Medical students around the world have been found to have high rates of depression and anxiety as compared to the general population. This study aimed to assess these in medical students immediately after they joined medical school and six months later. This study also aimed to assess if there was any association with stress, anxiety, and depression scores at six months follow-up with coping styles, self-esteem, personality, family functioning, and academic performance.

Randomized controlled trials (RCTs) are a gold standard in evidence-based research. However, RCTs have limitations, among which the most commonly acknowledged is that narrow study selection criteria compromise the external validity of the findings. This article briefly touches upon this and other well-recognized limitations and presents, in greater detail, less commonly acknowledged limitations with examples from contemporary literature. Important among the less commonly acknowledged limitations are biases in RCTs of interventions to which patients cannot be blinded, weaknesses in the design of maintenance therapy RCTs, and, ubiquitously, post-randomization biases. The listed limitations notwithstanding, RCTs are still the best among research designs. What is important is to recognize the imperfections in each RCT so that the findings of the RCT can be better judged.

Relapse and treatment dropout are key challenges in opioid use disorder that need effective intervention strategies. Motivation enhancement therapy may be effective in improving opioid use disorder treatment outcomes.

The current study aimed to develop and implement the National Assistance in Mental Health for Health Care Providers (NAMAH) module, which focused on wellness and building resilience for a cohort of physicians.

The revision and updating of questionnaires are part of the list of comprehensive guidelines for using psychological questionnaires. The present study aimed to test the construct and convergent validity of the Persian versions of six personality questionnaires including the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A: 35 items), the Affective and Emotional Composite Temperament Scale (AFECTS: 48 items), the Temperament and Character Inventory (TCI: 125 items), the Positive Affect and Negative Affect Schedule (PANAS: 20 items), the NEO-Five-Factor Inventory (NEO-FFI: 60 items), and Personality Diagnostic Questionnaire-4 (PDQ-4: 99 items).

Looking at the alarming increase in the incidence of attempted suicide worldwide, having adequate expertise in managing people with attempted suicide is imperative. Therefore, healthcare professionals, specifically nurses, must be provided training exclusively on managing patients with attempted suicide and preventing suicide in the near and distant future. Nursing staff play a major role as a point of first contact for suicide survivors, and therefore, it is of utmost importance that they are adequately trained and knowledgeable in this area. To understand their knowledge, the authors decided to do this study to measure knowledge, attitude, and practice (KAP) among nurses in suicide survivors.

The conventional and standard pharmacological approaches in the management of bipolar disorders include mood stabilizers and second-generation antipsychotics. However, renal problems owing to the gold standard mood stabilizer, lithium, is three times that of the general population. As bipolar I disorder (BPD I) is associated with overactive protein kinase C (PKC) intracellular signaling, a novel approach in the management of acute mania/mixed affective states of bipolar disorder includes the use of PKC inhibitors, such as Tamoxifen and its derivative metabolite molecule, Endoxifen. Our objective is to report two cases of bipolar disorder that presented in acute manic episodes, with preexisting renal disease, and safe use of Endoxifen as an adjunct/monotherapy for rapid control of symptoms. According to our study, Endoxifen can be used as an anti-manic agent, either as monotherapy or as an adjunct, in patients with renal disease. It can also be used as an effective cover therapy for bipolar disorder patients requiring steroids for the treatment of renal pathology, though long-term studies are needed to assess the long-term safety and efficacy.

Caregivers play an important role in children's development. Therefore, they need to recognize the learning difficulties that their children face and support them to ensure learning gains and prevent secondary complications. Nevertheless, supporting a child with a learning disability can be challenging for caregivers in many ways. This study investigated caregivers' knowledge of dyslexia, their challenges when raising children with dyslexia, and the support they seek to raise such children.

Inflammatory cytokines are associated with the pathophysiology of major depressive disorder (MDD). Nevertheless, whether they are trait or state biomarkers remains unclear. We aimed to assess and compare selected cytokines, miRNAs, and oxidative stress biomarker levels between patients with MDD, first-degree relatives (FDRs), and unrelated healthy controls (UHCs).

Paraphilias, encompassing a diverse range of atypical sexual interests and behaviors, have been a subject of profound interest and scrutiny throughout history. These sexual interests are a matter of debate with the changing society and also with the changing world view. The rise in awareness about abnormal sexual interests also poses difficulty in adding to the existing list.

Little is empirically known about how young children understand death or how this perception is affected by their attachment to parents.

The objective of this study was to do a meta-analysis focusing on the efficacy of psychological intervention for the adolescent population and PTSD as a primary outcome variable.

Psychiatric morbidities often go unnoticed in medically ill patients. It is essential to screen patients with medical morbidity so that they can be referred to psychiatrists for early interventions in general hospitals in India. There is a potential lacuna in terms of the availability of a scale that can aptly identify psychiatric symptoms in medically ill patients beyond depression or anxiety, especially in low-resource settings like India.

Little information exists about the association between alcohol and tobacco use and self-reported depressed mood, such as feeling sad, blue, or depressed days (SBDD), among older adults in India.

The first two years of life are critical for brain development. Experiences and exposures during this period can have long-term effects on an individual's health. Therefore, we aim to develop a program for new parents in the Indian context to help them understand their developing infant's needs and provide the best possible care grounded in traditional practices to ensure healthy developmental outcomes.

The P300 is a positive auditory event-related potential appearing around 300 msec post-oddball stimulus onset. Tone and monosyllabic stimuli have been widely used in P300 research, providing valuable insights into auditory perception, phoneme discrimination, language processing, and other cognitive processes. Bi-syllabic minimal pairs may be more challenging for some individuals because they require processing and discrimination of more complex phonemic structures. The aim of the study was to elicit and analyze the auditory event-related potentials for bi-syllabic word stimuli in the Kannada language among individuals with dementia.

Schizophrenia and bipolar disorder are understood to have neuroinflammatory/neuro-immunological basis in their etiopathogenesis. There are few studies synthesizing the association of schizophrenia and bipolar disorder in type 1 diabetes mellitus (T1DM), a common immunological disorder.

Disulfiram is a US FDA-approved medication for the management of alcohol use disorder. However, compliance with disulfiram has been the Achilles' heel of its efficacy. Implantation and surreptitious administration of disulfiram are two methods occasionally used to ensure disulfiram compliance. We present the case of a 45-year-old man who underwent disulfiram implantation. Upon consuming his first drink after this procedure, his wife administered him a hefty dose of disulfiram tablets surreptitiously. The patient subsequently developed a state of fluctuating orientation, marked impairment in attention and concentration, dyscalculia, along with memory and motor deficits. The diagnostic dilemma associated with such a presentation, along with the ethical violations and medical risks associated with implantation and surreptitious use, is discussed. Disulfiram-associated encephalopathy is a rare consequence of disulfiram use and was precipitated in this patient by the administration of disulfiram using the above methods.

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that is effective and safe for the treatment of depression. We observed improvement in insomnia along with symptoms of depression following high-frequency rTMS over the left dorsolateral prefrontal cortex in a patient with treatment-resistant depression, which progressed to excessive daytime sleepiness during the treatment sessions. Causality assessment suggested a probable association of rTMS with excessive sleepiness. The implications of the effect of rTMS on sleep are discussed.