American Journal of Translational Research

Analysis of independent risk factors for postpartum depression in elderly primiparas and the effects of mindfulness-based psychological intervention
Wu B, Wang N, Hu L and Wu G
To identify the independent risk factors for postpartum depression in elderly primiparas and to evaluate the effects of mindfulness-based psychological intervention.
Effectiveness of amplitude-integrated electroencephalography combined with neuron-specific enolase level in predicting neonatal brain injury and prognosis
Zhang X, Dai G and Li K
To investigate the value of amplitude-integrated electroencephalography (aEEG) combined with neuron-specific enolase (NSE) in the diagnosis and prognostic assessment of neonatal brain injury.
Application value of real-time shear wave elastography for quantitative evaluation of chronic kidney disease in pediatric patients
Zhang J, Liu L, Yang F and Liu J
To evaluate the effectiveness of real-time shear wave elastography (SWE) in quantitative evaluation of chronic kidney disease (CKD) in pediatric patients.
Predictive value of the triglyceride-glucose index for no-reflow phenomenon after percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction complicated by metabolic syndrome
Qu Z and Guan X
Acute ST-segment elevation myocardial infarction (STEMI) remains a major contributor to morbidity and mortality worldwide. The no-reflow phenomenon following percutaneous coronary intervention (PCI) complicates the clinical outcome of STEMI. This study aimed to identify a valuable predictor for no-reflow phenomenon.
Clinical value of rehabilitation nursing after internal fixation of distal radius fractures
Yuan L, Shao W, Yuan L and Ma J
To evaluate the clinical value of rehabilitation nursing following internal fixation of distal radius fractures (DRFs).
Efficacy of dexmedetomidine epidural anesthesia combined with nano-silver polyurethane dressing in gynecological surgery and its influence on hemodynamics, inflammatory response and postoperative recovery
Fang Y, Zhou F and Chai Y
To evaluate the effectiveness of dexmedetomidine epidural anesthesia combined with nano-silver polyurethane dressing in gynecological surgery.
Incidence and influencing factors for hypoglycemia in maintenance hemodialysis patients with diabetic kidney disease: a meta-analysis
Jiang F, Wu B, Qin Z, Xie Y, Yi N, Chen W and Xu H
The objective of this study was to evaluate the incidence of hypoglycemia in patients with diabetic kidney disease (DKD) undergoing maintenance hemodialysis (MHD) and to identify key factors influencing its occurrence. A comprehensive literature search was conducted across databases including CNKI, Wanfang data, VIP, SinoMed, PubMed, Cochrane Library, Web of Science and Embase from their inception to March 31, 2023. The search focused on studies addressing the incidence and influencing factors for hypoglycemia in DKD patients receiving hemodialysis. Eligible studies were selected based on predefined inclusion and exclusion criteria, and data were analyzed using Stata 15.0 software. A total of 24 studies involving 2388 patients were included in this meta-analysis, with 22 studies from China and 2 studies from English-speaking countries. The findings indicated that the incidence of hypoglycemia among hemodialysis patients with DKD was 41.7% (95% confidence interval (): 32.6% to 50.9%). Influencing factors associated with hypoglycemia in hemodialysis patients with DKD included age (odds ratio (OR) = 4.507, 95% : 3.272 to 6.209), course of DKD ( = 3.547, 95% : 2.523 to 4.988), use of oral hypoglycemic drugs ( = 4.643, 95% : 2.566 to 8.402), fasting plasma glucose (FPG) levels (risk ratio (RR) = 4.033, 95% : 2.594 to 6.269), insulin use ( = 8.242, 95% : 4.517 to 15.042), application of glucose-free dialysate (RR = 7.987, 95% : 4.605 to 13.855), coefficient of variation in blood glucose (CVBG) ( = 3.241, 95% : 2.071 to 5.071), mean blood glucose (MBG) ( = 2.930, 95% : 1.635 to 5.248), medication compliance ( = 4.300, 95% : 2.047 to 9.031) and self-care ability ( = 3.543, 95% : 1.766 to 7.108). Specifically, risk factors identified were age > 60 years, DKD course > 1 year, use of oral hypoglycemic drugs, FPG < 6.1 mmol/L, insulin administration before dialysis, application of glucose-free dialysate, CVBG ≥ 0.26, MBG < 8.92 mmol/L, poor medication compliance, and poor self-care ability.
Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer
Cao M, Gu Y, Lv B, Liu S and Shen Y
To investigate the implications of serum hsa_circ_0007534 levels in ovarian cancer (OC) patients.
Effect of QingreHuoxue formula on Th17 cells and Tregs in mice with idiopathic membranous nephropathy
Lou C, Zhou Y, Liao J, Xu X, Huang K, Fan X, Hu P, Wang X, Feng B and Zhu F
This study aimed to evaluate the therapeutic effect of the QingreHuoxue formula on mice with Idiopathic Membranous Nephropathy (IMN) and its impact on Th17 cells and Tregs.
