The study aims to investigate whether manipulating levels of uncertainty would influence performance in a decision-making task in obsessive-compulsive disorder (OCD).

Suicide represents 1% of all deaths in the world. It's more prevalent in underdeveloped countries. Suicide mortality in Brazil has been growing in recent years. We Evaluated whether patients who committed suicide in Fortaleza sought the only psychiatric emergency service in the State before the act during the year 2022.

To measure the levels of functionality and QoL of caregivers of patients with BD, investigating the association between them, as well as the relationship with clinical and sociodemographic data of these caregivers.

Given the increasing number of people with dementia in Brazil, there is an urgency for health and social systems to plan strategies to meet the needs of this population and their families. Therefore, research on dementia costs is essential. This study estimated direct and indirect costs related to dementia in Brazil.

This study aims to assess the safety profile of Olanzapine by analyzing adverse events (AEs) reported in the FAERS database, particularly focusing on newly identified risks.

Social anxiety disorder (SAD) is one of the most prevalent anxiety disorders, often not well recognized. In most of the cases, SAD follows an unremitted and chronic course, affecting several areas of the individual functioning (i.e.: relationship, academic, work). Due to its relevance, there is a need for guideline-based treatments for SAD treatment adapted to the Brazilian social and economic reality.

We aimed to assess the effect of N-acetylcysteine (NAC), as an adjuvant treatment, on treatment adherence (primary outcome), in peripheral biomarkers and clinical improvement (secondary outcomes) in alcohol use disorders (AUD) patients.

To study the impacts of maternal depressive symptoms trajectories and harsh parenting and explore if the maternal quality of life mediates this association.

This study aimed to explore the association between major depressive disorder (MDD) and suicide risk in dementia patients.

This study investigates if moral harassment contributes to anxiety, depression and burnout among medical residents.

In this population-based cohort study, we compared the risks of incident hyperopia, myopia, astigmatism, and strabismus between children with autism spectrum disorder (ASD) and children without ASD.

This study aimed to assess longitudinal patterns of anxiety, depression, and posttraumatic stress symptoms, as well as their predictors, in a reference hospital workforce during the first two waves of the pandemic in Brazil.

We aim to evaluate whether a wide range of baseline mental disorders predict Internet Gaming Disorder (IGD) one to three years later, among university students.

To identify the effects of amygdala neuromodulation in the management disruptive behavior in patients, as well as changes in their quality of life and its relationship with epilepsy.

Depressive symptoms during perinatal significantly impact mothers and infants. Emerging evidence suggests a connection between gut microbiota and mood regulation. This study investigated whether depressive symptoms are associated with changes in the gut microbiota of women during the perinatal period.

Single-session interventions (SSI) are an effective strategy reducing emotional distress. Enhanced psychoeducation (EP), which includes empathic listening, risk stratification, symptom monitoring, and habit modification is particularly suitable for SSIs. We investigate predictors of response to an online EP intervention among essential service professionals during COVID-19 in Brazil. TELEPSI Project financed by the Ministry of Health of Brazil, nationwide initiative, which served more than 3,300 individuals in various psychotherapeutic modalities. Data from April 2020 to December 2021. We included all participants who received SSIs with high levels of emotional distress. Final sample: 460 subjects, 89.1% female, and 81.1% health professionals. 300 subjects underwent reassessment in one month. Participants with harmful use of social networks, spending time on social media, playing video games, smoking, drinking alcohol, spending time with pets had a less pronounced symptom decrease. Participants who played instruments or already received some psychological treatment showed a greater magnitude of symptom decrease. This highlighted the impact of lifestyle factors on the efficacy of SSIs. These results underscore the importance of considering individual lifestyle factors when implementing SSIs and contribute to growing body of evidence supporting the tailored application of psychoeducational strategies in mental health interventions, particularly in high-stress environments.

The large body of literature examining the association between parenthood and mortality in the general population contrasts with a lack of studies among older adults with schizophrenia. Identifying potential protective factors of premature death in this population is important to help guide prevention measures. Here, we examined whether all-cause and cause-specific mortality rates significantly differ between older adults with schizophrenia with and without children, during a 5-year follow-up.

Schizophrenia patients represent a heterogeneous group in clinical presentation and severity. Although severity has been operationalized in different ways, mostly on a gradient between symptom severity and functional impairment, such approaches are limited in capturing real-world functioning. We suggest adopting the severity model proposed by DSM-5 for autism spectrum disorders. The model defines three levels of severity, based on the support required, directly addressing two barriers from previous models: real-world functioning and ease of implementation. Our adapted model includes three new features: First, this severity specifier is global, rather than for each symptom domain. Second, the centrality of occupational functioning is emphasized to define the level of support. Third, we propose a one-month timeframe for severity appraisal, standardizing the assessment process. Considering practical utility, we indicate how severity assessment can guide clinical practice towards rehabilitation. Additionally, we outlined operational definitions for severity and functioning in schizophrenia, aligned with the premises of our model. Finally, we acknowledge potential limitations, the most relevant being the need for empirical validation. The model is presented to foster discussion. Additional studies will follow to investigate inter-rater reliability and convergent validation with standard measures of symptom and functioning severity.

Clinical nurses have symptoms of post-traumatic stress disorder (PTSD), anxiety and depression, which seriously affect their physical and mental health. Narrative therapy (NT), a therapy for trauma-related psychological disorders, may be an effective intervention.

Digital therapeutics have evolved rapidly with technological advances in healthcare. Despite their increasing use, gaps remain in understanding their regulatory frameworks, integration, and efficacy for conditions like substance use disorder, insomnia, attention deficit hyperactivity disorder, and post-traumatic stress disorder. This study evaluates FDA-approved digital therapeutics and explores their potential to revolutionize psychiatric treatments amid ongoing technological and regulatory changes. We conducted a comprehensive review of major databases, focusing on articles published up to January 2024 on FDA-approved digital therapeutics. We excluded non-English articles and those lacking empirical data or focusing on non-FDA-approved therapeutics. Our analysis covered regulatory compliance, clinical outcomes, and integration with traditional treatments. The review of nine FDA-cleared digital therapeutics revealed benefits like improved treatment accessibility and potential reductions in healthcare costs. For example, Somryst, a cognitive-behavioral therapy-based treatment for insomnia, showed that over 40 percent of users overcame chronic insomnia, and 60 percent experienced improvements without adverse effects. However, challenges remain, including low provider adoption, inadequate insurance coverage, and high user dropout rates. While digital therapeutics enhance accessibility, they face regulatory challenges, reimbursement issues, and the need for robust clinical evidence. Success depends on collaboration among stakeholders to demonstrate value, ensure safety, and integrate them into existing healthcare systems.

To examine the effect of nutritional counseling therapy (NCT) combined with transcranial direct current stimulation (tDCS) on Binge Eating Disorder (BED) symptoms.

Within the context of patients at-risk of psychosis, where a variety of symptoms are present, identifying the most discriminative symptoms is essential for efficient detection and management.

To investigate the association between depressive symptoms and social support among a representative sample of the Brazilian population aged 50 years or older.