Although diverse language deficits have been widely observed in prodromal Alzheimer's disease (AD), the underlying nature of such deficits and their explanation remains opaque. Consequently, both clinical applications and brain-language models are not well-defined. In this paper we report results from two experiments which test language production in a group of individuals with amnestic Mild Cognitive Impairment (aMCI) in contrast to healthy aging and healthy young. The experiments apply factorial designs informed by linguistic analysis to test two forms of complex sentences involving anaphora (relations between pronouns and their antecedents). Results show that aMCI individuals differentiate forms of anaphora depending on sentence structure, with selective impairment of sentences which involve construal with reference to context (anaphoric coreference). We argue that aMCI individuals maintain core structural knowledge while evidencing deficiency in syntax-semantics integration, thus locating the source of the deficit in the language-thought interface of the Language Faculty.

Speech perception skills have been implicated in the development of phoneme-grapheme correspondence, yet the exact nature of speech perception and word reading ability remains unknown. We investigate phonological sensitivity to native (English) and nonnative (Spanish) speech syllables within an auditory oddball paradigm using event related potentials (ERPs) collected from lateral temporal electrode sites in 33 monolingual English-speaking children aged 6-8 years (N=33). We further explore the relationship between ERPs to English word reading abilities for this group. Results revealed that language stimuli (English, Spanish), ERP condition (standard, deviant), and hemisphere (left, right) all influenced the lateral N1 component. ERPs recorded from deviant English stimuli were significantly more negative within the left hemisphere compared to all other recorded ERPs. Mean amplitude differences within the N1 in left lateral electrode sites recorded in response to English phoneme contrasts significantly predicted English word reading abilities within this sample. Results indicate that speech perception of native contrasts recorded in left temporal electrode sites for the N1 component are linked to English word reading abilities in early school-aged children.

Adjectives (e.g., ) are an important part of language, but have been little studied in individuals with impaired language. Adjectives are used in two different ways in English: , to modify a noun (); or , after a verb (). Attributive adjectives have a more complex grammatical structure than predicative adjectives, and may therefore be particularly prone to disruption in individuals with grammatical impairments. We investigated adjective production in three subtypes of primary progressive aphasia (PPA: agrammatic, semantic, logopenic), as well as in agrammatic stroke aphasia and a group of healthy control participants. Participants produced narratives based on picture books, and we coded every adjective they produced for its syntactic structure. Compared to healthy controls, the two agrammatic groups, but not the other two patient groups, produced significantly fewer attributive adjectives per sentence. All four patient groups were similar to controls for their rate of predicative adjective production. In addition, we found a significant correlation in the agrammatic PPA participants between their rate of producing attributive adjective and impaired production of sentences with complex syntactic structure (subject cleft sentences like ); no such correlation was found for predicative adjectives. Irrespective of structure, we examined the lexical characteristics of the adjectives that were produced, including length, frequency, semantic diversity and neighborhood density. Overall, the lexical characteristics of the produced adjectives were largely consistent with the language profile of each group. In sum, the results suggest that attributive adjectives present a particular challenge for individuals with agrammatic language production, and add a new dimension to the description of agrammatism. Our results further suggest that attributive adjectives may be a fruitful target for improved treatment and recovery of agrammatic language.

Although researchers often rely on group-level fMRI results to draw conclusions about the neurobiology of language, doing so without accounting for the complexities of individual brains may reduce the validity of our findings. Furthermore, understanding brain organization in individuals is critically important for both basic science and clinical translation. To assess the state of single-subject language localization in the functional neuroimaging literature, we carried out a systematic review of studies published through April 2020. Out of 977 papers identified through our search, 121 met our inclusion criteria for reporting single-subject fMRI results (fMRI studies of language in adults that report task-based single-subject statistics). Of these, 20 papers reported using a single-subject test-retest analysis to assess reliability. Thus, we found that a relatively modest number of papers reporting single-subject results quantified single-subject reliability. These varied substantially in acquisition parameters, task design, and reliability measures, creating significant challenges for making comparisons across studies. Future endeavors to optimize the localization of language networks in individuals will benefit from the standardization and broader reporting of reliability metrics for different tasks and acquisition parameters.

