Next-generation sequencing (NGS) has been offered as a large-scale and effective genomic analyzing tool. In this research, we seek to examine the possible benefits of an actionable mutation panel in association with clinical and pathological features in the treatment of esophageal cancer.

Type 1 diabetes mellitus (DM1) and obesity represent two chronic pediatric diseases characterized by increased risk for renal impairment and cardiovascular disease. The potential usefulness of neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9), two novel biomarkers, for predicting early kidney injury or increased cardiovascular risk in children and adolescents with DM1 or obesity, was investigated in this cross-sectional study.

Solanum sisymbriifolium Lam. is a native perennial plant with chemical characteristics of therapeutic importance. In Paraguayan traditional medicine, it is attributed to antihypertensive and diuretic activities. For this reason, the objective of the study was to evaluate the effect of acute oral administration of the ethanolic extract and fraction enriched in saponins obtained from the root of S. sisymbriifolium on the diuresis profile of rats.

This study aimed to investigate the effect of psoralidin, a natural phenolic coumarin compound, on MK-801-induced neurotoxicity that may cause Alzheimer's disease and to determine the phosphodiesterase (PDE)-related molecular mechanism of action.

COVID-19, first identified in December 2019, quickly became a global pandemic and remains a significant public health concern. Robust data is rare, especially in pregnant women. The symptoms of this disease range from mild to severe respiratory distress syndrome and mortality. The present study aimed to evaluate the factors influencing COVID-19 severity in women to be better prepared in case of a new epidemic.

The Editor in Chief and the Publisher are issuing an expression of concern to alert readers that the following article is under investigation due to a potential ethical breach regarding lack of transparency in the transplantation procedure as outlined in the article published by Rogers W et al (DOI: 10.1136/bmjopen-2018-024473): - Chen J, Zhong L. Clinical significance of serum hepcidin-25 levels in predicting invasive fungal disease in patients after transplantation. Eur Rev Med Pharmacol Sci 2013; 17 (13): 1769-1773-PMID: 23852902. Further updates will be provided once the investigation is completed. The authors have been notified about the ongoing investigation and the publication of this expression of concern.

The recently discovered protein adropin is a highly conserved polypeptide that plays critical functions in energy homeostasis, metabolic processes, fat metabolism, and insulin resistance. On the other hand, non-alcoholic fatty liver disease (NAFLD) is a medical condition that causes the buildup of fat in the liver cells in individuals who consume little or no alcohol. The frequency of NAFLD is rising globally, and it is frequently linked to obesity, insulin resistance, type 2 diabetes, and metabolic syndrome. Therefore, this study evaluates the association between adropin levels and insulin resistance in individuals with and without NAFLD.

Standard treatment for adults with acute myeloid leukemia (AML) involves anthracycline and cytarabine, while alternative regimens are necessary for elderly and frail patients. This study aims to compare the effectiveness and safety of various induction regimens in AML patients.

The article "MiR-299-3p inhibits proliferation and invasion of cervical cancer cell via targeting TCF4" by Y. Yu, J.-D. Zhao, H. Yang published in Eur Rev Med Pharmacol Sci 2019; 23 (13): 5621-5627-DOI: 10.26355/eurrev_201907_18296-PMID: 31298314 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/4275612B2FA-7C9A9CD7255B791D3A6), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation revealed data fabrication and several figure manipulations. Specifically, duplications were found within Figures 2C, 2F, 3C, 4A, and 4E. Moreover, Figure 2 (C, D, E), Figure 3C, and Figure 4 (C-D) contained duplications from previously published articles. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. Consequently, the Editor in Chief decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/18296.

The article "Aldose reductase inhibitor Epalrestat alleviates high glucose-induced cardiomyocyte apoptosis via ROS" by X. Wang, F. Yu, W.-Q. Zheng, published in Eur Rev Med Pharmacol Sci 2019; 23 (3 Suppl): 294-303-DOI: 10.26355/eurrev_201908_18660-PMID: 31389594 has been retracted by the Editor in Chief. The authors contacted the journal in June 2024, requesting to withdraw the article. Following this request, the journal discovered that the article was commented on PubPeer (link: https://pubpeer.com/publications/DE4E22B2B9E506EDC2E650C58152E0). The journal started an investigation and asked the authors to provide answers to the concerns raised as well as to send the raw data. Following the journal's requests, the authors neither responded nor provided the raw data. The journal's investigation revealed duplications between panels Blank, HG+1 umol/l, and HG+10 umol/l of Figure 4A. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/18660.

