The discovery of radio pulsars over a half century ago was a seminal moment in astronomy. It demonstrated the existence of neutron stars, gave a powerful observational tool to study them, and has allowed us to probe strong gravity, dense matter, and the interstellar medium. More recently, pulsar surveys have led to the serendipitous discovery of fast radio bursts (FRBs). While FRBs appear similar to the individual pulses from pulsars, their large dispersive delays suggest that they originate from far outside the Milky Way and hence are many orders-of-magnitude more luminous. While most FRBs appear to be one-off, perhaps cataclysmic events, two sources are now known to repeat and thus clearly have a longer lived central engine. Beyond understanding how they are created, there is also the prospect of using FRBs-as with pulsars-to probe the extremes of the Universe as well as the otherwise invisible intervening medium. Such studies will be aided by the high-implied all-sky event rate: there is a detectable FRB roughly once every minute occurring somewhere on the sky. The fact that less than a hundred FRB sources have been discovered in the last decade is largely due to the small fields-of-view of current radio telescopes. A new generation of wide-field instruments is now coming online, however, and these will be capable of detecting multiple FRBs per day. We are thus on the brink of further breakthroughs in the short-duration radio transient phase space, which will be critical for differentiating between the many proposed theories for the origin of FRBs. In this review, we give an observational and theoretical introduction at a level that is accessible to astronomers entering the field.

Understanding the physical mechanisms that control galaxy formation is a fundamental challenge in contemporary astrophysics. Recent advances in the field of astrophysical feedback strongly suggest that cosmic rays (CRs) may be crucially important for our understanding of cosmological galaxy formation and evolution. The appealing features of CRs are their relatively long cooling times and relatively strong dynamical coupling to the gas. In galaxies, CRs can be close to equipartition with the thermal, magnetic, and turbulent energy density in the interstellar medium, and can be dynamically very important in driving large-scale galactic winds. Similarly, CRs may provide a significant contribution to the pressure in the circumgalactic medium. In galaxy clusters, CRs may play a key role in addressing the classic cooling flow problem by facilitating efficient heating of the intracluster medium and preventing excessive star formation. Overall, the underlying physics of CR interactions with plasmas exhibit broad parallels across the entire range of scales characteristic of the interstellar, circumgalactic, and intracluster media. Here we present a review of the state-of-the-art of this field and provide a pedagogical introduction to cosmic ray plasma physics, including the physics of wave-particle interactions, acceleration processes, CR spatial and spectral transport, and important cooling processes. The field is ripe for discovery and will remain the subject of intense theoretical, computational, and observational research over the next decade with profound implications for the interpretation of the observations of stellar and supermassive black hole feedback spanning the entire width of the electromagnetic spectrum and multi-messenger data.