We examined the auditory sentence processing of neurologically unimpaired listeners and individuals with aphasia on canonical sentence structures in real-time using a visual-world eye-tracking paradigm. The canonical sentence constructions contained multiple noun phrases and an unaccusative verb, the latter of which formed a long-distance dependency link between the unaccusative verb and its single argument (which was base generated in the object position and then displaced to the subject position). To explore the likelihood of similarity-based interference during the real time linking of the verb and the sentence's subject noun, we manipulated the animacy feature of the noun phrases (matched or mismatched). The study's objectives were to examine whether (a) reducing the similarity-based interference by mismatching animacy features would modulate the encoding and retrieval dynamics of noun phrases in real-time; and (b) whether individuals with aphasia would demonstrate on time sensitivity to this lexical-semantic cue. Results revealed a significant effect of this manipulation in individuals both with and without aphasia. In other words, the mismatch in the representational features of the noun phrases increased the distinctiveness of the unaccusative verb's subject target at the time of syntactic retrieval (verb offset) for individuals in both groups. Moreover, individuals with aphasia were shown to be sensitive to the lexical-semantic cue, even though they appeared to process it slower than unimpaired listeners. This study extends to the cue-based retrieval model by providing new insight on the real-time mechanisms underpinning sentence comprehension.

Processing deficits at the lexical level, such as delayed and reduced lexical activation, have been theorized as the source of breakdowns in syntactic operations and thus contribute to sentence comprehension deficits in individuals with aphasia (IWA). In the current study, we investigate the relationship between lexical and syntactic processing in object-relative sentences using eye-tracking while listening in IWA. We explore whether manipulating the time available to process a critical lexical item (the direct-object noun) when it is initially heard in a sentence has an immediate effect on lexical access as well as a downstream effect on syntactic processing. To achieve this aim, we use novel temporal manipulations to provide additional time for lexical processing to occur. In addition to exploring these temporal effects in IWA, we also seek to understand the effect that additional time has on sentence processing in neurotypical age-matched adults (AMC). We predict that the temporal manipulations designed to provide increased processing time for critical lexical items will 1) enhance lexical processing of the target noun, 2) facilitate syntactic integration, and 3) improve sentence comprehension for both IWA and AMC. We demonstrate that strengthening lexical processing via the addition of time can affect lexical processing and facilitate syntactic retrieval of the target noun and lead to enhanced interference resolution in both unimpaired and impaired systems. In aphasia, additional time can mitigate impairments in spreading activation thereby improving lexical access and reducing interference during downstream dependency linking. However, individuals with aphasia may require longer additions of time to fully realize these benefits.

Language and music rely on complex sequences organized according to syntactic principles that are implicitly understood by enculturated listeners. Across both domains, syntactic processing involves predicting and integrating incoming elements into higher-order structures. According to the Shared Syntactic Integration Resource Hypothesis (SSIRH; Patel, 2003), musical and linguistic syntactic processing rely on shared resources for integrating incoming elements (e.g., chords, words) into unfolding sequences. One prediction of the SSIRH is that people with agrammatic aphasia (whose deficits are due to syntactic integration problems) should present with deficits in processing musical syntax. We report the first neural study to test this prediction: event-related potentials (ERPs) were measured in response to musical and linguistic syntactic violations in a group of people with agrammatic aphasia (n=7) compared to a group of healthy controls (n=14) using an acceptability judgement task. The groups were matched with respect to age, education, and extent of musical training. Violations were based on morpho-syntactic relations in sentences and harmonic relations in chord sequences. Both groups presented with a significant P600 response to syntactic violations across both domains. The aphasic participants presented with a reduced-amplitude posterior P600 compared to the healthy adults in response to linguistic, but not musical, violations. Participants with aphasia did however present with larger frontal positivities in response to violations in both domains. Intriguingly, extent of musical training was associated with larger posterior P600 responses to syntactic violations of language and music in both groups. Overall, these findings are not consistent with the predictions of the SSIRH, and instead suggest that linguistic, but not musical, syntactic processing may be selectively impaired in stroke-induced agrammatic aphasia. However, the findings also suggest a relationship between musical training and linguistic syntactic processing, which may have clinical implications for people with aphasia, and motivates more research on the relationship between these two domains.

