JOURNAL OF PEDIATRICS

Liberation from Respiratory Support in Bronchopulmonary Dysplasia
Kielt MJ, Zaniletti I, Lagatta JM, Padula MA, Grover TR, Porta NFM, Wymore EM, Jensen EA, Leeman KT, Levin JC, Evans JR, Yallapragada S, Nelin LD, Vyas-Read S, Murthy K and
To estimate the association between the mode of respiratory support administered at 36 weeks' post-menstrual age (PMA) with time-to-liberation from respiratory support (LRS) in infants with grade 2/3 bronchopulmonary dysplasia (BPD).
National Trends in Breastfeeding by Gestational Age Category
Kalluri NS, Cordova-Ramos EG, Hwang SS, Standish KR and Parker MG
National breastfeeding (direct breastfeeding and/or provision of pumped breast milk) rates among preterm infants are unclear. We report rates of breastfeeding initiation and continuation at 12 weeks after birth by gestational age category from a nationally representative survey between 2009 to 2019. Breastfeeding rates were lowest among infants born late preterm compared with other gestational age categories.
The Pittsburgh Study: A Tiered Model To Support Parents During Early Childhood
Krug CW, Mendelsohn AL, Wuerth J, Roby E and Shaw DS
To test the feasibility of implementing The Pittsburgh Study's (TPS) Early Childhood Collaborative, a population-level, community-partnered initiative to promote relational health by offering accessible preventive parenting program options for families with young children.
Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial
DeMauro SB, Jensen EA, McDonald SA, Hintz S, Tyson J, Stevenson DK, Blakely ML and
The multicenter Necrotizing Enterocolitis Surgery Trial compared initial peritoneal drainage with laparotomy among infants with extremely low birth weight and surgical necrotizing enterocolitis or intestinal perforation. In this post hoc analysis of trial data, initial drainage was associated with adverse respiratory outcomes, both in hospital and through 2 years corrected age.
Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension
Sun H, Stockbridge N, Ivy DD, Clark J, Bates A, Handler SS, Krishnan US, Mullen MP, Yung D, Hopper RK, Varghese NP, Avitabile CM, Fineman J, Austin ED and Freire G
To investigate the feasibility of using actigraphy to measure physical activity (pA) and heart rate variability (HRV) as study endpoints in pediatric pulmonary arterial hypertension (PAH) and to compare their performance to six-minute-walk distance (6MWD), a common primary endpoint used in PAH clinical trials in adults and children who can walk and understand the test process.
Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy
Cornet MC, Gonzalez FF, Glass HC, Wu TW, Wisnowski JL, Li Y, Heagerty P, Juul SE and Wu YW
To determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE).
The Association of the Child Opportunity Index with Emergency Department Presentations for Pediatric Poisonings: A Case-Control Study
Toce MS, Narang C, Monuteaux MC and Bourgeois FT
To examine the relationship between the Child Opportunity Index (COI) and unintentional poisonings in a geographically diverse pediatric population.
Fontan-Associated Liver Disease
Gumm AJ and Rand EB
Longitudinal Analysis of Amplitude-Integrated Electroencephalography for Outcome Prediction in Infants with Hypoxic-Ischemic Encephalopathy: A Validation Study
Rondagh M, de Vries LS, van Steenis A, Meder U, Szakacs L, Jermendy A and Steggerda SJ
To validate the prognostic accuracy of a previously published tool (HOPE calculator) using longitudinal analysis of amplitude-integrated electroencephalography (aEEG) background activity and sleep-wake cycling (SWC) to predict favorable or adverse 2-year neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH), and to evaluate the predictive value for outcome at 5 to 8 years of age.
Markers of Environmental Enteric Dysfunction Are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia
Lauer JM, Pyykkö J, Chembe M, Bilima-Mulenga T, Sikazwe D, Chibwe B, Henderson S, Parkerson D, Leppänen JM, Fink G, Locks LM and Rockers PC
To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.
Early Young Adult Death Underscores the Need for Adolescent and Young Adult Transition Programs in Neurofibromatosis type 1 (NF1)
Tarnawsky T, Oh IY, Hillis E, Gupta A and Gutmann DH
There are few centers with combined pediatric and adult neurofibromatosis 1 practices and transition of care programming. Using an electronic health records-based approach, we found an early death peak in the fourth decade of life largely due to malignancy, underscoring the need for integrated neurological training and practice across the lifespan.
Assessing Early Severity of Hypoxic-Ischemic Encephalopathy: The Role of Electroencephalogram Background in Addition to Sarnat Exam
Cornet MC, Numis AL, Monsell SE, Chan NH, Gonzalez FF, Comstock BA, Juul SE, Wusthoff CJ, Wu YW and Glass HC
To assess the relationship between the Sarnat exam, early electroencephalogram (EEG) background, and death or neurodevelopmental impairment (NDI) at age two years among neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia.
Sleep Disorders Five Years After Acute Provoked Neonatal Seizures
Shellhaas RA, Franck LS, Pilon B, Wusthoff CJ, Massey SL, Chu CJ, Soul JS, Lemmon ME, Numis AL, Sturza JS, Thomas C, Benedetti GM, Rau S, Anwar T, Berl MM, McCulloch CE and Glass HC
To evaluate whether abnormal sleep is associated with adverse outcomes for children who survived acute provoked neonatal seizures, and their parents' well-being.
Congenital Goiter due to Inborn Error in Synthesis with Treatment Response
Patel A and Krishnasarma R
Characteristics of Fentanyl Toxicity in Very Young Children
Temple C, Cassidy E and Hendrickson RG
Children exposed to illicit fentanyl often experience severe toxicity, receive repeated naloxone doses and prolonged airway support. This retrospective study presents the clinical course and management of four cases, emphasizing the urgent need for prompt recognition and intervention to address the severe, extended effects of illicit fentanyl exposure in very young children.
Cardiopulmonary Physiology of Hypoxemic Respiratory Failure among Preterm Infants with Septic Shock
Kharrat A, Nissimov S, Zhu F, Deshpande P and Jain A
To examine cardiopulmonary physiological alterations associated with hypoxemic respiratory failure (HRF; fraction of inspired oxygen ≥0.60) among preterm neonates requiring vasopressors/inotropes during sepsis (septic shock).
Noninvasive Respiratory Support for Stabilization after Birth is A Safe Approach in Micropreterm Infants
Mehrem AA and Beltempo M
Impact of Rural School-Based Health Centers on Asthma Management
Brunner WM, Han Z, Tennyson S, Fiduccia PC, Krupa N and Kjolhede C
To test the hypothesis that students with asthma who have access to school-based health centers (SBHCs) receive more recommended preventive care and use less emergency care, we compared patterns of health care utilization among rural students with asthma by SBHC access.
Reconsidering Initial Respiratory Support Strategies in Infants Born Preterm
Wu Y and Xu W
The Role of Body Mass Index on Physical Activity, Symptoms, and Related Outcomes Following Pediatric Concussion
Eagle SR, Zynda AJ, Sandulli L, Hickey RW, Kegel NE, Nelson L, McCrea M, Collins MW, Okonkwo DO, Thomas DG and Kontos AP
To determine the step count and self-reported activity levels for obese and non-obese pediatric patients following concussion and predict self-reported symptoms, quality of life, and psychological health over time.
Trajectory of Postnatal Oxygen Requirement in Extremely Preterm Infants
Groves AM, Bennett MM, Loyd J, Clark RH and Tolia VN
To describe the trends in percentage oxygen requirement and mode of respiratory support delivered to extremely premature infants in the 12 weeks after birth.