The preparation of polyaniline (PANI) and its copolymer with indole involved a chemical oxidative polymerization method, with benzene sulfonic acid (BSA, CHOS) used as a dopant and potassium persulfate (PPS, KSO) as an oxidant. The synthesized compounds underwent characterization using FTIR, 1H-NMR, TGA, and GPC techniques, which allowed the calculation of their average molecular weight and polydispersity index (PDI) through the GPC technique. The PDI values of the PANI copolymer with indole in different aniline-to-indole ratios were 1.53, 1.13, and 1.532 for 1:1, 1:2, and 2:1 ratios, respectively. Thermal stability was determined using TGA, revealing that the indole heterocyclic compound increased the inflexibility of the polymer chains in the synthesized PANI copolymer. The structure of the copolymer was further analyzed using HNMR and FTIR techniques, which confirmed the existence of benzenoid and quinoid groups in the PANI-indole copolymers, as well as the effect of doping on the polymer chains. The antibacterial and antifungal properties of the copolymers were studied against several bacterial and fungal strains and measured in terms of minimum inhibitory concentration. Results indicated that the inhibition rate of the PANI-indole copolymer on (MTCC 442) was higher than that of standard drugs and individual PANI. The PANI-indole copolymers also displayed excellent antituberculosis and antimalarial activities, with the synthesized copolymer showing better outcomes than individual PANI.

Protection in many service areas is mandatory for good performance in daily activities of workers, especially health areas. Personal protective equipment (PPE) is used to protect patients and health workers from contamination by harmful pathogens and body fluids during clinical attendance. The pandemic scenario caused by SARS-CoV-2 has shown that the world is not prepared to face global disease outbreaks, especially when it comes to the PPE of healthcare workers. In the last years, the world has faced a deficiency in the development of advanced technologies to produce high-quality PPE to attend to the exponential increasing demand. Electrospinning is a technology that can be used to produce high-quality PPE by improving the protective action of clothing. In the face of this concern, this manuscript presents as focus the potential of electrospinning to be applied in protective clothing. PPE mostly used by healthcare workers are also presented. The physico-chemical characteristics and production processes of medical textiles for PPE are addressed. Furthermore, an overview of the electrospinning technique is shown. It is important to highlight most research about electrospinning applied to PPE for health areas presents gaps and challenges; thus, future projections are also addressed in this manuscript.

Molecularly imprinted polymers (MIPs) have attracted much attention in recent years due to their structure predictability, recognition specificity, and universal application, as well as robustness, simplicity, and cheapness. In this study, firstly, the pre-polymerization process of molecularly imprinted polymer of dipicolinic acid (DPA) was simulated by molecular dynamics. Then, the appropriate functional monomer molecule for printing was selected and its intermolecular bond with the DPA molecule was evaluated. The monomers 2-vinyl pyridine, acrylic acid (AA), and methacrylic acid (MAA) were selected with potential energies of 3.93 kcal/mol, 3.15 kcal/mol, and 2.78 kcal/mol, respectively. Finally, the ability of functional groups to form hydrogen bonds was estimated, and molecularly imprinted polymers (MIPs) and non-imprinted polymers (NIPs) were synthesized by bulk polymerization. MAA and AA were used as functional monomers to identify DPA molecules. The morphology of MIP and NIP was investigated using a scanning electron microscope (SEM). Their performance was evaluated in the absorption of DPA molecules and picolinic acid (PA) molecules and the printing factor of synthesis polymers. The results showed that fabricated MIPs can be used in the structure of sensors, and the synthesis process is a key factor that significantly affects the polymer properties. The MIP based on the AA monomer showed a higher adsorption rate/capacity and maximum printing factor than MAA monomer-based MIP.