Many language functions are traditionally assigned to cortical brain areas, leaving the contributions of subcortical structures to language processing largely unspecified. The present study examines a potential role of the subthalamic nucleus (STN) in lexical processing, specifically, reading aloud of words (e.g., 'fate') and pseudowords (e.g., 'fape'). We recorded local field potentials simultaneously from the STN and the cortex (precentral, postcentral, and superior temporal gyri) of 13 people with Parkinson's disease undergoing awake deep brain stimulation and compared STN's lexicality-related neural activity with that of the cortex. Both STN and cortical activity demonstrated significant task-related modulations, but the lexicality effects were different in the two brain structures. In the STN, an increase in gamma band activity (31-70 Hz) was present in pseudoword trials compared to word trials during subjects' spoken response. In the cortex, a greater decrease in beta band activity (12-30 Hz) was observed for pseudowords in the precentral gyrus. Additionally, 11 individual cortical sites showed lexicality effects with varying temporal and topographic characteristics in the alpha and beta frequency bands. These findings suggest that the STN and the sampled cortical regions are involved differently in the processing of lexical distinctions.

Recent studies have demonstrated variation in language processing for monolingual and bilingual speakers alike, suggesting that only by considering individual differences will an accurate picture of the consequences of language experience be adequately understood. This approach can be illustrated in ERP research that has shown that sentence contexts that traditionally elicit a P600 component in response to a syntactic violation, elicit an N400 response for a subset of individuals. That result has been reported for monolingual speakers processing sentences in their L1 and also for bilinguals processing sentences in their L2. To date, no studies have compared variation in L1 and L2 ERP effects in the very same bilingual speakers. In the present paper, we do that by examining sentence processing in heritage bilinguals who acquired both languages from early childhood but for whom the L2 typically becomes the dominant language. Variation in ERPs produced by the non-dominant L1 and dominant L2 of heritage bilinguals was compared to variation found in monolingual L1 processing. The group-averaged results showed the smallest N400 and P600 responses in the native, but no longer dominant, L1 of heritage bilinguals, and largest in the monolinguals. Individual difference analyses linking ERP variation to working memory and language proficiency showed that working memory was the primary factor related to monolingual L1 processing, whereas bilinguals did not show this relationship. In contrast, proficiency was the primary factor related to ERP responses for no longer dominant L1 for bilinguals, but unrelated to monolingual L1 processing, whereas bilinguals' dominant L2 processing showed an intermediate relationship. Finally, the N400 was absent for bilinguals performing the task in the same language in which they initially learned to read, but significantly larger when bilinguals performed the task in the other language. The results support the idea that proficient bilinguals utilize the same underlying mechanisms to process both languages, although the factors that affect processing in each language may differ. More broadly, we find that bilingualism is an experience that opens the language system to perform fluidly under changing circumstances, such as increasing proficiency. In contrast, language processing in monolinguals was primarily related to relatively stable factors (working memory).

In this study we examined the neural control mechanisms that are at play when habitual code-switchers read code-switches embedded in a sentence context. The goal was also to understand if and to what extent the putative control network that is engaged during the comprehension of code-switched sentences is modulated by the linguistic regularity of those switches. Towards that goal, we tested two different types of code switches (switches at the noun-phrase boundary and switches at the verb-phrase boundary) that despite being both represented in naturalistic corpora of code switching, show different distributional properties. Results show that areas involved in general cognitive control (e.g., pre-SMA, anterior cingulate cortex) are recruited when processing code-switched sentences, relative to non-code-switched sentences. Additionally, significant activation in the cerebellum when processing sentences containing code-switches at the noun-phrase boundary suggests that habitual code-switchers might engage a wider control network to adapt inhibitory control processes according to task demands. Results are discussed in the context of the current literature on neural models of bilingual language control.

