Diagnostic Requirements #

Essential (Required) Features: #

• At least two of the following symptoms must be present (by the individual’s report or through observation by the clinician or other informants) most of the time for a period of 1 month or more. At least one of the qualifying symptoms should be from item a) through d) below:

1. Persistent delusions (e.g., grandiose delusions, delusions of reference, persecutory delusions).
2. Persistent hallucinations (most commonly auditory, although they may be in any sensory modality).
3. Disorganized thinking (formal thought disorder) (e.g., tangentiality and loose associations, irrelevant speech, neologisms). When severe, the person’s speech may be so incoherent as to be incomprehensible (‘word salad’).
4. Experiences of influence, passivity or control (i.e., the experience that one’s feelings, impulses, actions or thoughts are not generated by oneself, are being placed in one’s mind or withdrawn from one’s mind by others, or that one’s thoughts are being broadcast to others).
5. Negative symptoms such as affective flattening, alogia or paucity of speech, avolition, asociality and anhedonia.
6. Grossly disorganized behaviour that impedes goal-directed activity (e.g., behaviour that appears bizarre or purposeless, unpredictable or inappropriate emotional responses that interferes with the ability to organize behaviour.)
7. Psychomotor disturbances such as catatonic restlessness or agitation, posturing, waxy flexibility, negativism, mutism, or stupor. Note: If the full syndrome of Catatonia is present in the context of Schizophrenia, the diagnosis of Catatonia Associated with Another Mental Disorder should also be assigned.

• The symptoms are not a manifestation of another medical condition (e.g., a brain tumour) and are not due to the effects of a substance or medication (e.g., corticosteroids) on the central nervous system, including withdrawal effects (e.g., from alcohol).

Course specifiers for Schizophrenia: #

The following specifiers should be applied to identify the course of Schizophrenia, including whether the individual currently meets the diagnostic requirements of Schizophrenia or is in partial or full remission. Course specifiers are also used to indicate whether the current episode is the first episode of Schizophrenia, whether there have been multiple such episodes, or whether symptoms have been continuous over an extended period of time.

6A20.0 Schizophrenia, first episode精神分裂症，首次发作 #

• The first episode specifier should be applied when the current or most recent episode is the first manifestation of Schizophrenia meeting all diagnostic requirements in terms of symptoms and duration. If there has been a previous episode of Schizophrenia or Schizoaffective Disorder, the ‘multiple episodes’ specifier should be applied.精神分裂症，首次发作应被用来确定那些出现符合精神分裂症诊断要求的症状（包括持续时间），但以前从未经历过精神分裂症发作的患者。

6A20.00 Schizophrenia, first episode, currently symptomatic精神分裂症，首次发作，目前为症状性 #

• All diagnostic requirements for Schizophrenia in terms of symptoms and duration are currently met, or have been met within the past 1 month.
• There have been no previous episodes of Schizophrenia or Schizoaffective Disorder.Note: If the duration of the episode is more than 1 year, the ‘continuous’ specifier may be used instead, depending on the clinical situation.
• 患者的症状和病程目前满足或前一个月内曾经满足精神分裂症，首次发作定义的全部要求。

A20.01 Schizophrenia, first episode, in partial remission精神分裂症，首次发作，部分缓解 #

• The full diagnostic requirements for Schizophrenia have not been met within the past month, but some clinically significant symptoms remain, which may or may not be associated with functional impairment.
• There have been no previous episodes of Schizophrenia or Schizoaffective Disorder.Note: This category may also be used to designate the re-emergence of subthreshold symptoms of Schizophrenia following an asymptomatic period in a person who has previously met the diagnostic requirements for Schizophrenia.
• 患者症状和病程曾经满足精神分裂症，首次发作的全部定义要求。症状缓解，至少一个月已不满足精神分裂症诊断要求，但仍有临床显著症状，伴或不伴功能损害。部分缓解可能是对药物或其他治疗的反应。

6A20.02 Schizophrenia, first episode, in full remission精神分裂症，首次发作，完全缓解 #

• The full diagnostic requirements for Schizophrenia have not been met within the past month, and no clinically significant symptoms remain.
• There have been no previous episodes of Schizophrenia or Schizoaffective Disorder.
• 患者症状和病程曾经满足精神分裂症，首次发作的全部定义要求。症状缓解，没有临床显著症状。完全缓解可能是对药物或其他治疗的反应。

