was to investigate the extent to which employment, depression, anxiety, and social participation were associated with quality of life in autistic individuals. We also explored potential associations between emotion dysregulation and quality of life.
An Exploratory Study of Resilience to Stressful Life Events in Autistic Children
Greenlee JL, Putney JM, Hickey E, Winter MA and Hartley SL
Autistic children experience more stressful life events (SLEs) than their neurotypical peers, which are related to poor mental health outcomes in both neurotypical and autistic individuals. However, there is a lack of longitudinal research assessing the perceived impact of stressful life events on autistic children's mental health.
Autistic traits in adolescents in psychiatric inpatient care: Clinical and demographic characteristics and correlates
Schwartzman JM and Bettis AH
Rates of psychiatric hospitalization among adolescents in the United States are rising, with many adolescents presenting to these settings with diverse clinical presentations, including autistic traits. To our knowledge, there has been little research identifying clinical characteristics of adolescents with autistic traits admitted to psychiatric inpatient units, which may be leveraged to improve assessment and treatment practices.
Social Context in Stress and Autism: Comparing Physiological Profiles Across Two Social Paradigms in Youth with and without Autism Spectrum Disorder
Muscatello RA, McGonigle T, Simon V and Blythe A C
The social world is often stressful for individuals with autism spectrum disorder (ASD). Research shows youth with ASD demonstrate physiological hyperreactivity to some social stressors (e.g., interaction) but not others (e.g., evaluation); therefore, this study examined diagnosis (ASD or typical development (TD)), social context, perceived anxiety, and physiological responsivity across multiple stress systems; namely, the hypothalamic pituitary adrenal (HPA) axis and autonomic nervous system (ANS).
Similar overall expression, but different profiles, of autistic traits, sensory processing, and mental health between young adult males and females
Cardon G, McQuarrie M, Calton S and Gabrielsen TP
Recent trends suggest that autism is more common in females than traditionally held. Additionally, some argue that females express autistic traits differently than males. Dimensional views of autism could shed light on these issues, especially with regards to understudied behavioral areas, such as sensory processing. We examined autistic traits, sensory processing, anxiety, and related behaviors in a large sample of neurotypical young adult males and females ( = 1,122; 556 female; ages 19-26). Participants completed an online survey containing questionnaires related to the above. Between groups statistical analyses, as well as within groups correlations and mediation analyses containing these constructs were then computed. We also carried out a cluster analysis to establish groups with behavioral similarities and estimate within-cluster male/female ratios. Results showed modest differences in the overall expression of autistic traits and sensory processing, if any, between males and females. Conversely, more detailed examination of survey subtests and mediation analyses revealed differing profiles between these groups. Cluster analysis uncovered a group comprised of both males (69.8%) and females (30.2%) who exhibited elevated degrees of autism-related behaviors, suggesting a higher proportion of females than would be predicted by traditional ratios. Taken together, these findings suggest that males and females may not differ as much as previously thought in their general levels of autistic traits or sensory processing, but may present with distinct profiles of such behaviors. These novel results add to our understanding of autistic traits in females and have the potential to positively influence diagnostic and support practices.
Remote vs. In-person Schooling during the COVID-19 Pandemic and Internalizing Symptoms among Children on the Autism Spectrum
Courreges A, Kouros CD, Ekas NV and Levy S
Children on the autism spectrum encountered interruptions to their education due to the COVID-19 pandemic (White et al., 2021). This study examined the extent to which autistic children's anxiety and depressive symptoms during the pandemic were associated with the school format they attended in October 2020 (remote, in-person/hybrid, homeschool), controlling for their pre-pandemic symptoms. Pre-pandemic peer victimization and autism symptom characteristics were tested as moderators.
Barriers to an Autistic Identity: How RRBs may Contribute to the Underdiagnosis of Females
Cary E, Rao A, Matsuba ESM and Russo N
Autistic females are frequently underdiagnosed, misdiagnosed, and/or diagnosed later in life. Restricted and Repetitive Behaviors (RRBs) are increasingly critical for diagnosis and yet are commonly rated lower in females. Whether this reflects genuinely lower levels of these traits, or if female-typical RRBs have a different phenotypic presentation that may not register on current quantitative measurement tools is unclear.
Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data
DiCriscio AS, Beiler D, Smith J, Asdell P, Dickey S, DiStefano M and Troiani V
Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort.
