The review deals with the controversy surrounding the use of highly realistic dolls with a child-like appearance. It summarizes recent empirical findings and provides an overview of the different legal and ethical perspectives on this issue. Countries use different legal approaches to regulate the use or sale of child-like sex dolls. Although a causal link is assumed by some legislators between the prohibition of such dolls and the protection of children from sexual abuse, empirical studies do not support this causality. The imposition of bans will hinder empirical research on the potential use of alternative sexual outputs for people with paraphilic disorders.

Introduced in the late 1990s, nerve grafting, particularly with sural and genitofemoral nerves, aims to enhance erectile function recovery when neurovascular bundles cannot be preserved following radical prostatectomy. Over the past three decades, researchers have conducted numerous animal and clinical studies to explore the application and clinical effectiveness of this method, with the hope of benefiting patients suffering from erectile dysfunction after radical prostatectomy. Animal studies have demonstrated the potential of various grafting materials, including autologous nerve and vein grafts, and bioengineered grafts, in promoting nerve regeneration and erectile function recovery. Clinical studies, especially those focusing on sural and genitofemoral nerve grafts, have shown mixed results with varied success rates due to methodological weaknesses and small sample sizes. This review thoroughly incorporates current data, explores emerging nerve grafting methods, demonstrates the complexity of nerve grafting outcomes, and emphasizes the necessity for continuous research, including multi-institutional randomized controlled trials, to establish standardized protocols and optimize patient selection for nerve grafting in the management of erectile dysfunction after radical prostatectomy.

The high prevalence of erectile dysfunction (ED) underscores the critical importance of interventions and preventive measures targeting potential risk factors, among which obesity stands out. Relative fat mass (RFM) emerges as a superior indicator for quantifying body fat compared to traditional metrics like body mass index (BMI) or waist circumference (WC). However, research on the relationship between RFM and ED is extremely limited. A total of 3627 participants from the National Health and Nutrition Examination Survey 2001-2004 were eligible for analysis. The RFM is calculated using the following formula: RFM = 64-(20×height/WC). Weighted multivariable logistic regression models were utilized to assess the correlation between RFM and ED, supplemented by smooth curve fitting to further explore the linear association. When all potential covariates adjusted, continuous RFM demonstrated a positive association with ED prevalence (odds ratio (OR): 1.11, 95% confidence interval (CI): 1.05-1.18, P = 0.002). When RFM was categorized into tertiles (T1-T3), participants in T3 group exhibited a significantly higher likelihood of ED (OR: 2.19, 95% CI: 1.19, 4.05, P = 0.020) compared to those in T1. Subgroup analyses revealed a stronger correlation among participants aged over 60 years, obese individuals, and those with hypertension, while weaker correlations were observed among those with diabetes and cardiovascular disease (CVD). After sensitivity analysis for severe ED, the aforementioned regression analysis results remained statistically significant. The final ROC analysis demonstrated that the predictive ability of RFM was superior to that of BMI and WC, with an AUC (95% CI) of 0.639 (0.619-0.659). Elevated RFM demonstrated a linear correlation with increased incidence of ED and exhibited strong predictive capability for ED, underscoring the importance of obesity intervention for ED. Future studies with larger clinical samples are necessary to confirm our findings and expand the application value of RFM in assessing ED risk.

Female orgasmic experience and intensity depend on several biological, anatomical, cultural, psychological and relational factors, yet studies have not explored how receptiveness to different stimulations (clitoral, vaginal, or both) affects subjectively perceived orgasmic intensity. Using data from sexually active, heterosexual women in two Italian nationwide surveys from 2021 and 2023, we evaluated orgasmic experience, sexual and psychological well-being using validated psychometric tools (FSFI, Orgasmometer, GAD-7, PHQ-9), also considering several socio-demographic factors, aiming to identify changes in terms of subjectively perceived orgasmic intensity according to different stimulations. The two surveys (Sex@COVID study, from April 7 to May 4, 2020, n = 6821; and the FATHER Study, from May 12 to June 12, 2023, n = 1845) were hosted on a dedicated website and were advertised through social media, radio broadcast, and interviews on national newspapers. Among 1,799 women meeting inclusion criteria, 40.7% primarily experienced clitorally activated orgasms (CAO, n = 733), 18% vaginally activated orgasms (VAO, n = 324), and 41.2% both types (Clitorally and Vaginally Activated Orgasms, CaVAO, n = 742). Significant psycho-sexological differences between the two studies were observed, with additional evidence suggesting the impact of lockdown and social distancing on sexual outcomes. Women experiencing CaVAO attained the highest FSFI and Orgasmometer scores, followed by those with VAO, and lastly, those with CAO (p < 0.001 for both). Regression analysis confirmed the same trend for Orgasmometer scores (R = 0.247, p < 0.001), also highlighting the relevance of sexual dysfunction (according to FSFI, β = -1.34 ± 0.08, p < 0.001) for orgasmic intensity. Lastly, women preferring masturbation to partnered sexual activity had lower orgasmic intensity (β = -0.41 ± 0.07, p < 0.001). Age, psychological status and relationship status had no significant effect on the model. Despite some limitations, this is the first study addressing the association between receptiveness to different stimulations and orgasmic intensity on a large sample using validated psychometric instruments.

