Mindfulness-based cognitive therapy (MBCT) has emerged as a promising intervention for generalized anxiety disorder (GAD). This study evaluated MBCT's effectiveness for GAD and examined whether childhood maltreatment moderates its impact.

Chronic loneliness adversely impacts both mental and physical health. As current interventions are only moderately effective, examining vulnerability factors reflected in interpersonal behavior and their relationships with specific chronic loneliness subtypes may provide insights. The present study explored the associations between loneliness vulnerability factors and two subtypes of chronic loneliness: chronic emotional loneliness (a longing for intimate connections) and chronic social loneliness (dissatisfaction with the quantity and quality of one's social network).

Recent work has continued to deepen our understanding of the manifestation of Complex Post Traumatic Stress Disorder (CPTSD). While disturbance of self-organization (DSO) is identified as a key symptom set distinguishing CPTSD from general PTSD diagnostic criteria, specific DSO assessments which include attachment themes would be a helpful tool for clinicians to address DSO in clinical, subclinical, and nonclinical populations. The current research introduces the preliminary validation of the 38-item CPTSD-DSO scale, which has negative self-concept, affect dysregulation, and attachment disruption/interpersonal problem subscales. The sample consisted of 2835 participants collected from online data platforms and an online community sample, with 223 participants indicating a PTSD diagnosis. The scale demonstrated adequate internal consistency alongside strict invariance when comparing males and females as well as across nonclinical and PTSD subgroups. The scale demonstrated expected convergent validity with a brief ACE measure, adult mental health, and a traumatic event checklist. Finally, the scale showed significantly higher scores for the CPTSD subgroup when compared to the general PTSD subgroup. Findings suggest the CPTSD-DSO can be a useful tool for assessing DSO components and opening discussions about self-organization issues in clinical, subclinical, and nonclinical settings.

Attention-deficit hyperactivity disorder (ADHD) may be a risk factor for intra- and inter-parental affective disorders in the perinatal period, placing families at risk for negative outcomes.

Previous studies of brain function alterations that are associated with modified electroconvulsive therapy (MECT) for major depressive disorder (MDD) have yielded conflicting results because of variations in treatment durations, types of antidepressants, and disease course. Consequently, predicting the efficacy of MECT remains challenging. Thirty patients with first-episode, drug-naive adolescent MDD and 34 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging and neuropsychological tests. The patients received MECT and underwent scanning at two time points (baseline and posttreatment). Voxel-mirrored homotopic connectivity (VMHC), support vector machine (SVM), and support vector regression (SVR) analyses were employed to analyze the imaging data. Compared with HCs, patients at baseline exhibited greater VMHC in the cerebellum_2 and cerebellum_8. Following treatment, patients exhibited the restoration of normal VMHC values. Additionally, SVM and receiver operating characteristic curve analyses revealed that VMHC values in the cerebellum_2 could differentiate MDD patients from HCs with 73.85 % accuracy, 70.00 % sensitivity, 79.41 % specificity, and an area under the curve of 0.7486. Furthermore, the SVR results indicated a significant association between predicted and actual symptomatic improvement based on the reduction ratio of Hamilton Depression Rating Scale-17 total scores (R = 0.5269, P < 0.0001). This study provides evidence that MECT modulates homotopic connectivity of the cerebellum_2 in first-episode, drug-naive adolescent MDD. Moreover, VMHC values in the cerebellum_2 may serve as a valuable neuroimaging biomarker for distinguishing MDD from HCs and potentially predicting early treatment response in MDD.

Major depressive disorder (MDD) involves molecular alterations and pathway dysregulation. Metabolic interconnections are crucial for normal functioning, yet current analysis focuses on individual pathways or biomarkers, overlooking intricate metabolic biomarker interactions.

This study aimed to investigate the associations among phenotypic age acceleration (PAA), the prevalence of rheumatoid arthritis (RA), and depression severity and to examine the potential mediating role of PAA in the RA-depression relationship.