The present study examined how healthy aging and aphasia influence the capacity for readers to generate structural predictions during online reading, and how animacy cues influence this process. Non-brain-damaged younger (n =24) and older (n =12) adults (Experiment 1) and individuals with aphasia (IWA; n =11; Experiment 2) read subject relative and object relative sentences in an eye-tracking experiment. Half of the sentences included animate sentential subjects, and the other half included inanimate sentential subjects. All three groups used animacy information to mitigate effects of syntactic complexity. These effects were greater in older than younger adults. IWA were sensitive to structural frequency, with longer reading times for object relative than subject relative sentences. As in previous work, effects of structural complexity did not emerge on IWA's first pass through the sentence, but were observed when IWA reread critical segments of the sentences. Thus, IWA may adopt atypical reading strategies when they encounter low frequency or complex sentence structures, but they are able to use animacy information to reduce the processing disruptions associated with these structures.

Recent work within the language sciences, particularly bilingualism, has sought new methods to evaluate and characterize how people differentially use language across different communicative contexts. These differences have thus far been linked to changes in cognitive control strategy, reading behavior, and brain organization. Here, we approach this issue using a novel application of Network Science to map the conversational topics that Montréal bilinguals discuss across communicative contexts (e.g., work, home, family, school, social), in their dominant vs. non-dominant language. Our results demonstrate that all communicative contexts display a unique pattern in which conversational topics are discussed, but only a few communicative contexts (work and social) display a unique pattern of how many languages are used to discuss particular topics. We also demonstrate that the dominant language has greater network size, strength, and density than the non-dominant language, suggesting that more topics are used in a wider variety of contexts in this language. Lastly, using community detection to thematically group the topics in each language, we find evidence of greater specificity in the non-dominant language than the dominant language. We contend that Network Science is a valuable tool for representing complex information, such as individual differences in bilingual language use, in a rich and granular manner, that may be used to better understand brain and behavior.

A recent approach to explaining the domain-general cognitive outcomes of bilingualism is to consider the role of disengagement of attention, rather than the engagement of focused attention or inhibition as typical in most accounts. The present study pursues this approach by examining the neurophysiological changes associated with disengagement of attention in young adults performing an inhibition of return (IOR) paradigm while EEG was recorded. Participants were drawn from a diverse community and varied widely in their bilingual experience. There were three main findings. First, dividing the sample into dichotomous groups based on language proficiency did not lead to reliable group differences on the task. Second, using instead continuous measures of bilingualism across the sample indicated that greater bilingual experience and proficiency were associated with the magnitude of the IOR effect, with more bilingual individuals showing larger and earlier IOR effects. Finally, a network of processes that are temporally and spatially distinct were found to work together to produce facilitation, disengagement of attention, and inhibition of return. These findings contribute to debates regarding the electrophysiological correlates of the IOR effect and provide additional evidence for how bilingualism affects domain-general cognition.

Language can influence cognition in domains as varied as temporal processing, spatial categorization, and color perception (Casasanto & Boroditsky, 2008; Levinson & Wilkins, 2006; Winawer et al., 2007). Here, we provide converging behavioral and neural evidence that bilingual experience can change semantic associations. In Experiment 1, Spanish- and English-speaking bilinguals rated semantically unrelated picture pairs (e.g., ) as significantly more related in meaning than English monolinguals. Experiment 2 demonstrated that bilinguals who were highly proficient in Spanish and English rated both semantically related (e.g., ) and unrelated picture pairs (e.g., ) as more related than monolinguals and low-proficiency bilinguals. Experiment 3 added ERP measures to provide a more sensitive test of the bilingual effect on semantic ratings, which was assessed through the use of linguistic stimuli (related and unrelated words instead of pictures) and a different bilingual population (Korean-English bilinguals). Bilingualism was associated with a significantly smaller N400 effect (i.e., N400 for unrelated - related), suggesting that bilinguals processed related and unrelated pairs more similarly than monolinguals; this result was coupled with a non-significant behavioral trend of bilinguals judging unrelated words as more related than monolinguals did. Across the three experiments, results show that bilingual experience can influence perceived semantic associations. We propose that bilinguals' denser and more interconnected phonological, orthographic and lexical systems may change the links between semantic concepts. Such an account is consistent with connectionist models of language that allow for phonological and lexical influences on conceptual representations, with implications for models of bilingual language processing.

