Health Policy, Planning, and Management: reflections based on CSP's experience
Educational strategies for preventing accidents in childhood: a systematic review
Accidents in childhood have a high morbidity and mortality rate and are often preventable, which reinforces the importance of educational measures to prevent unintentional injuries. This study aimed to identify and describe useful educational strategies for preventing childhood accidents in communities. This systematic review was guided by PRISMA (2020) and registered on the PROSPERO platform (ID: CRD42024500956). A search strategy was developed by combining the descriptors "Accident Prevention", "Child", and "Health Education" with the Boolean operator AND, applied to the PubMed/MEDLINE, Web of Science, LILACS, and SciELO databases. A total of 5,037 studies were located, including observational articles published from 2018 to 2023, with children aged 0-12 years and/or their parents/caregivers. The quality of the studies was assessed based on the Qualitative Studies Checklist and the Research Triangle Institute Item Bank instruments. The bibliographic sample consisted of 30 articles, mostly classified as high quality, with a population of 4,510 adults and 54,190 children from various countries. Educational strategies for accident prevention were described, aimed at parents and guardians, children, and both. This review, addressing innovative educational strategies for preventing childhood accidents, highlights playful approaches for children and visual methods for caregivers. Implementation faces challenges related to evaluation and socioeconomic factors, making rigorous criteria and prolonged follow-ups important for continuous effectiveness.
Socioeconomic inequalities in health problems in the first two years of life: Pelotas (Brazil) birth cohort, 2015
Brazil is characterized by an unfinished agenda of health inequalities, which impact health problems in the childhood. This study aimed to evaluate the socioeconomic inequalities of health problems in the early childhood. This is a prospective study, using data from the birth cohort carried out in the city of Pelotas (Rio Grande do Sul State, Brazil) in 2015. The outcomes were health problems presented at 12 and 24 months: cough, breathing difficulty, diarrhea, ear pain, pneumonia, urinary infection, hospitalization, and other health problems. Socioeconomic inequalities were measured applying the slope index of inequality (SII) and the concentration index (CIX), with wealth index and maternal schooling being the socioeconomic variables. The inequalities in the number of health problems were evaluated by Poisson regression. The perinatal sample comprised 4,275 children. At 12 months approximately 74% of the children presented 1 or more health problems, while at 24 months, approximately 44% presented 2 or more health problems. For all period, the mean number of health problems was 2.9 (standard deviation = 2.0). Higher frequencies were observed for children belonging to the poorest income quintile and with lower maternal education, except for 1 or more health problems at 24 months. The greatest absolute and relative inequality was observed for 2 or more health problems at 12 months (SII: -0.23, 95%CI: -0.29; -0.18 and CIX: -0.19, 95%CI: -0.25; -0.14). There is an opposite dose-response relation for the risk of accumulation of health problems according to maternal schooling (1.07, 95%CI: 1.04; 1.09) and wealth categories (1.03, 95%CI: 1.01; 1.04), in the full adjusted models. The study confirms inequalities due to health problems in Brazilian children, especially in the first year of life.
Spatial analysis of ischemic stroke in Spain: the roles of accessibility to healthcare and economic development
Ischemic stroke is a major cause of mortality worldwide; however, few studies have been conducted to measure the impact of the distribution of healthcare services on ischemic stroke fatality. This study aimed to explore the relationship between three ischemic stroke outcomes (incidence, mortality, and fatality) and accessibility to hospitals in Spain, considering its economic development. A cross-sectional ecological study was performed using data on hospital admissions and mortality due to ischemic stroke during 2016-2018. Gross geographic product (GGP) per capita was estimated and a healthcare accessibility index was created. A Besag-York-Mollié autoregressive spatial model was used to estimate the magnitude of association between ischemic stroke outcomes and economic development and healthcare accessibility. GGP per capita showed a geographical gradient from southwest to northeast in Spain. Mortality and case-fatality rates due to ischemic stroke were higher in the south of the country in both women and men aged 60+ years. In women and men aged 20-59 years a EUR 1,000 increase in GGP per capita was associated with decreases in mortality of 5% and 4%, respectively. Fatality decreased 3-4% with each EUR 1,000 increase of GGP per capita in both sexes and in the 20-59 and 60+ age groups. Decreased healthcare accessibility was associated with higher fatality in the population aged 60+. Economic development in southwest Spain would not only improve employment opportunities but also reduce ischemic stroke mortality. New health related strategies to improve hospital accessibility should be considered in more sparsely populated regions or those with worse transport and/or healthcare infrastructure.