Pragmatic language and associations with externalizing behaviors in autistic individuals and those who have lost the autism diagnosis
Crutcher J, Butler E, Burke JD, Naigles L, Fein DA and Inge-Marie E
Pragmatic language weaknesses, a core feature of autism spectrum disorder (ASD), are implicated in externalizing behavior disorders (Gremillion & Martel, 2014). Particularly in a clinical setting, these co-occurring externalizing disorders are very common in autism; rates of Attentional Deficit-Hyperactive Disorder (ADHD) and Oppositional Defiant Disorder (ODD) are as high as 83% (ADHD) and 73% (ODD; Joshi et al., 2010). It is possible that pragmatic language weaknesses impact the ability to effectively communicate one's needs, which may lead autistic children to utilize externalizing behaviors in order to achieve a desired outcome (Ketelaars et al., 2010; Rodas et al., 2017).
Uncertainty, Sensory Processing, and Stress in Autistic Children During the COVID-19 Pandemic
Cardon G and Bradley M
COVID-19 increased uncertainty for most and was especially disruptive to autistic people and their families, due in part to tendencies toward intolerance for uncertainty across this population. As such, COVID presented a natural experiment of uncertainty and its correlates in autism. Previous reports have shown associations between intolerance of uncertainty, sensory difficulty, and stress.
Measuring Dyspraxia in Autism using a Five-Minute Praxis Exam
de Marchena A, Zampella CJ, Dravis Z, Pandey J, Mostofsky S and Schultz RT
Difficulties with the ability to perform learned skilled movements, have been robustly demonstrated in autism spectrum disorder (autism). However, praxis assessment is not routinely included in autism characterization batteries, in part because it is traditionally time consuming to administer and score. We test whether dyspraxia in autism can be captured with a brief measure.
Exploring Bidirectional Relationships: Child Sleep Duration, Child Behavior Problems, and Parenting Stress in Families of Children with Autism Spectrum Disorder
Iwamoto BK, Neece CL, Nair A, Rockwood NJ, Fenning RM, Krantz ML and Van Dyk TR
Youth with Autism Spectrum Disorder (ASD) are at-risk for sleep and behavior problems, and their parents are at-risk for high stress. Child sleep duration, behavior problems, and parenting stress are interrelated; however, directionality of these associations is unclear and research including youth with ASD is lacking. Using a day-to-day, within-person design, this study explores the directionality of these relationships in families of children with ASD.
The impact of COVID-19 on sleep for autistic children: A systematic review
Lewis S, Papadopoulos N, Mantilla A, Hiscock H, Whelan M, McGillivray J and Rinehart N
Up to 80% of children with autism experience behavioural sleep problems, predominantly relating to bedtime resistance, sleep anxiety, sleep dysregulation, and shorter duration, which are associated with increased autistic symptom expression and emotional and behavioural difficulties. Researchers predicted the COVID-19 pandemic would worsen sleep and behavioural difficulties for autistic children, due to their need for routine and certainty. This systematic review is the first to focus on delineating the role of sleep disturbance in exacerbating autistic symptoms and internalising and externalising behaviours during the pandemic.
Differences in speech articulatory timing and associations with pragmatic language ability in autism
Lau JCY, Losh M and Speights M
Speech articulation difficulties have not traditionally been considered to be a feature of Autism Spectrum Disorder (ASD). In contrast, speech prosodic differences have been widely reported in ASD, and may even be expressed in subtle form among clinically unaffected first-degree relatives, representing the expression of underlying genetic liability. Some evidence has challenged this traditional dichotomy, suggesting that differences in speech articulatory mechanisms may be evident in ASD, and potentially related to perceived prosodic differences. Clinical measurement of articulatory skills has traditionally been phoneme-based, rather than by acoustic measurement of motor control. Subtle differences in articulatory/motor control, prosodic characteristics (acoustic), and pragmatic language ability (linguistic) may each be contributors to differences perceived by listeners, but the interrelationship is unclear. In this study, we examined the articulatory aspects of this relationship, in speech samples from individuals with ASD and their parents during narration.
Here's the Story: Narrative Ability and Executive Function in Autism Spectrum Disorder
Greco G, Choi B, Michel K and Faja S
Difficulties with narrative have been reported in individuals diagnosed with autism spectrum disorder (ASD), but the role of executive function on narrative ability has not been examined in ASD. In this study, we aimed to (1) examine whether narrative abilities of ASD children differed from neurotypical (NT) children who did not differ in age, sex, and IQ; and (2) investigate relations between executive function and narrative ability in ASD children.