The meanings of most open class words are suffused with sensory and affective features. A word such as , for example, evokes polymodal associations ranging from gritty sand (tactile) and crashing waves (auditory) to the distinctive smell of sunscreen (olfactory). Aristotle argued for a hierarchy of the senses where vision and audition eclipse the lesser modalities of odor, taste, and touch. A direct test of Aristotle's premise was recently made possible with the establishment of the Lancaster Sensorimotor Norms (2019), a crowdsourced database cataloging sensorimotor salience for nearly 40,000 English words. Neurosynth, a metanalytic database of functional magnetic resonance imaging studies, can potentially confirm if Aristotle's sensory hierarchy is reflected in functional activation within the human brain. We correlated sensory salience of English words as assessed by subjective ratings of vision, audition, olfaction, touch, and gustation (Lancaster Ratings) with volumes of cortical activation for each of these respective sensory modalities (Neurosynth). English word ratings reflected the following sensory hierarchy: vision > audition > haptic > olfaction ≈ gustation. This linguistic hierarchy nearly perfectly correlated with voxel counts of functional activation maps by each sensory modality (Pearson r=.99). These findings are grossly consistent with Aristotle's hierarchy of the senses. We discuss implications and counterevidence from other natural languages.

Bilinguals are remarkable at -switching between languages only when they want. However, language control in production can involve . That is, switching to another language takes longer than staying in the same language. Moreover, bilinguals sometimes produce , mistakenly producing words in an unintended language (e.g., Spanish-English bilinguals saying "pero" instead of "but"). Switch costs are also found in comprehension. For example, reading times are longer when bilinguals read sentences with language switches compared to sentences with no language switches. Given that both production and comprehension involve switch costs, some language-control mechanisms might be shared across modalities. To test this, we compared language switch costs found in eye-movement measures during silent sentence reading (comprehension) and intrusion errors produced when reading aloud switched words in mixed-language paragraphs (production). Bilinguals who made more intrusion errors during the read-aloud task did not show different switch cost patterns in most measures in the silent-reading task, except on skipping rates. We suggest that language switching is mostly controlled by separate, modality-specific processes in production and comprehension, although some points of overlap might indicate the role of domain general control and how it can influence individual differences in bilingual language control.

Parkinson's disease (PD), which involves the degeneration of dopaminergic neurons in the basal ganglia, has long been associated with motor deficits. Increasing evidence suggests that language can also be impaired, including aspects of syntactic and lexical processing. However, the exact pattern of these impairments remains somewhat unclear, for several reasons. Few studies have examined and compared syntactic and lexical processing within subjects, so their relative deficits remain to be elucidated. Studies have focused on earlier stages of PD, so syntactic and lexical processing in later stages are less well understood. Research has largely probed English and a handful of other European languages, and it is unclear whether findings generalize more broadly. Finally, few studies have examined links between syntactic/lexical impairments and their neurocognitive substrates, such as measures of basal ganglia degeneration or dopaminergic processes. We addressed these gaps by investigating multiple aspects of Farsi syntactic and lexical processing in 40 Farsi native-speaking moderate-to-severe non-demented PD patients, and 40 healthy controls. Analyses revealed equivalent impairments of syntactic comprehension and syntactic judgment, across different syntactic structures. Lexical processing was impaired only for motor function-related objects (e.g., naming 'hammer', but not 'mountain'), in line with findings of PD deficits at naming action verbs as compared to objects, without the verb/noun confound. In direct comparisons between lexical and syntactic tasks, patients were better at naming words like 'mountain' (but not words like 'hammer') than at syntactic comprehension and syntactic judgment. Performance at syntactic comprehension correlated with the last levodopa equivalent dose. No other correlations were found between syntactic/lexical processing measures and either levodopa equivalent dose or hypokinesia, which reflects degeneration of basal ganglia motor-related circuits. All critical significant main effects, interactions, and correlations yielded large effect sizes. The findings elucidate the nature of syntactic and lexical processing impairments in PD.