[Effectiveness of the Adequate Childbirth Program in reducing cesarean section rates in private maternity hospitals in São Paulo , Brazil]
Cesarean section is a life-saving intervention, but its use without obstetric indication leads to short- and long-term complications. Brazil is internationally known for its high cesarean rates, especially in the private sector. To reverse this problem, the Brazilian National Regulatory for Private Health Insurance and Plans launched the Adequate Childbirth Program, and this retrospective study aims to analyze its effectiveness. We included the total of births performed in private maternity hospitals between 2014 and 2019 registered on the Brazilian Information System on Live Births (SINASC) database to compare the evolution of cesarean section rates in hospitals participating and not participating in the project. A total of 277,747 births were analyzed, showing a reduction in the cesarean section rate in both groups but more pronounced among the participant institutions. No reduction in cesarean performance was observed before the program launch (2014), but there was a constant downward trend after 2014, until it became significant in 2018. This result occurred independently of demographic, maternal, and Robson group variables. The cesarean section rate of hospitals participating in the program went from 83.8% to 72.3% (95% confidence interval - 95%CI: 71.7-72.9). Despite the reduction, it remains well above the expected rates according to the c-model tool, which would be 45.2% (95%CI: 33.9-56.5) for this population. Results showed that a well-conducted public policy together with private institutions can change the scenario of labor and birth care, reducing high cesarean section rates.
[Organizational roles, work-family conflict, job satisfaction, and mental health of teachers regarding affective organizational commitment]
To examine multiple relations between organizational roles, work-family conflict, job satisfaction, mental health, and affective organizational commitment among basic education teachers, a cross-sectional study was conducted with a sample of 438 respondents, to whom the Scale for the Assessment of Psychosocial Stressors in the Workplace (EAEPCL, acronym in Portuguese), the General Job Satisfaction Scale, the General Health Questionnaire (GHQ-12) and the Reduced Affective Organizational Commitment Scale (ECOA, acronym in Portuguese) were applied. Data were analyzed by structural equation modeling and the estimated measurement model indicated convergent and discriminant validity, as well as reliability regarding the latent variables used. Direct effects of conflict and role ambiguity on job satisfaction, common mental disorders (CMD) and affective organizational commitment were observed, as well as indirect effects on the latter two mediated by job satisfaction. As for role overload, its direct effects occurred only in relation to job satisfaction, the latter mediating the effect of the former on CMD and affective commitment, whereas work-family conflict mediated the effect of role overload on CMD. These results highlight the harmful effects of role stressors and job (dis)satisfaction on the mental health of teachers by making them more vulnerable to developing CMD and indicate how these can affect results of interest to the institutions studied, such as affective commitment in school organizations.
[Effect of previous exposure to COVID-19, occurrence of spikes, and type of vaccine on the humoral immune response of institutionalized older adults]
This study evaluated the explanatory factors of humoral immune response in older adults admitted to long-term care institutions in Buenos Aires, Argentina, up to 180 days after vaccination. An open-label, prospective, multicenter cohort study was conducted with volunteers who received two doses of the Sputnik V, Sinopharm, or AZD1222 vaccines. Plasma samples were analyzed at 0 and 21 days after the first dose, 21 days after the second dose, and 120 and 180 days after the first dose. Marginal linear models and generalized additives mixed models were adjusted to determine the behavior of anti-spike IgG antibody concentration over time according to exposure group (naïve/no-naïve) and vaccine. Occurrence of an outbreak of COVID-19 in long-term care institutions and comorbidities were the covariates analyzed. A total of 773 participants were included, with a mean age of 83 years (IQR: 76-89). Results showed that antibody levels in the naïve: Sinopharm group were significantly lower to the other groups (p < 0.05). Antibody levels in the no-naïve: Sinopharm group were similar to those in the naïve group who received AZD1222 (p = 0.945) or Sputnik V (p = 1). Participants exposed to outbreaks in long-term care institutions had significantly higher antibody levels, regardless of exposure group and vaccine (p < 0.001). In conclusion, previous exposure to COVID-19, type of vaccine, and admittance into a long-term care institution with a history of outbreaks are factors to be considered in future epidemic events with transmission dynamics and immunological mechanisms similar to COVID-19, in populations similar to the one analyzed.