Infectious diseases and their effective management are still a challenge in this modern era of medicine. Diseases, such as the SARS-CoV-2, Ebola virus, and Zika virus, still put human civilization at peril. Existing drug banks, which include antivirals, antibacterial, and small-molecule drugs, are the most advocated method for treatment, although effective but they still flounder in many instances. This calls for finding more effective alternatives for tackling the menace of infectious diseases. Nanoformulations are progressively being implemented for clinical translation and are being considered a new paradigm against infectious diseases. Natural polymers like chitosan are preferred to design nanoparticles owing to their biocompatibility, biodegradation, and long shelf-life. The chitosan nanoparticles (CNPs) being highly adaptive delivers contemporary prevention for infectious diseases. Currently, they are being used as antibacterial, drug, and vaccine delivery vehicles, and wound-dressing materials, for infectious disease treatment. Although the recruitment of CNPs in clinical trials associated with infectious diseases is minimal, this may increase shortly due to the sudden emergence of unknown pathogens like SARS-CoV-2, thus turning them into a panacea for the management of microorganisms. This review particularly focuses on the all-around application of CNPs along with their recent clinical applications in infectious disease management.

Estimating the number of COVID-19 cases in 2020 exacerbated the food contamination and food supply issues. These problems make consumers more concerned about food and the need to access accurate information on food quality. One of the main methods for preserving the quality of food commodities for export, storage, and finished products is food packaging itself. In the food industry, food packaging has a significant role in the food supply which acts as a barrier against unwanted substances and preserves the quality of the food. Meanwhile, packaging waste can also harm the environment; namely, it can become waste in waterways or become garbage that accumulates because it is nonrenewable and nonbiodegradable. The problem of contaminated food caused by product packaging is also severe. Therefore, to overcome these challenges of safety, environmental impact, and sustainability, the role of food packaging becomes very important and urgent. In this review, the authors will discuss in more detail about new technologies applied in the food industry related to packaging issues to advance the utilization of Smart Packaging and Active Packaging.

Biodegradable polymers have emerged as fascinating materials due to their non-toxicity, environmentally benign nature and good mechanical strength. The toxic effects of non-biodegradable plastics paved way for the development of sustainable and biodegradable polymers. The engineering of biodegradable polymers employing various strategies like radical ring opening polymerization, enzymatic ring opening polymerization, anionic ring opening polymerization, photo-initiated radical polymerization, chemoenzymatic method, enzymatic polymerization, ring opening polymerization and coordinative ring opening polymerization have been discussed in this review. The application of biodegradable polymeric nanoparticles in the biomedical field and cosmetic industry is considered to be an emerging field of interest. However, this review mainly highlights the applications of selected biodegradable polymers like polylactic acid, poly(-caprolactone), polyethylene glycol, polyhydroxyalkanoates, poly(lactide-co-glycolide) and polytrimethyl carbonate in various fields like agriculture, biomedical, biosensing, food packaging, automobiles, wastewater treatment, textile and hygiene, cosmetics and electronic devices.

With ,'-methylenebisacrylamide (MBA) and polyvinyl alcohol (PVA) as raw materials, a polymer (PVA-MBA) containing -halamine precursor functional groups was obtained via grafting reaction between the active hydroxyl groups on PVA and , -unsaturated functional groups of MBA under the catalysis of sodium carbonate in an aqueous solution. An acyclic -halamine precursor-grafted PVA (MBA-PVA) film was formed by simply spreading PVA-MBA aqueous solution in a glass dish and drying it. An antimicrobial acyclic -halamine-grafted PVA (PVA-MBA-Cl) film was achieved by spraying the diluted sodium hypochlorite solution onto the surface of PVA-MBA film. The performance test of PVA-MBA-Cl film under the optimal preparation conditions showed that the tensile performance and the hydrophobicity were improved, compared to the PVA film. The storage stability test indicated that the oxidative chlorine content Cl (atoms/cm) of the as-prepared PVA-MBA-Cl film only reduced by 14.3% after storage for 9 weeks, showing that the antibacterial -halamine functional groups in PVA-MBA-Cl film has excellent storage stability under room temperature. Antibacterial test showed that the PVA-MBA-Cl film had very strong antibacterial efficacies and could completely kill 1.28 × 10 CFU/mL and 1.89 × 10 CFU/mL within 1 min. Therefore, PVA-MBA-Cl film will have more potential applications in food package.