Recent evidence has shown that convergence of print and speech processing across a network of primarily left-hemisphere regions of the brain is a predictor of future reading skills in children, and a marker of fluent reading ability in adults. The present study extends these findings into the domain of second-language (L2) literacy, through brain imaging data of English and Hebrew L2 learners. Participants received an fMRI brain scan, while performing a semantic judgement task on spoken and written words and pseudowords in both their L1 and L2, alongside a battery of L1 and L2 behavioural measures. Imaging results show, overall, show a similar network of activation for reading across the two languages, alongside significant convergence of print and speech processing across a network of left-hemisphere regions in both L1 and L2 and in both cohorts. Importantly, convergence is greater for L1 in occipito-temporal regions tied to automatic skilled reading processes including the visual word-form area, but greater for L2 in frontal regions of the reading network, tied to more effortful, active processing. The main groupwise brain effects tell a similar story, with greater L2 than L1 activation across frontal, temporal and parietal regions, but greater L1 than L2 activation in parieto-occipital regions tied to automatic mapping processes in skilled reading. These results provide evidence for the shifting of the reading networks towards more automatic processing as reading proficiency rises and the mappings and statistics of the new orthography are learned and incorporated into the reading system.

There has been virtual explosion of studies published in cognitive neuroscience primarily due to increased accessibility to neuroimaging methods, which has led to different approaches in interpretation. This review seeks to synthesize both developmental approaches and more recent views that consider neuroimaging. The ways in which Neuronal Recycling, Neural Reuse, and Language as Shaped by the Brain perspectives seek to clarify the brain bases of cognition will be addressed. Neuroconstructivism as an additional explanatory framework which seeks to bind brain and cognition to development will also be presented. Despite sharing similar goals, the four approaches to understanding how the brain is related to cognition have generally been considered separately. However, we propose that all four perspectives argue for a form of Emergentism in which combinations of smaller elements can lead to a greater whole. This discussion seeks to provide a synthesis of these approaches that leads to the emergence of a theory itself. We term this new synthesis Neurocomputational Emergentism (or Neuromergentism for short).

In response to Hernandez and colleagues (2018), we provide commentary on the scientific reasoning that underlies Neuroemergentism. We argue that bilingual language and reading acquisition provide a means for examining and refining the neuroemergentist framework.

A comorbidity of attention deficit hyperactivity disorder (ADHD) with reading difficulties (RD) is common in children. However, children with ADHD+RD have a different reading and executive functions (EF) profile than children with RD alone. We compared the effect of an EF-based intervention on neural circuits related to EF in children with RD and those with ADHD+RD. Functional connectivity MRI data from a lexical decision task suggest that the RD-alone group showed greater improvement in EF and reading tests and greater functional connectivity between networks related to both higher-and lower-level visual processing and those related to ventral attention and dorsal attention, as well as semantic processing. Children with ADHD+RD showed greater connectivity between networks related to attention and dorsal attention and those related to visual processing and EF. Results are consistent with the Cognitive Subtype hypothesis and suggest that RD and ADHD+RD, although related behaviourally, are distinct disorders with regard to network response and connectivity during reading and after an EF-based intervention.