6A20.0Z Schizophrenia, first episode, unspecified未特指的精神分裂症，首次发作 #

6A20 Schizophrenia, multiple episodes精神分裂症，多次发作 #

• The multiple episodes specifier should be applied when there has been a minimum of two episodes meeting all diagnostic requirements of Schizophrenia or Schizoaffective Disorder in terms of symptoms, with a period of partial or full remission between episodes lasting at least 3 months, and the current or most recent episode is Schizophrenia. Note that the 1-month duration requirement for the first episode does not necessarily need to be met for subsequent episodes. During the period of remission, the diagnostic requirements of Schizophrenia are either only partially fulfilled or absent.精神分裂症，多次发作应被用来识别那些出现符合精神分裂症诊断要求症状的，并且以前也有过符合诊断要求的发作，在两次发作之间症状有实质性缓解的人。在缓解期，一些减轻的症状可能仍然存在，而且缓解可能是对药物治疗或其他治疗的反应。

6A20.10 Schizophrenia, multiple episodes, currently symptomatic精神分裂症，多次发作，目前为症状性 #

• All symptom requirements for Schizophrenia are currently met, or have been met within the past month. Note that the 1-month duration requirement for the first episode does not necessarily need to be met for subsequent episodes.
• There have been a minimum of two episodes of Schizophrenia or a previous episode of Schizoaffective Disorder, with a period of partial or full remission between episodes lasting at least 3 months.
• 患者的症状和病程目前满足或前一个月内曾经满足精神分裂症，多次发作定义的全部要求。

6A20.11 Schizophrenia, multiple episodes, in partial remission精神分裂症，多次发作，部分缓解 #

• The full diagnostic requirements for Schizophrenia have not been met within the past month, but some clinically significant symptoms remain, which may or may not be associated with functional impairment.
• There have been a minimum of two episodes of Schizophrenia or a previous episode of Schizoaffective Disorder, with a period of partial or full remission between episodes lasting at least 3 months.Note: This category may also be used to designate the re-emergence of subthreshold symptoms of Schizophrenia following an asymptomatic period.
• 患者症状和病程曾经满足精神分裂症，多次发作定义的全部要求。症状缓解，至少一个月已不满足精神分裂症诊断要求，但仍有临床显著症状，伴或不伴功能损害。部分缓解可能是对药物或其他治疗的反应。

6A20.12 Schizophrenia, multiple episodes, in full remission精神分裂症，多次发作，完全缓解 #

• The full diagnostic requirements for Schizophrenia have not been met within the past month, and no clinically significant symptoms remain.
• There have been a minimum of two episodes of Schizophrenia or a previous episode of Schizoaffective Disorder, with a period of partial or full remission between episodes lasting at least 3 months.
• 患者症状和病程曾经满足精神分裂症，多次发作的全部定义要求。症状缓解，没有临床显著症状。完全缓解可能是对药物或其他治疗的反应。

6A20.1Z Schizophrenia, multiple episodes, unspecified未特指的精神分裂症，多次发作 #

6A20.2 Schizophrenia, continuous精神分裂症，持续性 #

• The continuous specifier should be applied when symptoms fulfilling all diagnostic requirements of Schizophrenia have been present for almost all of the course of the disorder during the person’s lifetime since its first onset, with periods of subthreshold symptoms being very brief relative to the overall course. In order to apply this specifier to a first episode, the duration of Schizophrenia must be at least 1 year. In that case, the continuous specifier should be applied instead of the first episode specifier.满足精神分裂症定义全部要求的症状在至少一年时间里持续存在于几乎整个病程中，阈下症状期相较整体病程非常短暂。

6A20.20 Schizophrenia, continuous, currently symptomatic精神分裂症，连续病程，目前为症状期 #

• All symptom requirements for Schizophrenia are currently met, or have been met within the past month.
• Symptoms meeting the diagnostic requirements for Schizophrenia have been present for almost all of the course of the disorder during the person’s lifetime since its first onset.
• Periods of partial or full remission have been very brief relative to the overall course and none have lasted for three months or longer.
• To apply the continuous specifier to a first episode, symptoms meeting the diagnostic requirements for Schizophrenia must have been present for at least 1 year.
• 患者的症状和病程目前满足或前一个月内曾经满足精神分裂症，持续性定义的全部要求。

6A20.21 Schizophrenia, continuous, in partial remission精神分裂症，持续性，部分缓解 #

• The full diagnostic requirements for Schizophrenia, continuous were previously met but have not been met within the past month.
• Some clinically significant symptoms of Schizophrenia remain, which may or may not be associated with functional impairment.Note: This category may also be used to designate the re-emergence of subthreshold symptoms of Schizophrenia following an asymptomatic period.
• 患者症状和病程曾经满足精神分裂症，持续性定义的全部要求。症状缓解，至少一个月已不满足精神分裂症诊断要求，但仍有临床显著症状，伴或不伴功能损害。部分缓解可能是对药物或其他治疗的反应。