Emotion Regulation and Executive Function: Associations with Depression and Anxiety in Autism
Conner CM, Elias R, Smith IC and White SW
Adolescents and young adults with autism spectrum disorder (ASD) are prone to experience co-occurring mental health conditions such as mood or anxiety disorders, as well as impairments in emotion regulation and executive functioning. However, little research has examined inter-relationships among these constructs, despite evidence of additional stressors and increased risk of internalizing disorders at this age, relative to non-autistic individuals. If either emotion regulation or executive functioning are shown to have patterns of association with mental health, this can inform mechanism-based intervention.
Mortality rate and age of death among Medicare-enrolled autistic older adults
Krantz M, Dalmacy D, Bishop L, Hyer JM and Hand BN
An emerging body of evidence suggests that autistic people are at greater risk for mortality than non-autistic people. Yet, relatively little is known about mortality rates among autistic people during older adulthood (i.e., age 65 or older).
A Scoping Review of Behavioral Interventions for Promoting Social Gaze in Individuals with Autism Spectrum Disorder and Other Developmental Disabilities
Hustyi KM, Ryan AH and Hall SS
Individuals diagnosed with autism spectrum disorder (ASD) commonly experience difficulties maintaining social gaze with others during interactions. Although behavioral interventions targeted to promote social gaze in ASD are evident in the literature, to our knowledge, no review of the literature has been conducted to summarize and evaluate the evidence for these interventions.
Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study
Granillo L, Iosif AM, Goodrich A, Snyder NW and Schmidt RJ
Maternal hormonal risk factors for autism spectrum disorder (ASD) in offspring could intersect genetic and environmental risk factors.
Video-based screening for children with suspected autism spectrum disorder - experience during the COVID-19 pandemic in India
Kadam A, Soni IG, Kadam S, Pandit A and Patole S
Assessments for children with autism spectrum disorder (ASD) must adapt to the current COVID-19 pandemic through innovation in screening and assessment strategies using technology. To our knowledge there are no such studies reported from India. We aimed to study the predictive ability of video-based screening tool with definitive diagnosis in children with ASD.
Characterizing difficulties with emotion regulation in toddlers with autism spectrum disorder
Day TN, Mazefsky CA and Wetherby AM
Difficulties with emotion regulation (ER) underlie emotional/behavioral challenges and co-occurring psychiatric symptoms in autism spectrum disorder (ASD), yet very little is known about the early development of emotion dysregulation. The present study aimed to identify differences in positive and negative emotional reactivity and regulation strategies in toddlers with and without ASD.
Characteristics associated with healthcare independence among autistic adults
Longo A, Gilmore D, Garvin J, Hyer JM, Coury D, Hanks C, Moffatt-Bruce S, Hess A and Hand BN
Healthcare independence refers to someone's ability to assume responsibility for their own health and complete tasks like taking medication as prescribed or scheduling healthcare appointments. Prior studies have shown that autistic people tend to need more support with healthcare tasks than people with other chronic conditions. We sought to identify modifiable and non-modifiable factors linked with healthcare independence among autistic adults.
Effects of Sex, Race, and Ethnicity on Primary and Subspecialty Healthcare Use by Autistic Children in Florida: A Longitudinal Retrospective Cohort Study (2012-2018)
Angell AM, Varma DS, Deavenport-Saman A, Yin L, Solomon O, Bai C and Zou B
Pragmatic Language Markers of Autism Diagnosis and Severity
Dolata JK, Suarez S, Calamé B and Fombonne E
Assessment of pragmatic language difficulties is limited with conventional tests but can be performed with informant reports. We evaluated the performance of a parent-completed language scale in differentiating autism from typical development (TD) and another neurodevelopmental disorder. Specifically, we aimed to gauge the respective values of structural and pragmatic language scores for diagnostic discrimination and for predicting severity of social impairment in autistic children.
Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder
Heller Murray ES, Segawa J, Karahanoglu FI, Tocci C, Tourville JA, Nieto-Castanon A, Tager-Flusberg H, Manoach DS and Guenther FH
Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task.
Brief report: Parent-guided movements during play with children with autism spectrum disorder
Yamane N, Snow AD, Fein D, Naigles L and Goldman S
Children with autism spectrum disorder (ASD) demonstrate social and communication impairments from an early age. While researchers have long investigated parenting behaviors in relation to children's social and communication development, fewer studies have examined the relevance of movement-based parenting behaviors to facilitating communication and social engagement with young children. The present study aimed to investigate: (1) parent-guided movements (PGMs) within dyads of parents and typically developing (TD) children and children with ASD; and (2) children's ASD diagnostic and receptive language scores as predictors of PGM frequency.