Some current models of aphasia emphasize a role of short-term memory in the processing of language and propose that the language impairment in aphasia involves impairment to cognitive processes that activate and maintain representations of words over the time-period needed to support single word and multiple word tasks, including verbal span tasks. This paper reports normative data from 39 people with aphasia and 16 age-matched neurotypical controls on a test battery for aphasia that assesses effects of increased short-term/working memory load on word and sentence processing as well as effects of linguistic variations on verbal short-term memory abilities Two concepts are discussed that capture the unique potential of this test battery for research and clinical practice: specificity of diagnosis and sensitivity to all degrees of aphasia severity, including mild aphasia. An analysis is included that shows how the performance of individuals with mild aphasia who achieve normal level of performance on the Western Aphasia Battery (Kertesz, 2006) show a decline in a temporal delay condition that is greater than performance of control participants. We also report preliminary data showing differential effects of adding a time interval before a response or between items to be compared: reduced accuracy for some individuals with aphasia and improved accuracy for others. The theoretical and clinical importance of this finding is discussed, as well as the overall potential for this test battery to be used in research and as a clinical tool. Finally, we discuss the relevance of this test battery to investigate functional communication abilities in aphasia.

Auditory-verbal short-term memory impairments are part and parcel of aphasia and interfere with linguistic processing. To date, the science about short-term memory impairments in aphasia has been generated and dominated by studying measures of accuracy, that is, span length. Because accuracy is expressed through speech, examining the speech-timing characteristics of persons with aphasia as they engage in spoken recall could reveal insights about the manner in which accuracy is achieved. Six speech-timing measures (e.g., response durations, pause durations) were elicited from the speech waveform of word span tasks from twelve people with aphasia. Speech-timing measures were compared to neuro-typical control participants. Speech-timing performance between erroneous and correct responses in the aphasia group was also examined. Across all measures, people with aphasia produced considerably longer speech-timing patterns in comparison to control participants. Memory load affected some measures in people with aphasia and control participants. Speech-timing in correct response trials was shorter than responses in erroneous trials. Memory span correlated only with one measure, namely, speech time (defined as the sum of each individual word duration in a response). Speech time also correlated with the following measures: Aphasia severity (Aphasia Quotient of the Western Aphasia Battery), spontaneous speech, and language comprehension (also measured by the Western Aphasia Battery). Some protracted speech-timing patterns in the aphasia group may be explained by a deregulation of activation-decay patterns. However, in the absence of further evidence from people with aphasia, possible issues around the sensitivity of some speech-timing measures limit firmer conclusions. Speech-timing measures are response-time measures, which have not been systematically studied in studies of short-term or working memory in aphasia and as such, can push the current boundaries of knowledge of short-term and working memory impairments in aphasia, not only in stroke related aphasia but also other neurological conditions.

The purpose of this study was to characterize further the nature of sentence processing deficits in acquired aphasia. Adults with aphasia and age-and education-matched adults with no brain damage completed a battery of formal cognitive-linguistic tests and an experimental sentence judgment task, which was performed alone and during focused attention and divided attention or dual-task conditions. The specific aims were to determine whether (a) increased extra-linguistic cognitive demands (i.e., focused and divided conditions) differentially affected the sentence judgement performances of the aphasic and control groups, (b) increased extra- linguistic cognitive demands interact with stimulus parameters (i.e., syntactic complexity, number of propositions) known to influence sentence processing, and (c) syntactic- or material specific resource limitations (e.g., sentence judgment in isolation), general cognitive abilities (e.g., short-term and working memory test scores), or both share a significant relationship with dual-task outcomes. Accuracy, grammatical sensitivity, and reaction time findings were consistent with resource models of aphasia and processing accounts of aphasic syntactic limitations, underscoring the theoretical and clinical importance of acknowledging and specifying the strength and nature of interactions between linguistic and extra-linguistic cognitive processes in not only individuals with aphasia, but also other patient and typical aging populations.