6A20.22 Schizophrenia, continuous, in full remission精神分裂症，持续性，完全缓解 #

• The full diagnostic requirements for Schizophrenia, continuous were previously met but have not been met within the past month.
• No clinically significant symptoms of Schizophrenia remain.
• 患者症状和病程曾经满足精神分裂症，持续性的全部定义要求。症状缓解，没有临床显著症状。完全缓解可能是对药物或其他治疗的反应。

6A20.2Z Schizophrenia, continuous, unspecified未特指的精神分裂症，持续性 #

6A20.Y Other specified episode of Schizophrenia精神分裂症其他特指的发作 #

6A20.Z Schizophrenia, episode unspecified精神分裂症，未特指的发作 #

Additional Clinical Features: #

• The onset of Schizophrenia may be acute, with serious disturbance apparent within a few days, or insidious, with a gradual development of signs and symptoms.
• A prodromal phase often precedes the onset of psychotic symptoms by weeks or months. The characteristic features of this phase often include loss of interest in work or social activities, neglect of personal appearance or hygiene, inversion of the sleep cycle and attenuated psychotic symptoms, accompanied by negative symptoms, anxiety/agitation or varying degrees of depressive symptoms.
• Between acute episodes there may be residual phases, which are similar phenomenologically to the prodromal phase.
• Schizophrenia is frequently associated with significant distress and significant impairment in personal, family, social, educational, occupational or other important areas of functioning. However, distress and psychosocial impairment are not requirements for a diagnosis of Schizophrenia.

Boundary with Normality (Threshold): #

• Psychotic-like symptoms or unusual subjective experiences may occur in the general population, but these are usually fleeting in nature and are not accompanied by other symptoms of Schizophrenia or a deterioration in psychosocial functioning. In Schizophrenia, multiple persistent symptoms are present and are typically accompanied by impairment in cognitive functioning and other psychosocial problems.

Course Features: #

• The course and onset of Schizophrenia is variable. Some experience exacerbations and remission of symptoms periodically throughout their lives, others a gradual worsening of symptoms, and a smaller proportion experience complete remission of symptoms.
• Positive symptoms tend to diminish naturally over time, whereas negative symptoms often persist and are closely tied to poorer prognosis. Cognitive symptoms also tend to be more persistent and when present are associated with ongoing functional impairment.
• Early-onset Schizophrenia is typically associated with a poorer prognosis whereas affective and social functioning are more likely to be preserved with later onset.

Developmental Presentations: #

• Onset of fully symptomatic Schizophrenia before puberty is extremely rare and when it occurs it is often preceded by a decline in social and academic functioning, odd behaviour, and a change in affect observable during the prodromal phase. Childhood onset is also associated with a greater prevalence of delays in social, language or motor development and co-occurring Disorder of Intellectual Development or Developmental Learning Disorder.
• In children and young adolescents, auditory hallucinations most commonly occur as a single voice commenting on or commanding behaviour whereas in adults such hallucinations are more typically experienced as multiple conversing voices.
• In children and adolescents, it may be challenging to differentiate delusions and hallucinations from more developmentally typical phenomena (e.g., a ‘monster’ under the child’s bed, an imaginary friend), actual plausible life experiences (e.g., being teased or bullied at school), and irrational or magical thinking common in childhood (e.g., that thinking about something will make it happen).
• Among children with Schizophrenia, negative symptoms, hallucinations, and disorganized thinking—including loose associations, illogical thinking, and paucity of speech—tend to be prominent features of the clinical presentation. Disorganized thinking and behaviour occur in a variety of disorders that are common in childhood (e.g., Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder), which should be considered before attributing the symptoms to the much less common childhood Schizophrenia.

Culture-Related Features: #

• Cultural factors may influence the onset, symptom pattern, course, and outcome of Schizophrenia. For example, among migrants and ethnic and cultural minorities, living in areas with a low proportion of their own ethnic, migrant or cultural group (low ‘ethnic density’) is associated with higher rates of Schizophrenia. In addition, etiological or course-related factors may be impacted by culture at the level of the family (e.g., level of family support, style of family interaction, such as expressed emotion) or at the societal level (e.g., industrialization, urbanization). For example, the prevalence of Schizophrenia is much higher in urban than rural settings.
• The risk of misdiagnosing the expression of distress as indicative of Schizophrenia or Other Primary Psychotic Disorder may be increased among ethnic minorities and immigrants, and in other situations in which the clinician is unfamiliar with culturally normative expressions of distress. These include situations involving spiritual or supernatural beliefs or resulting from migration trauma, social isolation, minority and acculturative stress, discrimination, and victimization.