Starch-based foams can be used in packaging development to replace nonbiodegradable petrochemical plastics. However, starch-based materials possess poor mechanical properties and low water resistance. These properties can be improved by adding plasticizers and fillers to the bulk composition. In the present work, the effect of rice husk ash content on physical, morphological, and mechanical properties of cassava starch-based foams produced by thermal expansion was investigated. The composites were formed by mixing cassava starch, rice husk ash (content varying from 0 to 60%), water, and glycerol. The obtained dough was placed in a metallic mold and then expanded in a thermohydraulic press machine. The addition of 20-50% of ash content improved thermal stability, density, and biodegradation of starch-based foams and decreased water absorption capacity. Filled starch-based foams also exhibited smaller pores in internal structure. Compared to foams without ash filler, the addition of 20-40% ash increased the flexural tensile strength and the addition of more than 50% dropped the mechanical resistance. Hence, based on the results obtained, rice husk ash can be a great filler in biodegradable starch-based foams.

In 2020, Coronavirus disease (COVID-19), a new viral respiratory disease caused by a virus that belongs to family, has been identified. It is a very severe flu that negatively affects the functions of the lung and other respiratory organs. COVID-19 virus can be transmitted between people either by touching an infected person or by direct contact with their respiratory droplets. Therefore, the COVID-19 virus has become a global concern due to its rapid spread and severity. Based on the World Health Organization report from 2 March 2020 to 24 October 2022, the total infected cases and deaths in Morocco are around 1,265,389 (3.46%) and 16,280 (0.04%), respectively. Recently, some scientists have found that chitosan, a polymer existed in nature, can inhibit COVID-19 infection and repair damaged tissue. Therefore, understanding chitosan mechanisms in controlling COVID-19, might lead to innovative strategies in the medical field, such as developing drugs against SARS-CoV-2, and replacing vaccines, which have negative side effects. This review aims to show the evolution of the COVID-19 pandemic worldwide, specifically in Morocco, its pathophysiology, and its ability to silence the immune system. This review also provides an overview of the treatments and measures applied to protect human beings and how chitosan acts and controls COVID-19.

The use of active packaging has attracted considerable attention over recent years to prevent and decrease the risk of bacterial and viral infection. Thus, this work aims to develop active packaging using a paper coated with green-synthesized silver nanoparticles (AgNPs). Effects of different silver nitrate (AgNO) concentrations, viz. 50, 100, 150, and 200 mM (AgNPs-50, AgNPs-100, AgNPs-150, and AgNPs-200, respectively), on green synthesis of AgNPs and coated paper properties were investigated. A bio-reducing agent from mangosteen peel extract (ex-Garcinia mangostana (GM)) and citric acid as a crosslinking agent for a starch/polyvinyl alcohol matrix were also used in the synthetic process. The presence of AgNPs, ex-GM, and citric acid indicated the required synergistic antibacterial activities for gram-positive and gram-negative bacteria. The paper coated with AgNPs-150 showed complete inactivation of virus within 1 min. Water resistance and tensile strength of paper improved when being coated with AgNPs-150. The tensile strength of the coated paper was found to be in the same range as that of a common packaging paper. Result revealed that the obtained paper coated with AgNPs was proven to be effective in antibacterial and antiviral activities; hence, it could be used as an active packaging material for items that require manual handling by a number of people.