This study evaluated adverse events (AEs) associated with Vortioxetine by analyzing extensive data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). We collected data from the FAERS database spanning ten years, from the first quarter of 2014 to the second quarter of 2024, focusing on drug-related AEs involving Vortioxetine. A comprehensive analysis was performed using multiple signal detection methods, including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinker (MGPS). Among 13,116 reports where Vortioxetine was identified as the primary suspect drug, AEs were categorized into 27 system organ classes (SOCs) and 146 preferred terms (PTs). The results highlighted significant signals for common AEs, such as psychiatric disorders, gastrointestinal disorders, and nervous system disorders. Notably, feeling guilty exhibited the strongest signal strength; however, its clinical relevance requires cautious interpretation. Additionally, the study identified novel signals not listed in the drug label but potentially of clinical value, such as hyperarousal and alcoholic, which were significantly associated with Vortioxetine. Of particular note, AEs related to sexual dysfunction were the most diverse, while suicidal ideation was the most frequently reported. The study also uncovered rare but noteworthy signals, including hallucination and olfactory disorders, dermatillomania, and bruxism, which warrant further attention. In conclusion, while Vortioxetine demonstrates multifaceted benefits in alleviating symptoms of depression, its clinical use requires a comprehensive evaluation of potential risks. Developing safe and rational treatment strategies is essential to optimize therapeutic outcomes.

The ability to consider the long-term implications of emotional events is integral to mental health and adaptive psychological functioning. However, it remains unclear whether flexibly synchronizing emotion regulation strategies to the long-term implications of emotional events is associated with adaptive outcomes.

Anhedonia is a core symptom of major depressive disorder (MDD), which has been shown to be associated with abnormalities in cortical morphology. However, the correlation between cortical thickness (CT) changes with anhedonia in MDD and gene expression remains unclear.

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are highly prevalent mental disorders in psychiatry, but their overlapping symptoms often complicate precise diagnoses. This study aims to explore differential brain activation patterns in healthy controls (HC), MDD, and GAD groups through functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT) to enhance the accuracy of clinical diagnoses.

Youth mental health is a public health crisis. Bullying has been associated with adverse mental health outcomes including depression and suicidal ideation. We aimed to update information regarding the associations between bullying and sadness and three suicide-related outcomes, along with the potential moderating effect of physical activity (PA).

Medium-chain triglycerides (MCT) and docosahexaenoic acid (DHA) could affect cognitive function, but their combination effects remain unclear. This randomized, double-blind, placebo-controlled trial aimed to evaluate effects of MCT and DHA supplementation, alone or in combination, on mild cognitive impairment (MCI) patients.

Existing cognitive models for depression propose interactions between cognitive emotion regulation strategies (CERS) and cognitive processes. However, often oversimplify these interactions and do not accommodate the complexity of interactions. We aimed to construct and explore the micro-level properties of a network model that can integrate this complexity of the interactions and explore through computational simulations the differential impact of improvements/deterioration in cognitive flexibility and processing speed in the network.

Loneliness is prevalent currently and could result in increased dementia risks, whereas the associations of prolonged loneliness and its changes with cognitive decline and dementia remain less investigated.

We studied cognitive dysfunction in Major Depressive Disorder (MDD) in a sample of healthy, unmedicated individuals without comorbidities. Additionally, we studied the association of cognitive function with response to selective serotonin reuptake inhibitors (SSRIs). Our sample consisted of 113 adult MDD participants and 88 matched healthy controls (HC). Sixty-nine of the MDD participants completed 8 weeks of SSRI treatment. All participants completed a cognitive battery assessing processing speed, executive function, and learning and memory at baseline. This was repeated at week 8 for MDD participants. MDD "Responders" were defined as having ≥50 % improvement on the Hamilton Depression Rating Scale score at week 8 compared to baseline. At baseline, MDD participants performed significantly worse than HC participants on the Symbol Digit Modalities Test (SDMT) (p < .001), Stroop color naming (p = .005) and color-word naming (p = .047), and Brief Visuospatial Memory Test-Revised (BVMT) total recall (p = .02), delayed recall (p < .001), and percent retention (p = .01). MDD participants improved significantly on 6 of the cognitive assessments over 8 weeks. However, there were no significant baseline differences between Responders and Non-responders. SSRI Response was associated with improvement only in the HVLT total recall (p = .02). Our results suggest: 1) a differentiated pattern of cognitive dysfunction exists in healthy, unmedicated MDD compared to HCs; 2) baseline cognition does not delineate an SSRI-responsive/-nonresponsive subgroup, and 3) SSRI response is not associated with broad cognitive improvement after 8 weeks when compared to Non-responders, emphasizing unmet therapeutic challenges.

The relationship between 25-hydroxyvitamin D [25(OH)D] levels, physical activity (PA), and depression risk remains underexplored. This study examines how combinations of 25(OH)D and PA influence depression.

To date, no study has evaluated the cost-effectiveness of positive psychology interventions (PPI) for people with bipolar disorder (BD). This study evaluates the cost-effectiveness of the multicomponent PPI "Living well with bipolar disorder" for people with BD in the euthymic phase, compared to treatment as usual (TAU) alone.