Sex- and/or Gender-Related Features: #

• Schizophrenia is more prevalent among males.
• The age of onset of the first psychotic episode differs by gender with a greater proportion of males experiencing onset in their early to mid 20s and females in their late 20s.
• Females with Schizophrenia tend to report more positive symptoms that increase in severity over the course of their lives. Females also tend to have greater mood disturbance and a greater prevalence of subsequent or co-occurring mental disorders (e.g., Schizoaffective Disorder, Depressive Disorders).
• Females with Schizophrenia are less likely to exhibit disorganized thinking, negative symptoms, and social impairment.

Boundaries with Other Disorders and Conditions (Differential Diagnosis): #

• Boundary with Schizoaffective Disorder: The diagnoses of Schizophrenia and Schizoaffective Disorder are intended to apply to the current or most recent episode of the disorder. In other words, a previous diagnosis of Schizoaffective Disorder does not preclude a diagnosis of Schizophrenia, and vice versa. In both Schizophrenia and Schizoaffective Disorder, at least two the characteristic symptoms of Schizophrenia are present most of the time for a period of 1 month or more. In Schizoaffective Disorder, the symptoms of Schizophrenia are present concurrently with mood symptoms that meet the full diagnostic requirements of a Mood Episode and last for at least 1 month and the onset of the psychotic and mood symptoms is either simultaneous or occurs within a few days of one another. In Schizophrenia, co-occurring mood symptoms, if any, either do not persist for as long as 1 month or are not of sufficient severity to meet the requirements of a Moderate or Severe Depressive Episode, a Manic Episode, or a Mixed Episode. (See Mood Episode Descriptions) An episode that initially meets the diagnostic requirements for Schizoaffective Disorder in which only the mood symptoms remit, so that the duration of psychotic symptoms without mood symptoms is much longer than the duration of concurrent symptoms, may be best characterized as an episode of Schizophrenia.
• Boundary with Acute and Transient Psychotic Disorder: The psychotic symptoms in Schizophrenia persist for at least 1 month in their full, florid form. In contrast, the symptoms in Acute and Transient Psychotic Disorder tend to fluctuate rapidly in intensity and type across time, such that the content and focus of delusions or hallucinations often shift, even on a daily basis. Such rapid shifts would be unusual in Schizophrenia. Negative symptoms are often present in Schizophrenia, but do not occur in Acute and Transient Psychotic Disorder. The duration of Acute and Transient Psychotic Disorder does not exceed 3 months, and most often lasts from a few days to 1 month, as compared to a much longer typical course for Schizophrenia. In cases that meet the diagnostic requirements for Schizophrenia except that they have lasted less than the duration required for a diagnosis (i.e., 1 month) in the absence of a previous history of Schizophrenia, a diagnosis of Other Specified Primary Psychotic Disorder and not Acute and Transient Psychotic Disorder should be assigned.
• Boundary with Schizotypal Disorder: Schizotypal Disorder is characterized by an enduring pattern of unusual speech, perceptions, beliefs and behaviours that resemble attenuated forms of the defining symptoms of Schizophrenia. Schizophrenia is differentiated from Schizotypal Disorder based entirely on the intensity of the symptoms; Schizophrenia is diagnosed if the symptoms are sufficiently intense to meet diagnostic requirements.
• Boundary with Delusional Disorder: Both Schizophrenia and Delusional Disorder may be characterized by persistent delusions. If other features are present that meet the diagnostic requirements of Schizophrenia (i.e., persistent hallucinations; disorganized thinking; experiences of influence, passivity, or control; negative symptoms; disorganized or abnormal psychomotor behaviour), a diagnosis of Schizophrenia should be made instead of a diagnosis of Delusional Disorder. However, hallucinations that are consistent with the content of the delusions and do not occur persistently (i.e., with regular frequency for 1 month or longer) are consistent with a diagnosis of Delusional Disorder rather than Schizophrenia. Delusional Disorder is generally characterized by relatively preserved personality and less deterioration and impairment in social and occupational functioning in comparison with Schizophrenia, and individuals with Delusional Disorder tend to come to clinical attention for the first time at a later age. Individuals with symptom presentations consistent with Delusional Disorder (e.g., delusions and related, circumscribed hallucinations) but who have not met the minimum duration requirement of 3 months should not be assigned a diagnosis of Schizophrenia even though the combination of persistent delusions and related hallucinations technically meets diagnostic requirements for Schizophrenia. Instead, a diagnosis of Other Specified Primary Psychotic Disorder is more appropriate in such cases.