In recent decades, the assessment of male sexual function has been a subject of enduring interest. The use of the RigiScan®, a conventional diagnostic tool designed to differentiate between psychological and organic causes of erectile dysfunction (ED), has decreased due to several disadvantages. In this study, patient perspectives on the merits and drawbacks of the RigiScan®, as well as preferences for a future diagnostic device, were explored. Patients at St. Antonius Hospital and Leiden University Medical Center who underwent RigiScan® examinations were surveyed. A pretested questionnaire was used to gather data on their experiences, satisfaction levels, and suggestions for improvement. Among the 120 distributed questionnaires, a 39.2% response rate was achieved. The process of applying the RigiScan® around the penis was reported to have an average difficulty rating of 4.6 ± 2.5 (range: 1-9) points. While 74.5% of the participants were able to keep the device on all night, 25.5% of the participants experienced difficulties. Sleep quality was assessed at 5.5 ± 2.6 (range: 0-9) points. The participants reported an average pain rating of 4.7 ± 2.8 (range: 0-9) points. Despite these challenges, 69.6% of the participants reported that the device met their expectations, while 30.4% of the participants were dissatisfied. The key areas for improvement included device size (33.7%), user-friendliness (25.5%), sound (9.2%), hygiene (7.1%), and pain (6.1%). This study revealed that patients who underwent a nocturnal erectile function assessment with the RigiScan® device preferred a more patient-friendly and less intrusive diagnostic device. Further research is needed to determine whether a new sensor possessing these improved characteristics can increase patient satisfaction.

Gender-affirming surgery (GAS) is a highly personalized decision for transgender and gender diverse (TGD) individuals. However, the proportion of TGD individuals who desire GAS is unknown. A questionnaire was created after identifying themes surrounding experiences with gender-affirming medical care by community focus groups. Respondents who reported medically transitioning and who had undergone GAS were compared to those without prior GAS. From 88 completed surveys, 18 (20.5%) individuals did not wish to undergo GAS. Of those medically transitioning and desiring GAS, 15.2% (9/59) desired GAS but had not received it yet, with 6.7% (6/9) identifying as non-binary. Individuals who had not had GAS were more likely to earn under $15,000 annually, compared to $25,000-49,000 in the GAS group (p = 0.01). There was no significant difference in educational level (p = 0.32) or insurance status (p = 0.33). Of TGD individuals who desire GAS, out-of-pocket expenses such as hair removal, opaque insurance policies, lack of social support, and access to gender-affirming providers can hinder the transition process. Understanding barriers and rationales for pursuing GAS can provide targets for improving healthcare delivery to this diverse population.

Penile cancer is a rare malignancy (0.5-0.93/100,000 in Western countries) with significant psychosocial and sexual repercussions. This qualitative study explored the impact of penile cancer diagnosis and treatment on intimacy. A convenience sample was identified of 20 potential candidates who were at least 5 months post penile cancer surgery at a hospital centralizing penile cancer care. Participants were recruited by telephone and admitted until data saturation was reached, resulting in a sample of nine men (44-74 years old), none withdrew from participation. All interviews were performed by the same female researcher with no prior relationship to the men. The one-time interviews (35-61 min) followed a semi-structured interview guide, were audio-recorded and transcribed verbatim. Three researchers analysed the data independently using descriptive phenomenological analysis, resulting in a gradually drawn up coding tree mapping out the patient's journey. The central themes that emerged were: (1) Intimate area led to diagnostic delays, intensified diagnosis and induced secrecy; (2) Impact on sexuality prior to surgery; (3) The voyage of sexual re-discovery; (4) A partnered voyage of sexual discovery; (5) Care needs related to intimate area. This study highlights the need for comprehensive and personalized care, including pre-surgical information provision and post-surgical psychosexual support. Addressing the current unmet needs of men with penile cancer requires guidelines for psychosexual interventions and proactive efforts to reduce stigma and to raise awareness.