Growing natural calamities as a consequence of global warming are one of the most pondering subjects today. The exponential growth of environmental pollution due to unscientific human exploitation of natural resources is considered the prime reason for the harsh responses of nature. Researchers from various fields of industry and academia are working hard to develop and implement products/technologies that are environmentally friendly or less harmful to the ecosystem. Material researchers, specifically those working in the automobile sector are also not behind in search of green products from eco-friendly raw materials and production methods. The automobile industry is collectively responsible for around 40% of global pollution in terms of greenhouse gas emissions. Out of which around 20-30% is originating from tyre production and its end-use. In this view, tyre production from eco-friendly raw materials and technologies that have minimum hazardousness to the environment is a hot research topic today. A few products in the market with "green" tags and many are in the pipeline for the recent future. This review summarises a detailed discussion of the emerging green technologies for tyre production and depicted comprehensive data from the available literature. The paper has been drafted from a well-balanced academic and industrial point of view since the researchers from both sectors are working in harmony for a better future for green tyre technology.

Virus-caused public health outbreaks represent a serious threat to humans all over the world. The rampant new 2019 coronavirus (SARS-CoV-2) has wreaked havoc on China and the rest of the world since December 2019. Now focus is on effective reduction of corona and other viral and bacterial infections in hospitals, public and private sectors, households, schools, etc. Metal and metal oxide nanoparticles, carbon nanotubes, heterostructures, patterned surfaces, and graphene-based materials have shown up to 99.9998% efficacy against bacteria, mold, and viruses. The stability, long shelf life, and robustness of inorganic nanoparticles make them desirable for antimicrobial nanofinishes. These inorganic antimicrobial agents are more stable than organic antibacterial compounds at high temperature and pressure. The high specific surface area-to-volume ratios and unique physicochemical characteristics of nanoparticles are largely responsible for their antibacterial actions. But their immobilization is a huge challenge. To address this issue, NPs were modified with (glycidoxypropyl) trimethoxysilane (GPTS) and applied on cotton fabric. The silane part of GPTS reacted with the NPs under acidic conditions while epoxy reacted with cotton under alkaline conditions. Treated cotton fabric showed good antiviral and antibacterial activity even after severe industrial washing.

Polyurethane is a versatile material that can be converted into various forms according to applications. PU foams or PUFs are the most commonly used polyurethanes. These are materials of low density and low thermal conductivity that make them highly suitable for thermal insulating applications. Most of the synthesis of PUFs is still based on the petrochemical industry. There are issues associated with the oil industry, such as environmental pollution, sustainability, and market instability. More recently, we have experienced the COVID-19 pandemic which has destroyed the global supply chain of raw materials. Such sudden disruption of the supply chain affects the global economy. To eliminate the reliance on special ingredients, it is important to find and produce alternate and domestic raw materials. Vegetable oils are organic, cost-effective, and economically viable and present in abundant amounts. The oil consists of triglycerides. It can be functionalized to provide polyol for PU foam synthesis. Herein, we review the literature on factors influencing the properties of PUFs depending on polyols from vegetable oil as well as present a glimpse of the conversion of vegetable oils into polyols for PUF synthesis.

Flavonoids are present naturally in many fruits and vegetables including onions, apples, tea, cabbage, cauliflower, berries and nuts which provide us with quercetin, a powerful natural antioxidant and cytotoxic compound. Due to antioxidant property, many nutraceuticals and cosmeceuticals products contain quercetin as a major ingredient nowadays. Current review enlightened sources and quercetin's role as an antioxidant, antimicrobial, antidiabetic, anticancerous and anti-inflammatory agent in medical field during last 5 to 6 years. Literature search was systematically done using scientific for the published articles of quercetin. A total of 345 articles were reviewed, and it was observed that more than 40% of articles were about quercetin's use as an antioxidant agent, more than 25% of studies were about its use as an anticancer agent, and articles on antimicrobial activity were more than 15%. 10% of the articles showed anti-inflamamatory effects of quercetin. Literature search also revealed that quercetin alone and its complexes with chitosan, metal ions and polymers possessed good antidiabetic properties. Thus, the review focuses on new therapeutic interventions and drug delivery system of quercetin in medical field for the benefit of mankind.

