JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Trending in the right direction: critical access hospitals increased adoption of advanced electronic health record functions from 2018 to 2023
Apathy NC, Holmgren AJ, Nong P, Adler-Milstein J and Everson J
We analyzed trends in adoption of advanced patient engagement and clinical data analytics functionalities among critical access hospitals (CAHs) and non-CAHs to assess how historical gaps have changed.
Linking national primary care electronic health records to individual records from the U.S. Census Bureau's American Community Survey: evaluating the likelihood of linkage based on patient health
Limburg A, Gladish N, Rehkopf DH, Phillips RL and Udalova V
To evaluate the likelihood of linking electronic health records (EHRs) to restricted individual-level American Community Survey (ACS) data based on patient health condition.
Evaluating gradient-based explanation methods for neural network ECG analysis using heatmaps
Storås AM, Mæland S, Isaksen JL, Hicks SA, Thambawita V, Graff C, Hammer HL, Halvorsen P, Riegler MA and Kanters JK
Evaluate popular explanation methods using heatmap visualizations to explain the predictions of deep neural networks for electrocardiogram (ECG) analysis and provide recommendations for selection of explanations methods.
Mini-mental status examination phenotyping for Alzheimer's disease patients using both structured and narrative electronic health record features
Idnay B, Zhang G, Chen F, Ta CN, Schelke MW, Marder K and Weng C
This study aims to automate the prediction of Mini-Mental State Examination (MMSE) scores, a widely adopted standard for cognitive assessment in patients with Alzheimer's disease, using natural language processing (NLP) and machine learning (ML) on structured and unstructured EHR data.
Quantitatively assessing the impact of the quality of SNOMED CT subtype hierarchy on cohort queries
Hao X, Li X, Huang Y, Shi J, Abeysinghe R, Tao C, Roberts K, Zhang GQ and Cui L
SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.
Correction to: Artificial intelligence for optimizing recruitment and retention in clinical trials: a scoping review
Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network
Yu Y, Edelson M, Pham A, Pekar JE, Johnson B, Post K and Kuo TT
Our study aimed to expedite data sharing requests of Limited Data Sets (LDS) through the development of a streamlined platform that allows distributed, immutable management of network activities, provides transparent and intuitive auditing of data access history, and systematically evaluated it on a multi-capacity network setting for meaningful efficiency metrics.
Learning health system linchpins: information exchange and a common data model
Eisman AS, Chen ES, Wu WC, Crowley KM, Aluthge DP, Brown K and Sarkar IN
To demonstrate the potential for a centrally managed health information exchange standardized to a common data model (HIE-CDM) to facilitate semantic data flow needed to support a learning health system (LHS).
Oncointerpreter.ai enables interactive, personalized summarization of cancer diagnostics data
Tripathi A, Ecker B, Boland P, Ghodoussipour S, Riedlinger GR and De S
Cancer diagnosis comes as a shock to many patients, and many of them feel unprepared to handle the complexity of the life-changing event, understand technicalities of the diagnostic reports, and fully engage with the clinical team regarding the personalized clinical decision-making.
Machine learning-based prediction models in medical decision-making in kidney disease: patient, caregiver, and clinician perspectives on trust and appropriate use
Sperling J, Welsh W, Haseley E, Quenstedt S, Muhigaba PB, Brown A, Ephraim P, Shafi T, Waitzkin M, Casarett D and Goldstein BA
This study aims to improve the ethical use of machine learning (ML)-based clinical prediction models (CPMs) in shared decision-making for patients with kidney failure on dialysis. We explore factors that inform acceptability, interpretability, and implementation of ML-based CPMs among multiple constituent groups.
Research for all: building a diverse researcher community for the All of Us Research Program
Baskir R, Lee M, McMaster SJ, Lee J, Blackburne-Proctor F, Azuine R, Mack N, Schully SD, Mendoza M, Sanchez J, Crosby Y, Zumba E, Hahn M, Aspaas N, Elmi A, Alerté S, Stewart E, Wilfong D, Doherty M, Farrell MM, Hébert GB, Hood S, Thomas CM, Murray DD, Lee B, Stark LA, Lewis MA, Uhrig JD, Bartlett LR, Rico EG, Falcón A, Cohn E, Lunn MR, Obedin-Maliver J, Cottler L, Eder M, Randal FT, Karnes J, Lemieux K, Lemieux N, Lemieux N, Bradley L, Tepp R, Wilson M, Rodriguez M, Lunt C and Watson K
The NIH All of Us Research Program (All of Us) is engaging a diverse community of more than 10 000 registered researchers using a robust engagement ecosystem model. We describe strategies used to build an ecosystem that attracts and supports a diverse and inclusive researcher community to use the All of Us dataset and provide metrics on All of Us researcher usage growth.