[Intersectoral actions and the recognition of a source of primary care for Brazilian adolescents]
This study aimed to analyze the association between the development of intersectoral actions between school/primary health care (PHC) services and the recognition of a usual source of care of PHC among Brazilian adolescents. This is a cross-sectional study, from the Brazilian National Survey of School Health (2015) conducted with a complex sampling of 97,903 adolescents. The association between intersectoral actions between PHC services and schools and the recognition of a usual source of care of PHC were estimated by the prevalence ratio (PR), using the logistic regression model and considering the sample weight factor with Stata 14.0 Of the analyzed adolescents, 72.8% of them studied in schools that developed intersectoral actions with PHC services. Among adolescent students from schools that developed intersectoral actions, an association was observed between the recognition of usual source of care of PHC and intersectoral actions (PR = 1.11; 95%CI: 1.08-1.14). When analyzed for actions of the School Health Program (PR = 1.40; 95%CI: 1.37-1.43), and the development of actions between the school and PHC services (PR = 1.08; 95%CI: 1.05-1.12). The results show that there is a positive association between the recognition of PHC services as a usual source of care and intersectoral actions. However, from the perspective of an intersectoral practice, there are challenges in the articulation between health and education sectors for implementing prevention and promoting adolescent health in school. They involve greater knowledge about the adolescents' perception of the quality of the service offered by health units.
[The symbolic value of drug use for ill-housed people: drug that kills and nourishes]
Drugs have been consumed since ancient times, and their taboo has generated segregation and hindered the proper confrontation of harmful use. This study investigated the real and symbolic values of drug use for ill-housed people beyond pathologization, seeking to understand factors that hinder giving them up, even with intense losses and suffering. It also aimed to understand its implications for health care. This is a phenomenological qualitative research based on participant observation of ill-housed people care provided by the Street Clinic, interviews with ill-housed people and focus group with professionals from the Health Care Network in Rio de Janeiro city, Brazil, between March 2017 and July 2019. Results showed that "drug use" interacted with the research categories as follows: drugs are the main reason for living and staying on the streets; drugs motivate having financial activity; drugs cause abandonment of health treatment; drugs soothe and cause depression, suffering and hunger; drugs make them seek shelter and religion to "escape" using, but without adequate treatment hope leads to relapse and low self-esteem - which one want to get rid of, but few successes undermine hope. As expected, it is the reason for divergences among professionals regarding the type of care and support for ill-housed people. Given the results, how can we face abusive use that relieves hunger, loneliness, suffering and depression? How to take care of a use that generates hunger, depression, affective, health and self-esteem losses? A cyclical story told by people in situations of extreme vulnerability. Unveiling the symbolic plurality of drug use enables reflections and new ways of caring for ill-housed people.
Pathways of physical activity behavior after an intervention with students from vulnerable areas: a cluster randomized controlled trial based on a socioecological approach
Efforts are needed to better understand what are the effective pathways that can optimize success in school-based physical activity interventions. This study aimed to investigate the mediators of a school-based intervention in the practice of physical activity in Brazilian students. The Fortaleça sua Saúde [Strengthen Your Health] program followed 1,085 students (11-18 years) over a semester. This multi-component intervention included training teachers, offering physical activity opportunities, and health education. Self-reported moderate-to-vigorous physical activity and potential mediators (attitude, self-efficacy, social support, perceived neighborhood environment, and physical activity facilities at school) were assessed. The product of coefficient analysis was performed. The sample was composed of 1,085 students (51.5% boys). The total effect of the intervention was 0.706 (95%CI: 0.276; 1.136). A total of 40% of the intervention effect on moderate-to-vigorous physical activity was explained by attitude towards physical activity and social support from friends and teachers. Social support from friends was a significant mediator only among boys (ab: 0.113, 95%CI: 0.027; 0.256), and social support from teachers only among girls (ab: 0.135, 95%CI: 0.019; 0.328); indicating a statistically significant indirect effect of the program on moderate-to-vigorous physical activity via these mediators. A relevant part of the effect of a multicomponent intervention on physical activity among students from vulnerable areas is explained by changes via variables at different levels of the socioecological model, including social support from friends and teachers, and attitude towards physical activity. These results should be considered in public policies.