Natural fibres such as coir, jute, flax, and hemp have been considered for technical applications. These fibres, though with some desirable qualities such as low density and environmental compatibility, possess the common property of non-uniformity along their length and, as a result, variable diameter and variable cross-sectional area. Several other factors, such as gauge length, fibre species and origin, strain rate, method of extraction of the fibres, porosity and pore size distribution, have been identified to influence the tensile strength of natural fibres and limit their applications in composites. Besides, several authors have used different diameters for the same type of natural fibre, such as coir, resulting in significant inconsistency in the tensile properties. For the same type of coir fibre, and from tensile strength reports from ten authors, an average tensile strength of 120.97 ± 42.30 MPa was obtained. The average number of fibres used in most cases for the tensile test was less than the requirement for natural fibres. All these factors were addressed with the aim of improving the overall properties of natural fibres and their composites.

The density functional theory calculation has been carried out for the analysis of 5-chlorouracil using DFT/Gaussian 09 with GAR2PED. Recorded experimental spectra for Raman and IR of 5-chlorouracil have been analyzed all fundamental vibrational modes using the outcome results of DFT at 6-311++G** of Gaussian 09 calculations and the GaussView 5.09. To help the analysis of vibrational modes, GAR2PED program has been used in the calculation of PEDs. The charge transfer properties of 5-chlorouracil have been analyzed using HOMO and LUMO level energy analysis. HOMO and LUMO energy gap study supports the charge transfer possibility in molecule. These have been made to study for reactivity and stability of for the analysis of antiviral drugs against the new corona virus: COVID-19. Here, the of 5-chlorouracil is more responsible for charge transfer interaction in the and a reason of more bioactivity. The electron density mapping within molecular electrostatic potential plot and electrostatic potential plotting within iso-surface plot have been evaluated the charge distribution concept in the molecule as the nucleophilic reactions and electrophilic sites. These computations have been used to produce the molecular charges, structure and thermodynamic functions of biomolecule. This study has been made to all internal modes of chloro group substituent at pyrimidine ring of C atom. The splitting of frequencies has arisen in the two species for the normal distribution modes.

Functional cotton fabrics using silver-based nanoparticles (AgNPs) have attracted a lot of attention as a new generation of healthcare wearable textile. In this study, cotton fabrics were coated via impregnation with silver nanoparticles using chitosan (Cs) and (or) chitosan-organosilica (Cs-OSH) solutions as adhesives matrices. The physicochemical properties were studied using UV-VIS spectroscopy, and transmission electron microscopy (TEM) and scanning electron microscope coupled with energy-dispersive X-ray spectroscopy methods (SEM-EDX). The antibacterial activity of the silver-treated fabrics was determined using agar diffusion method. However, nanosize spherical AgNPs were observed in Cs and Cs-OSH solution. The average particle diameter was around 10 nm for Cs/AgNPs sample and close 21 nm for Cs-OSH/AgNPs. Microscopy images showed the deposition of Ag NPs on the surface of cotton fibers. The results indicated that the cotton fibers treated with Cs-OSH/AgNPs solution showed good stability against washing and maintained higher antimicrobial activity even after being exposed to 10 consecutive home laundering conditions. Thus, this work suggests the use of chitosan-organosilicon matrix to improve the bonding between AgNPs and cotton fibers for better and long-term antimicrobial activity.