Efficacy of the mLab App: a randomized clinical trial for increasing HIV testing uptake using mobile technology
Schnall R, Scherr TF, Kuhns LM, Janulis P, Jia H, Wood OR, Almodovar M and Garofalo R
To determine the efficacy of the mLab App, a mobile-delivered HIV prevention intervention to increase HIV self-testing in MSM and TGW.
DySurv: dynamic deep learning model for survival analysis with conditional variational inference
Mesinovic M, Watkinson P and Zhu T
Machine learning applications for longitudinal electronic health records often forecast the risk of events at fixed time points, whereas survival analysis achieves dynamic risk prediction by estimating time-to-event distributions. Here, we propose a novel conditional variational autoencoder-based method, DySurv, which uses a combination of static and longitudinal measurements from electronic health records to estimate the individual risk of death dynamically.
Identifying stigmatizing and positive/preferred language in obstetric clinical notes using natural language processing
Scroggins JK, Hulchafo II, Harkins S, Scharp D, Moen H, Davoudi A, Cato K, Tadiello M, Topaz M and Barcelona V
To identify stigmatizing language in obstetric clinical notes using natural language processing (NLP).
The role of routine and structured social needs data collection in improving care in US hospitals
Richwine C, Patel V, Everson J and Iott B
To understand how health-related social needs (HRSN) data are collected at US hospitals and implications for use.
Comparison of six natural language processing approaches to assessing firearm access in Veterans Health Administration electronic health records
Trujeque J, Dudley RA, Mesfin N, Ingraham NE, Ortiz I, Bangerter A, Chakraborty A, Schutte D, Yeung J, Liu Y, Woodward-Abel A, Bromley E, Zhang R, Brenner LA and Simonetti JA
Access to firearms is associated with increased suicide risk. Our aim was to develop a natural language processing approach to characterizing firearm access in clinical records.
Is ChatGPT worthy enough for provisioning clinical decision support?
Ray PP
Machine learning-based infection diagnostic and prognostic models in post-acute care settings: a systematic review
Xu Z, Scharp D, Hobensek M, Ye J, Zou J, Ding S, Shang J and Topaz M
This study aims to (1) review machine learning (ML)-based models for early infection diagnostic and prognosis prediction in post-acute care (PAC) settings, (2) identify key risk predictors influencing infection-related outcomes, and (3) examine the quality and limitations of these models.
Using human factors methods to mitigate bias in artificial intelligence-based clinical decision support
Militello LG, Diiulio J, Wilson DL, Nguyen KA, Harle CA, Gellad W and Lo-Ciganic WH
To highlight the often overlooked role of user interface (UI) design in mitigating bias in artificial intelligence (AI)-based clinical decision support (CDS).
Real-world federated learning in radiology: hurdles to overcome and benefits to gain
Bujotzek MR, Akünal Ü, Denner S, Neher P, Zenk M, Frodl E, Jaiswal A, Kim M, Krekiehn NR, Nickel M, Ruppel R, Both M, Döllinger F, Opitz M, Persigehl T, Kleesiek J, Penzkofer T, Maier-Hein K, Bucher A and Braren R
Federated Learning (FL) enables collaborative model training while keeping data locally. Currently, most FL studies in radiology are conducted in simulated environments due to numerous hurdles impeding its translation into practice. The few existing real-world FL initiatives rarely communicate specific measures taken to overcome these hurdles. To bridge this significant knowledge gap, we propose a comprehensive guide for real-world FL in radiology. Minding efforts to implement real-world FL, there is a lack of comprehensive assessments comparing FL to less complex alternatives in challenging real-world settings, which we address through extensive benchmarking.
A machine learning framework to adjust for learning effects in medical device safety evaluation
Koola JD, Ramesh K, Mao J, Ahn M, Davis SE, Govindarajulu U, Perkins AM, Westerman D, Ssemaganda H, Speroff T, Ohno-Machado L, Ramsay CR, Sedrakyan A, Resnic FS and Matheny ME
Traditional methods for medical device post-market surveillance often fail to accurately account for operator learning effects, leading to biased assessments of device safety. These methods struggle with non-linearity, complex learning curves, and time-varying covariates, such as physician experience. To address these limitations, we sought to develop a machine learning (ML) framework to detect and adjust for operator learning effects.