[Analysis of the performance of public and private hospitals serving the Brazilian Unified National Health System]
This article aims to analyze the performance of the Brazilian Unified National Health System (SUS, acronym in Portuguese) hospital network based on the national databases of the Brazilian Hospital Information System (SIH, acronym in Portuguese) and the Brazilian National Registry of Health Establishments (CNES, acronym in Portuguese). The research used a set of indicators covering the production of admissions, the profile, quality and performance of care, associated with hospital size and legal nature. For data analysis, the Analysis of Variance with Tukey-Kramer test was used to highlight the differences between public and private hospitals, the moderation analysis to verify the effect of hospital size and the Pabon Lasso model to integrate the results. The results show that the increase in the number of beds influences the performance of the indicators differently for public and private hospitals. Public hospitals showed higher gains in scale efficiency with the increase in beds, whereas private non-profit hospitals showed a higher performance in the set of indicators and a more balanced performance in the different sizes. The application of the Pabon Lasso model showed that small hospitals, both public and private, perform poorly. It also showed that from medium-sized onwards, public and private hospitals perform well. However, each category displays particularities in its performance profile, reflecting a diversity of practices and operational results. This study thus confirms previous findings that hospital performance tends to improve as the number of beds increases, but also reveals that it varies significantly depending on the legal nature of these institutions.
[Catastrophic expenditure in children with visual impairment: a cross-sectional study with caregivers in Rio de Janeiro, Brazil]
Caring for a visually impaired child can affect the caregiver's income and, in turn, the family's. Catastrophic spending resulting from increased expenses and reduced income must be taken into account, whether due to unemployment, a reduction in the number of hours worked or the difficulty of entering or reentering the job market. Given this scenario, the main objective of this study was to estimate the catastrophic spending attributed to the caregiver of blind or low-vision children in reference centers for education for the blind, ophthalmology and child health located in the city of Rio de Janeiro, Brazil, identifying which factors are associated with a higher or lower prevalence of this expenditure. It was found that 53.3% of care for blind children involved 40% or more of their income. Among the caregivers of children with low vision, catastrophic spending is milder, compromising at least 40% of income for 36.8% of the caregivers. The factors associated with a higher prevalence of catastrophic spending were the caregiver's age, the number of residents in the household, higher schooling, lower household income, renovations to the home, health insurance, taking out loans, selling assets, the number of health units where the child receives treatment and the relationship of the main caregiver. The burden placed on caregivers of visually impaired children indicates a situation of vulnerability that shows the need for access to financial and social protection mechanisms, through policies that are capable of serving this group.
[Male vulnerabilities and stereotypes in the social representations of prostate cancer]
In society, cancer is commonly associated with an incurable and disabling disease that causes damage beyond the biological scope, impacting the psychological and sociocultural dimensions of cancer patients. From a cultural point of view, men construct narratives about prostate cancer based on their experiences and social contexts, expressing moral, ethical, and sociopolitical elements attributed to the cause of this type of cancer. We sought to understand the causes of prostate cancer as represented by men living with this type of cancer and its repercussions on self-care. A descriptive, qualitative study based on the Theory of Social Representations was conducted with 31 men diagnosed with prostate cancer treated at a High Complexity Oncology Unit. Data were collected from April to June 2022 by in-depth, individual, and semi-structured interviews. The corpus was inserted into the ALCESTE software. Alcohol intake, smoking, sexual promiscuity, and not taking care of oneself were the main behaviors understood as causes of cancer, which generates self-responsibility and guilt for the illness. Social representations of these causes, translated into behaviors not aligned with what social morality dictates as right, have repercussions on the moralizing notion of cancer as punishment, in which the disease expresses the patient's character, anchored in the Judeo-Christian religious discourse, which reduces the sociopolitical burden of male vulnerabilities and reinforces stereotypes from patriarchal society.