The antimicrobial effect of and in rats explains its utility in wound care
Khan MK, Khan IA, Iqbal MO, Eed EM, Ahmad A, Naeem M, Ashiq HT and Munawar N
, and are extensively used as household remedies for wound care for veterinary and human infectious diseases. However, little pharmacologic data is present to support this folklore. A series of and experiments were conducted to validate the folkloric practice of these herbs.
Predictive value of IL-10 and GFPA for postoperative prognosis in patients with brain glioma
Yu F, Fang X, Zhu J, Li B and Du B
To investigate the prognostic value of interleukin (IL)-10 and glial fibrillary acidic protein (GFPA) in patients with brain glioma following surgery.
Association between hip fracture fixation methods and bone mineral density T-value in middle-aged and elderly patients with hip fractures
Wang BW, Teng P and Xu LF
To examine the association of proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) with bone mineral density T-value (BMDT) in middle-aged and elderly patients suffering from hip fractures.
Dystrobrevin beta is a promising prognostic biomarker and therapeutic target for hepatocellular carcinoma
Sun J, Li Y, Bie B, Tian H, Li J, Yang L, Zhou Z, Mu Y and Li Z
Dystrobrevin beta (DTNB) is a constituent of the dystrophin-associated protein complex (DPC). Our previous RNA sequencing (RNA-seq) study revealed that knockdown of the oncogenic long noncoding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) in hepatocellular carcinoma (HCC) cells could reduce the expression levels of DTNB. However, the association between DTNB and HCC remains uncertain.
Effect of FOLFOX regimen combined with cetuximab treatment on the efficacy and tumor markers of advanced colon cancer patients
Zhang Y, Qian H, Cheng X, Zhou T, Zhong C, Tian F and Sun Q
To evaluate the efficacy of FOLFOX regimen combined with cetuximab in the treatment of advanced colon cancer.
Construction and validation of a novel nomogram for predicting spontaneous preterm birth in patients with gestational diabetes mellitus
Zhu J and Xie Y
To explore the influencing factors of spontaneous preterm birth (sPTB) in patients with gestational diabetes mellitus (GDM) and construct a nomogram model.
Multimodal ultrasound plus tumor markers demonstrates a high value in enhanced diagnosis of breast cancer
Li N, Li M and Zhou F
To determine the diagnostic value of multimodal ultrasound combined with tumor markers in breast cancer (BC).
Factors influencing bloodstream infections after immunosuppressive therapy in patients with aplastic anemia: a logistic regression analysis
Li J, Xue C, Liu G, Gao G and Wei D
To analyze the risk factors for bloodstream infection after immunosuppressive therapy in patients with aplastic anemia using logistic regression.
Preoperative CT radiomic model combined with clinical and CT imaging features to predict the spread through air spaces in T1 invasive lung adenocarcinoma
Xu P, Yu H, Zhao H, Bian H, Jia D, Zhi S and Peng X
This study aimed to explore the effectiveness of preoperative computed tomography (CT) radiomic models combined with clinical and CT imaging features for predicting spread through air spaces (STAS) in patients with T1 lung adenocarcinoma.
Glycyrrhizin inhibits LPS-induced neutrophil-like release of NETs
Shen Z, Gu J, Jiang B, Long H, Li Z, Chen C, Pei Z and Xia F
To investigate the regulatory effect of glycyrrhizin (GL) on the release of neutrophil extracellular traps (NETs) from neutrophils in sepsis.
Anticoagulation approaches for arterial and venous thrombotic occurrences in membranous nephropathy: report of a patient with postponed diagnosis
Huang F, Lan X, Xu X, Li S and Huang J
Vascular thrombosis and hypercoagulability are frequently observed in individuals with nephrotic syndrome (NS), particularly those diagnosed with membranous nephropathy (MN). It is extensively recognized that venous thrombosis occurs far more frequently than arterial thrombosis. However, we report a patient who experienced two significant arterial and venous thrombotic events within the past two years, and he was a 35-year-old man with nephrotic syndrome secondary to membranous nephropathy. In contrast to most previous similar studies that had shown only a single demonstration of venous embolism or arterial embolism, this case highlighted the occurrence of both venous and arterial embolic events. This suggests and prompts considerations for future research avenues and anticoagulant treatment strategies.
Exploration of BRCA1 and BRCA2 mutations in gastric cancer patients through next generation sequencing: implications for diagnosis and therapy
Ahmed I, Anwar S, Akram MA, Zeb U, Bharadwaj A, Zia R, Usman MA, Almutairi SM, Al Farraj DA, Aljarba NH, Alkhateeb MA and Alshammeri AF
The study aims to characterize BRCA1/2 mutations in Pakistani gastric cancer (GC) patients, identifying unique pathogenic variants and evaluating their potential as diagnostic biomarkers, while also exploring therapeutic avenues for personalized treatment strategies.