The motivation of this study was to investigate the feasibility of production of green and sustainable bitumen modified with waste styrofoam (WS) that contributed to the base bitumen in certain rate. To achieve it, not only basic but also rheological properties and storage stability of WS-modified bitumen were taken into consideration. In this respect, bitumen with 70/100 penetration grade was modified with WS in different rates ranging from 1 to 5% with 1% increment. Basic test methods including penetration, softening point, rotational viscometer were conducted on the bitumen samples to analyze physical properties, while dynamic shear rheometer and bending beam rheometer tests were performed on the samples for rheological assessment. Rolling thin film oven and pressure aging vessel tests, which are aging methods in rheological evaluation, were followed to supply short- and long-term aged samples, respectively. Storage stability test was conducted on the modified samples to determine the compatibility between the two materials at different contribution WS rates. The results showed that significant changes occur on both physical and rheological properties of WS-modified bitumen. Compatibility between WS and bitumen was not observed except of the bitumen modified up to 2% WS as examined with softening point, but up to 3% WS as examined with penetration test. Overall, disposal of WS within bitumen modification can be a green and sustainable as considering the ecological and economic aspects.

Particulate matter and airborne microorganisms are two of the most severe indoor air problems due to their significant risks to human health. Comprehensive research on air filtration with good filtration performance for fine particles and antibacterial function is essential. In this study, after some experimentations and optimization of conditions, polyacrylonitrile (PAN) 10-1% silver nanoparticles (AgNPs) membranes with suitable morphology and uniform diameter distribution are fabricated by an electrospinning method. These electrospun mats exhibited antibacterial activity toward (Gram-positive bacteria) and (Gram-negative bacteria). With its small pore size, high porosity, the high specific surface area of 42 m/g, and robust mechanical strength of 7.14 MPa properties, the resultant PAN10%-1%Ag membranes exhibit high filtration efficiency of 99.27%, the low pressure drop of 33 Pa, and higher quality factor compared to the two standard commercial masks including, the three-ply surgical mask and the respirator face mask. After 24 h of the filtration process in a simulated living environment, the obtained air filter still displayed a high filtration efficiency and a less pressure drop variation. In addition, the value was 0.99, which indicates that the calculation results are in good agreement with the measured results. The fabrication of PAN-Ag membranes will have broad applications, including face masks, indoor air filtration and clean room.

In this study, an inorganic-organic composite system was developed through biomineralization of calcium carbonate in the quince-seed mucilage-based hydrogel. Drug-polymer interactions were studied by FTIR, DSC, XRD and SEM analysis. The water absorption capacity was calculated by swelling index. Drug release was determined at various pH. Several in vitro kinetic models were applied to observe drug release behaviour. Studies of drug-polymer interactions and particle flow characteristics of the developed composite material have shown that there is good compatibility between drug and the excipients. The XRD and SEM results confirmed calcite polymorphs in the developed composite material. Thermograms showed that the developed composite material was heat stable. A restricted drug release was observed in an acidic medium (pH 1.2). A controlled drug release was depicted from the developed system at pH 6.8. The drug release mechanism of Super Case II was suggested. The developed system was considered to be an effective drug carrier for colon targeted oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) to avoid gastric irritation and risk of ulceration.

Biopolymers are mainly the polymers which are created or obtained from living creatures such as plants and bacteria rather than petroleum, which has traditionally been the source of polymers. Biopolymers are chain-like molecules composed of repeated chemical blocks derived from renewable resources that may decay in the environment. The usage of biomaterials is becoming more popular as a means of reducing the use of non-renewable resources and reducing environmental pollution produced by synthetic materials. Biopolymers' biodegradability and non-toxic nature help to maintain our environment clean and safe. This study discusses how to improve the mechanical and physical characteristics of biopolymers, particularly in the realm of bioengineering. The paper begins with a fundamental introduction and progresses to a detailed examination of synthesis and a unique investigation of several recent focused biopolymers with mechanical, physical, and biological characterization. Biopolymers' unique non-toxicity, biodegradability, biocompatibility, and eco-friendly features are boosting their applications, especially in bioengineering fields, including agriculture, pharmaceuticals, biomedical, ecological, industrial, aqua treatment, and food packaging, among others, at the end of this paper. The purpose of this paper is to provide an overview of the relevance of biopolymers in smart and novel bioengineering applications.