[Impact of telediagnostics on hospitalizations due to cardiovascular diseases: an approach in municipalities of Bahia State, Brazil]
Hospitalization costs due to cardiovascular diseases are high. In 2019, for Bahia State, Brazil, alone, they exceeded BRL 153 million for the Brazilian Unified National Health System, surpassing the costs of cancer hospitalizations. This fact will show an upward trend with the increase in life expectancy in Brazil (7.3 years more by 2060). Introducing new technologies can mitigate the problem. This study analyzes the impact of telediagnostics in electrocardiogram on hospitalizations for cardiovascular diseases in 326 municipalities in Bahia from 2014 to 2020. Diff-in-diff estimator method was used for analysis of the periods before and after the implementation of telediagnostics in Bahia. Results show that the municipalities which introduced the new technology reduced cardiovascular diseases hospitalizations by 6 for each additional year. In the case of families benefiting from the Brazilian Income Transfer Program, the reduction was 3.26 hospitalizations, and 3.08 among municipalities with the specialized service. Hospitalization increase by 7.66 in the 30 to 59 age group and by 5.34 among men for each additional year. Results show a reduction of 1.15 hospitalizations for rheumatologic heart diseases and 1.39 among diabetic people. In terms of ethnicity/color, underreporting was identified in the conditions studied, resulting in more severe prognoses for blacks. Telediagnostics was effective in reducing this inequality by expanding access and reducing hospitalizations, playing a crucial role in public health and impacting mortality reduction. The theme, therefore, deserves further studies with different samples and sample periods.
[Food consumption of the urban population in a municipality in the Legal Amazon, during climate events of flood and drought: a comparative study]
The aim of this study was to compare the food consumption of the population of Coari, Amazonas State, Brazil, according to the NOVA Classification, during the hydrological phases of drought and flooding of the Amazon rivers. An epidemiological, population-based, cross-sectional study was carried out. The sample consisted of 457 adult individuals. Data were collected in two stages using a sociodemographic instrument, a 24-hour food recall and a food frequency questionnaire adapted to local habits. The data were analyzed using the statistical program R version 4.2.4, using Pearson's chi-square, Fischer's exact and Bhapkar's tests. The sample was predominantly female (drought = 70%/flood = 71.2%) and brown (drought = 65.4%/flood = 66.2%). Most of the interviewees ate meals (breakfast, lunch and dinner). Afternoon snacks were the most common intermediate meal, especially during flooding (274/70.2%). In natura or minimally processed foods predominated at the three main meals (95%). Ultra-processed foods were consumed little or not at all and were mentioned especially during the drought (152/33.3%; p = 0.007). On the other hand, consumption of regional foods (tucumã, beiju, tapioca flour and açaí) increased during the flood (p < 0.001). Consumption of in natura or minimally processed foods continues to be the mainstay of the diet in the interior of Amazonas, with a predominance of regional foods during the flood and processed and ultra-processed foods during the drought, demonstrating the influence, albeit subtle, of the hydrological phases on the food consumption of this population.
[Descriptive study of events allegedly attributable to mpox vaccination in Brazil in 2023]
This study describes the surveillance and safety actions of the mpox (Jynneos) vaccine in Brazil, from 2022 to 2023. A descriptive study of mpox cases and events supposedly attributable to vaccination and/or immunization for Jynneos vaccine, recorded in the information systems, was conducted. Absolute and relative frequencies and reporting coefficients of events supposedly attributable to vaccination and/or immunization per 1,000 administered doses were calculated. A total of 9,596 cases of mpox were registered and 49,000 doses of vaccine were distributed, of which 14,395 (31%) were administered and 65 events supposedly attributable to vaccination and/or immunization (4.5 per 1,000 administered doses) were notified. All events supposedly attributable to vaccination and/or immunization were non-serious, and 22 (33.8%) cases had product-related reactions. Results are within the expected frequency; however, the number of administered doses may not have been sufficient to detect rare or unusual events. Continued surveillance is necessary to ensure vaccination effectiveness and safety, especially among groups at higher risk for the disease.
[Sex workers in the Brazilian pandemic: effects on and relations with health]
This paper describes the results of the study I Want More! The Lives of Sex Workers During the COVID-19 Pandemic, which is part of the EPIC community research program. The study analyzed the effects of the pandemic on the lives of cis, trans and travesti sex workers in nine Brazilian states and 11 cities throughout 2020 and 2021. This article focuses on the qualitative component of the study, which was based on semi-structured, remote and face-to-face interviews carried out with 43 sex workers, and its comparison with the quantitative component. The effects are analyzed in relation to the Brazilian pandemic framework, considering the social, economic and political dimensions of the COVID-19 virus. Some of the key themes of the analysis are cases of illness, specific social isolation practices, prevention and care management practices, individual vaccination and collective vaccination strategies. We also share the daily and activist responses drawn up by sex workers in a political agenda that opposes the individualistic, familialist, domestic, and neoliberal logic of isolation by adopting community care perspectives, which was the only line of health action for this work category during the pandemic. Collective actions reposition sex work at the interface between public health and human rights and take as their principle the "street knowledge", from activism, and the workers' power of decision over their own bodies.
