acetylcholinesterase inhibitors 乙酰胆碱酯酶抑制剂

介绍：

“Acetylcholine’s action can be terminated by two different enzymes: acetylcholinesterase (AChE), which is present both intra- and extracellularly, and butyrylcholinesterase (BuChE), which is particularly present in glial cells. Both enzymes convert acetylcholine into choline, which is then transported out of the synaptic cleft and back into the presynaptic neuron via the choline transporter. Once inside the presynaptic neuron, choline can be recycled into acetylcholine and then packaged into vesicles by the vesicular acetylcholine transporter (VAChT).” (Stahl, 2021) 乙酰胆碱的作用可以通过两种不同的酶来终止：乙酰胆碱酯酶( AChE )和丁酰胆碱酯酶( BuChE )。这两种酶将乙酰胆碱转化为胆碱，胆碱再通过胆碱转运体转运出突触间隙并返回突触前神经元。一旦进入突触前神经元，胆碱可以再循环成乙酰胆碱，然后被囊泡乙酰胆碱转运体( VAChT )包装成囊泡。