RESUSCITATION

The gap between promise and reality: Evaluating new AI's role in CPR education
Semeraro F, Fijačko N, Gamberini L, Bignami EG and Greif R
Amiodarone dose in patients with shockable out-of-hospital cardiac arrest
Gelbenegger G, Cheskes S, Jilma B, Zeitlinger M, Lin S, Drennan IR and Jorda A
Amiodarone is used in shockable out-of-hospital cardiac arrest (OHCA), but the ideal dose is unknown.
Diastolic blood pressures and end tidal carbon dioxides during cardiopulmonary resuscitations and their association with outcomes in adult out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the Augmented Medication CardioPulmonary Resuscitation (AMCPR) trial
Kim JS, Kim YJ, Hong SI, Kim SM, Chae B, Ryoo SM and Kim WY
The optimal targets for diastolic blood pressure (DBP) and end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR) and their association with outcomes remain unclear. This study aimed to evaluate the association between DBP and ETCO2 and the return of spontaneous circulation (ROSC) during CPR.
Revisiting Priorities in Resuscitative Hysterotomy
Wolff J and Dahmen J
Evaluation of interventions in prehospital and in-hospital settings and outcomes for out-of-hospital cardiac arrest patients meeting the termination of resuscitation rule in Japan: A nationwide database study (The JAAM-OHCA Registry)
Shiozumi T, Matsuyama T, Nishioka N, Kiguchi T, Kitamura T, Ohta B and Iwami T
Out-of-hospital cardiac arrest (OHCA) is a global health burden with low survival rates. The termination of resuscitation (TOR) rule, widely adopted internationally, aims to preserve dignity, optimize resources, and protect healthcare providers. However, prehospital TOR is not implemented in Japan, presenting legal and practical challenges. This study analyzes temporal trends in prehospital and in-hospital interventions for OHCA patients with poor predicted outcomes.
The impact of alternate defibrillation strategies on time in ventricular fibrillation
Cheskes S, Drennan IR, Turner L, Pandit SV, Walker RG and Dorian P
Time in ventricular fibrillation (VF) is associated with survival after out-of-hospital cardiac arrest (OHCA). The impact of vector change defibrillation (VC) and double sequential external defibrillation (DSED) on VF duration has not been explored.
Use of Machine Learning Models to Identify National Institutes of Health-Funded Cardiac Arrest Research
Coute RA, Soundararajan K, Kurz MC, Melvin RL and Godwin RC
To compare the performance of three artificial intelligence (AI) classification strategies against manually classified National Institutes of Health (NIH) cardiac arrest (CA) grants, with the goal of developing a publicly available tool to track CA research funding in the United States.
Temporal Dynamics of Neural Synchrony and Complexity of Auditory EEG Responses in Post-Hypoxic Ischemic Coma
Alnes SL, Aellen FM, Rusterholz T, Pelentritou A, Hänggi M, Rossetti AO, Zubler F, Lucia M and Tzovara A
The capacity to integrate information across brain regions and sufficient diversity of neural activity is necessary for consciousness. In patients in a post-hypoxic ischemic coma, the integrity of the auditory processing network is indicative of chances of regaining consciousness. However, our understanding of how measures of integration and differentiation of auditory responses manifest across time of coma is limited. We investigated the temporal evolution of neural synchrony of auditory-evoked electroencephalographic (EEG) responses, measured via their phase-locking value (PLV), and of their neural complexity in unconscious post-hypoxic ischemic comatose patients. Our results show that the PLV was predictive of chances to regain consciousness within the first 40 hours post-cardiac arrest, while its predictive value diminished over subsequent time after coma onset. This was due to changing trajectories of PLV over time of coma for non-survivors, while survivors had stable PLV. The complexity of EEG responses was not different between patients who regained consciousness and those who did not, but it significantly diminished over time of coma, irrespective of the patient's outcome. Our findings provide novel insights on the optimal temporal window for assessing auditory functions in post-hypoxic ischemic coma. They are of particular importance for guiding the implementation of quantitative techniques for prognostication and contribute to an evolving understanding of neural functions within the acute comatose state.