On the margins of suicide: everyday horizons, turning points and trajectories of protection in peripheral young women
Suicidal behavior and non-suicidal self-harm in vulnerable groups and population minorities pose a challenge for suicidology, complicating the universality of suicide. The goal of this paper is to analyze the lives of young women from marginalized communities, considering their experiences with suicidality and their relational and violent horizons. Nine women who took part in the fifth wave of a cohort on mental health and violence (2005-2022) in São Gonçalo, Rio de Janeiro State, Brazil, were interviewed (2022) about the contexts that kept them from committing suicide despite significant emotional distress from childhood through youth. From theme-based content analysis, three categories stood out and may contribute to an intersectional, decolonial and socially relevant approach to preventing self-destructive behavior. In the first, views on self-inflicted violence, better explained by the cores concepts of "sin" and "illness" than by the general violence they experienced. In the second, indirect references to self-harm behavior, where it was recognized that the use of euphemisms reflects not only the taboo but also the silencing of and discrimination against minorities. In the third, layers of protection and turning points, where "spirituality", "occupation" and "motherhood" were interpreted as the main associations between factors of protection and resilience in the trajectories and daily lives of these young women. A closer look that acknowledges the humanity, rights and psychological distress of groups subjected to violence and discrimination not only enhances care and prevention of suicidal behavior but also deepens understanding of this human and universal phenomenon.
Biotechnological sovereignty is not a mere nationalist concept, it is a necessity for Colombia and Latin America
During the pandemic, Latin American countries suffered the collapse of their health systems. This was caused by the high demand for care of patients infected with SARS-CoV-2, which was added to the care of patients with other diseases. The significant increase in demand for health services caused medical and laboratory supplies to decline rapidly. The COVID-19 pandemic exacerbated a health crisis in several developing countries, mainly caused by insufficient systematic policies for integrating scientific knowledge. The current Colombian government must formulate a Biotechnological or Biosecurity Sovereignty Law that guarantees scientific autonomy, ensuring that Colombia is self-sufficient in Science, Technology, and Innovation. Colombian government should also focus on establishing and developing pharmaceutical chemical production by acquiring active chemical ingredients from other countries. This strategy could reduce the production costs and final prices of medicines, as well as generate high-level employment and wealth for the country. In this way, the Colombian government could prevent shortage of essential medicines and excessive price increases by commercial intermediation. In conclusion, the manuscript focuses on the lack of biotechnological sovereignty in Colombia. We propose a model of a Latin American Science and Technology ecosystem to achieve biotechnological sovereignty via state funding of research, strengthening universities, and fostering participation among private companies and Ministries of Science, Education, Trade, and Health. Scientific autonomy based on innovative processes that strengthen biotechnological independence can contribute to the economy by generating gross added value, creating high-quality employment, and facilitating the appropriation and social dissemination of knowledge, and cost reduction.
[Intersectorality in the São Paulo Policy for the Prevention of Violent Deaths of Children and Adolescents: an analysis of Law n. 17,652/2023]
This study aims to identify and analyze the obstacles to intersectorality in the São Paulo Policy for the Prevention of Violent Deaths of Children and Adolescents in the State of São Paulo, Brazil, established by Law n. 17,652/2023, within the scope of the actions of the São Paulo Committee for the Prevention of Homicide in Adolescence. This is a qualitative study using the case study technique based on: interviews, participant observation, field diary and document analysis. The results showed that obstacles to the implementation of intersectorality in this Law exist, given the sectorization present both in Bill n. 382/2022, which originated it, and the vetoes in its final version, enacted by the government in March 2023. Intersectoral policies must have instruments to guarantee the articulation of sectors, clearly defining the responsibilities of those involved. In addition, it is of fundamental importance to recognize the limits of the powers attributed to the legislature when proposing laws that aim to establish them.