This study aimed to evaluate the association between tumor necrosis factor-α inhibitor (TNFi) therapy and cardiovascular (CV) outcomes, as well as all-cause mortality, in patients with ankylosing spondylitis (AS).

Anaplastic thyroid carcinoma (ATC) is an endocrine tumor with low incidence and one of the most aggressive human malignancies. The median survival is only 3-10 months, and the optimal therapeutic approach as well as prognostic factors have not been established. The aim of this study was to evaluate the long-term survival and good prognostic factors of patients with ATC.

The aim of the study was to determine the expression pattern of long pentraxin 3 (PTX3) mRNA in cumulus cells (CCs) isolated from metaphase II oocytes of women with unilateral endometrioma undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRHa) protocol.

Ectopic pregnancy (EP) is a serious obstetric condition that can be life-threatening, with various risk factors contributing to its development. In particular, in vitro fertilization (IVF) techniques may lead to an increased rate EP. Additionally, also endometriosis seems to be related to this particular obstetrical condition.

Endovascular interventions (EVIs) are an effective and minimally invasive therapeutic option for peripheral arterial diseases (PADs). This study aimed to evaluate the results of EVIs for PADs on the targeted arterial segments (TASs).

The objectives of this study were to characterize the endotypes of different chronic rhinosinusitis without nasal polyps (CRSsNP) samples, to investigate the effects of certain anti-inflammatory drugs on these endotypes, and to investigate the effect of the same drugs on recently identified CRSsNP marker proteins.

The article "MicroRNA-613 attenuates the proliferation, migration and invasion of Wilms' tumor via targeting FRS2" by H.-F. Wang, Y.-Y. Zhang, H.-W. Zhuang, M. Xu, published in Eur Rev Med Pharmacol Sci 2017; 21 (15): 3360-3369 - PMID: 28829507 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/19E8759FF9D86F9AB839B4FCE08C62), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation identified numerous duplications within Figure 2, as well as duplications between Figure 2 and figures from previously published articles (https://doi.org/10.1111/cas.12656, https://doi.org/10.1016/j.biochi.2019.03.011). Duplications were also found within Figure 3 and between Figure 3 and previously published articles (doi: 10.12659/msm.921288, doi: 10.12659/msm.903462). Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/13201.

The article "The inhibitory effect of miR-375 targeting sp1 in colorectal cancer cell proliferation" by X.-H. Liu, J. Wang, Y.-H. Dong, published in Eur Rev Med Pharmacol Sci 2018; 22 (2): 405-411 - PMID: 29424897 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/DF4072237DD0F624A7AE9B34B4EB6D), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. Initially, the authors asked to retract this manuscript, but were not available for further comments during the investigation; therefore, raw data were not provided. The journal's investigation revealed Figure duplication within Figure 1 and between Figure 1 and Figure 2. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14188.

Molecular docking studies were conducted to assess the binding affinities of five potential inhibitor candidates [PDB (Protein Data Bank) ID: 6L6E] against Phosphodiesterase 5 (PDE5), with Sildenafil used as the reference compound. The aim of this study is to reveal the potential inhibitory role of plant-derived compounds compared to Sildenafil, a PDE5 inhibitor.

The advancement of telecommunication technology and devices promptly transformed mobile phones into indispensable objects in our day-to-day lives, but their biological effects remain unclear. Therefore, this study aimed to investigate the potential histopathological changes induced by mobile phone radiation in the parotid gland and the nearby tissues.

Correction to: Eur Rev Med Pharmacol Sci 2021; 25 (18): 5801-5806-DOI: 10.26355/eurrev_202109_26798-PMID: 34604971 published online on September 30, 2021. The methodology section of this research article incorrectly stated that the lexi-interact checker program is freely accessible. The study was conducted at Uludağ University using university-access computers. As a result, the lexi-interact program, provided through UpToDate and accessed via the university's subscription service, was mistakenly described as a free resource. Therefore, the sentence "pDDIs, defined using the lexi-interact (a free online interaction checker, provided from UpToDate, 2020, https://www.uptodate.com/drug-interactions), were classified based on the significance of the interaction level (minor, moderate, major)" has been corrected as follows: - pDDIs, defined using the lexi-interact (an online interaction checker, provided from UpToDate, 2020, https://www.uptodate.com/drug-interactions), were classified based on the significance of the interaction level (minor, moderate, major). There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/26798.