Reply to "Revisiting Priorities in Resuscitative Hysterotomy"
Leech C, Nutbeam T, Couper K and Yeung J
Intraventricular Pressure and Volume during Conventional and Automated Head-up CPR
Pourzand P, Moore J, Metzger A, Suresh M, Salverda B, Hai H, Duval S, Bachista K, Debaty G and Lurie K
Active compression-decompression (ACD) CPR, an impedance threshold device (ITD) and automated head and thorax elevation, collectively termed AHUP-CPR, increases cerebral and coronary perfusion pressures, brain blood flow, end-tidal CO2 (ETCO2) and cerebral oximetry (rSO2) in animal models compared with conventional (C) CPR. We tested the hypothesis that cardiac stroke volume (SV) is higher with AHUP-CPR versus C-CPR or ACD+ITD in a porcine cardiac arrest model.
Cardiac arrest survivors' self-reported cognitive function, and its association with self-reported health status, psychological distress, and life satisfaction-a Swedish nationwide registry study
Larsson K, Hjelm C, Strömberg A, Israelsson J, Bremer A, Agerström J, Carlsson N, Tsoukala D, Nordström EB and Årestedt K
Self-reported cognitive function has been described as an important complement to performance-based measurements but has seldom been investigated in cardiac arrest (CA) survivors. Therefore, the aim was to describe self-reported cognitive function and its association with health status, psychological distress, and life satisfaction.
Cost-Effectiveness of Drone-Delivered Automated External Defibrillators for Cardiac Arrest
Maaz M, Benjamin Leung KH, Boutilier JJ, Suen SC, Dorian P, Morrison LJ, Scales DC, Cheskes S and Chan TCY
Out-of-hospital cardiac arrest (OHCA) is a significant cause of mortality and morbidity in North America, for which timely defibrillation of shockable rhythms is essential. Drones have been proposed as an intervention to improve response time and are being implemented in practice.
Women are profoundly underrepresented in educational depictions of bystander cardiopulmonary resuscitation
Purkarthofer D, Bachner V, Schlacher F and Orlob S
Descriptive dataset analysis of a Survey on Currently applied Interventions in Neonatal resuscitation (SCIN)
Eckart F, Kaufmann M, Mense L, Rüdiger M and
Each year, millions of neonates require supportive interventions in the delivery room (DR) during the transition from intrauterine to extrauterine life. Resuscitation guidelines are critical for healthcare providers managing these neonates and rely on current evidence of real-world DR management. However, data on the actual frequency of various supportive interventions are often limited, focused on single centers or outdated. This study aims to describe the current practice of neonatal resuscitation and support in the DR and to provide evidence for the development of clinical guidelines.
Semi-autonomous drone delivering automated external defibrillators for real out-of-hospital cardiac arrest: A Danish feasibility study
Jakobsen LK, Bang Gram JK, Grabmayr AJ, Højen A, Hansen CM, Rostgaard-Knudsen M, Claesson A and Folke F
To assess the feasibility and safety of drone-delivered automated external defibrillators (AEDs) in real out-of-hospital cardiac arrests (OHCAs) in Denmark, addressing the critical need for timely defibrillation in OHCAs.
Mitochondrial transplantation improves outcomes after cardiac arrest and resuscitation in mice
Aoki T, Endo Y, Yin T, Kazmi JS, Kuschner CE, Hagiwara J, Ito-Hagiwara K, Nakamura E, Becker LB and Hayashida K
Mitochondrial transplantation (MTx) is an emerging strategy for restoring cellular bioenergetics and mitigating ischemia-reperfusion (IR) injury. We previously demonstrated that MTx improved neurological outcomes and survival in a rat model of cardiac arrest (CA). However, the mechanisms underlying these benefits, particularly regarding immune modulation and transcriptional regulation, remain unclear.
Progress and challenges in implementing "Kids Save Lives" across Europe in 2025
Semeraro F, Thilakasiri K, Schnaubelt S and Böttiger BW
Increasing CPR awareness in Europe through EURO 2024: Lessons from "Get Trained Save Lives"
Lott C, Bahtijarević Z, Klomp P, Verhagen E, Dooren JV and Semeraro F
Artificial Intelligence in cardiopulmonary resuscitation: Driving awareness and debunking myths
Semeraro F, Schnaubelt S, Montomoli J, Bignami EG and Monsieurs KG
There may be more to this than meets the eye: Hospital performance and racial disparities in neurological outcome after out-of-hospital cardiac arrest
Larribau R and Sigaux A
Amiodarone vs Lidocaine in Adult Out-of-Hospital Cardiac Arrest, is there a clear winner?
Overton-Harris P and Lupton JR