Visuospatial processing deficits are typically associated with damage to the right hemisphere. However, deficits on spatial working memory have been reported among some individuals with focal left hemisphere damage (LHD). It has been suggested that the left hemisphere may play a role in such non-verbal working memory tasks due to the use of subvocal, verbally-mediated strategies. The current study investigated the role of the left hemisphere in spatial working memory by testing spatial span performance, both forward and backward, in a large group of individuals with a history of left hemisphere stroke. Our first aim was to establish whether individuals with LHD are indeed impaired on spatial span tasks using standardized span tasks with published normative data. Our second aim was to identify the role that language plays in supporting spatial working memory by comparing LHD individuals with and without aphasia, and by relating spatial span performance to performance on a series of language measures. Our third aim was to identify left hemisphere brain regions that contribute to spatial working memory using voxel-based lesion symptom mapping (VLSM), a whole-brain statistical approach that identifies regions critical to a particular behavior on a voxel-by-voxel basis. We found that 28% of individuals with LHD performed in the clinically-impaired range on forward spatial span and 16% performed in the clinically-impaired range on backward spatial span. There were no significant differences in performance between individuals with and without aphasia, and there were no correlations between spatial span performance and language functions such as repetition and comprehension. The VLSM analysis showed that backward spatial span was associated with a left fronto-parietal network consisting of somatosensory cortex, the supramarginal gyrus, lateral prefrontal cortex, and the frontal eye fields. Regions identified in the VLSM analysis of forward spatial span did not reach the conservative statistical threshold for significance. Overall, these results suggest that spatial working memory, as measured by spatial span, can be significantly disrupted in a subset of individuals with LHD whose lesions infringe on a network of regions in the left hemisphere that have been implicated in domain-general working memory and attentional control mechanisms.

We investigate three potential mechanisms underlying the deficit in idiom comprehension seen in aphasia: difficulty inhibiting literal meanings, inability to recognize that a figurative interpretation is required, and difficulty processing abstract words and concepts. Unimpaired adults and PWA read high and moderate familiarity idioms either preceded or followed by a figuratively biasing context sentence. They then completed a string-to-word probe selection task, choosing between a figurative target, a literal lure, and unrelated concrete and abstract lures. PWA chose the figurative target more often for more familiar idioms and after figuratively biasing contexts, suggesting that difficulty accessing figurative meanings may be a key contributor to idiom impairment in aphasia. Importantly, PWA chose abstract lures at the same rate as they chose literal lures, suggesting that abstract lures may be considered equally good matches for weak idiomatic representations in PWA, and therefore that idiomatic figurative meanings may be represented similarly to abstract concepts for PWA. These results have implications for models of idiom comprehension in aphasia, as well as the design of future studies of idiom comprehension in PWA.

Genetic variants related to dopamine functioning (e.g., the ANKK1/TaqIa polymorphism within the gene and the Val158Met polymorphism within the gene) have previously been shown to predict cognitive flexibility and learning (e.g., Colzato et al., 2010; Stelzel et al., 2010). Additionally, researchers have found that these genetic variants may also predict second language learning (Mamiya et al., 2016), although this relationship may change across the lifespan (Sugiura et al., 2011). The current study examined the role of the ANKK1/TaqIa and Val158Met polymorphisms along with age of second language acquisition (AoA) in order to predict levels of bilingual proficiency in Spanish-English bilinguals. Results indicated a three-way interaction such that the relationship between the genetic variants and bilingual proficiency depended on AoA. At earlier AoAs, having the genetic variant associated with higher levels of subcortical dopamine (A1+) predicted the highest levels of bilingual proficiency. At later AoAs, individuals with the genetic variant associated with cortical dopamine levels that are balanced between stability and flexibility (Val/Met) predicted the highest levels of bilingual proficiency. These results fit with theories about the development of language as a subcortical process early in life and as a cortical process later in life (Hernandez & Li, 2007), as well as the importance of both stability and flexibility in bilingual language development (Green & Abutalebi, 2013). Finally, this study raises questions about the direction of causality between bilingualism and cognitive control, which is central to the debate over the "bilingual advantage."