• Boundary with Moderate or Severe Depressive Episodes in Single Episode Depressive Disorder, Recurrent Depressive Disorder, Bipolar Type I Disorder, and Bipolar Type II Disorder: Psychotic symptoms may also occur during Moderate or Severe Depressive Episodes. Delusions during Depressive Episodes may resemble delusions observed in Schizophrenia and are commonly persecutory or self-referential (e.g., being pursued by authorities because of imaginary crimes). Delusions of guilt (e.g., falsely blaming oneself for wrongdoings), poverty (e.g., of being bankrupt) or impending disaster (perceived to have been brought on by the individual), as well as somatic delusions (e.g., of having contracted some serious disease) and nihilistic delusions (e.g., believing body organs do not exist) are also known to occur. Experiences of passivity, influence or control (e.g., thought insertion, thought withdrawal, or thought broadcasting) may also occur in Moderate or Severe Depressive Episodes. Hallucinations are usually transient and rarely occur in the absence of delusions. Auditory hallucinations (e.g., derogatory or accusatory voices that berate the individual for imaginary weaknesses or sins) are more common than visual (e.g., visions of death or destruction) or olfactory hallucinations (e.g., the smell of rotting flesh). However, in a Moderate or Severe Depressive Episode with psychotic symptoms, the psychotic symptoms are confined to the Mood Episode. Schizophrenia is differentiated from Depressive Episodes in Mood Disorders by the occurrence of psychotic and other symptoms that meet the diagnostic requirements of Schizophrenia during periods without mood symptoms that meet the diagnostic requirements of a Moderate or Severe Depressive Episode. If the diagnostic requirements for both Schizophrenia and a Moderate or Severe Depressive Episode are met concurrently and both the psychotic and mood symptoms last for at least 1 month, Schizoaffective Disorder is the appropriate diagnosis.
• Boundary with Manic or Mixed Episodes in Bipolar Type I Disorder: Psychotic symptoms may occur during Manic or Mixed Episodes in Bipolar Type I Disorder. Though all types of psychotic symptoms are known to occur in Manic or Mixed Episodes, grandiose delusions (e.g., being chosen by God, having special powers or abilities), and persecutory and self-referential delusions (e.g., being conspired against because of one’s special identity or abilities) are among the most common. Experiences of influence, passivity or control (e.g., thought insertion, thought withdrawal, or thought broadcasting) may also occur during Manic or Mixed Episodes. Hallucinations are less frequent and commonly accompany delusions of persecution or reference. They are usually auditory (e.g., adulatory voices), and less commonly visual (e.g., visions of deities), somatic, or tactile. However, in a Manic or Mixed Episode with psychotic symptoms, the psychotic symptoms are confined to the Mood Episode. Schizophrenia is differentiated from Manic or Mixed Episodes in Bipolar Type I Disorder by the occurrence of psychotic and other symptoms that meet the diagnostic requirements of Schizophrenia during periods without mood symptoms that meet the diagnostic requirements of a Manic or Mixed Episode. If the diagnostic requirements for both Schizophrenia and Bipolar Type I Disorder are met concurrently and both psychotic and mood symptoms last for at least 1 month, Schizoaffective Disorder is the appropriate diagnosis.
• Boundary with Post-Traumatic Stress Disorder and Complex Post-Traumatic Stress Disorder: In Post-Traumatic Stress Disorder and Complex Post-Traumatic Stress Disorder, severe flashbacks that involve a complete loss of awareness of present surroundings may occur, intrusive images or memories may have a hallucinatory quality, and hypervigilance may reach proportions that appear to be paranoid. However, the diagnoses of Post-Traumatic Stress Disorder and Complex Post-Traumatic Stress Disorder require a history of exposure to an event or series of events (either short- or long-lasting) of an extremely threatening or horrific nature. These diagnoses also require re-experiencing of the traumatic event in the present, in which the event is not just remembered but rather experienced as occurring again in the here and now, and may include loss of awareness and hallucination-like experiences within this specific context. Re-experiencing of traumatic events is not a characteristic feature of Schizophrenia. However, Post-Traumatic Stress Disorder and Schizophrenia frequently co-occur, and both diagnoses should be assigned when the diagnostic requirements for each are met.