Eczematous cheilitis is a common issue in atopic dermatitis patients, and restoring the lip barrier function is crucial for effective management. Wet wrap dressing is frequently used as an adjuvant method to treat atopic dermatitis lesions, and a similar strategy can be applied to the treatment of atopic cheilitis. This study aimed to evaluate the short-term effects of saline gauze wet dressing on lip barrier function and to compare the clinical efficacy of gauze wet dressing as an adjuvant treatment for eczematous cheilitis. The study involved patients with eczematous cheilitis and healthy volunteers, assessing barrier function through transepidermal water loss, stratum corneum hydration, pH, and erythema values. Short-term changes were measured at 15, 30, and 60 minutes post-application, and a case-control design was used to compare the 7-day efficacy of gauze wet dressing as an adjuvant therapy to topical glucocorticoid and petroleum jelly. Results indicated that patients exhibited decreased lip barrier function, which improved significantly with gauze wet dressing, enhancing hydration and normalizing pH levels within 30 minutes. The adjuvant treatment also showed more significant clinical improvement at 7 days compared to the control group, with notable restoration of barrier function and improvement in fissure phenotype. Furthermore, the study demonstrated that the application of gauze wet dressing not only increased stratum corneum hydration and normalized pH levels but also significantly improved the clinical condition of eczematous cheilitis over the 7-day treatment period. This suggests that gauze wet dressing, as an adjunct to standard therapy, provides a convenient and cost-effective method for enhancing lip barrier function and managing eczematous cheilitis, leading to better therapeutic outcomes and patient satisfaction.

Introduction Skin senescence leads to decreased lipid and water levels, inducing xerosis with compromised barrier function. Xerosis affects ≈56% of the aging population, usually characterized by skin scaling, itching, and cracking predominating on the lower legs, causing discomfort, limited mobility and increased risk of eczema/infections. With hydrating and barrier strengthening properties, urea-based topical moisturizers are commonly used to manage skin dryness. This observational, open label, single group study, conducted in 59 participants (60 75 years), evaluated the effectiveness, tolerability and patient benefits of a 10% urea based emollient ("U10%") in the management of moderate to severe senile xerosis of the lower legs. Methods Subjects applied U10% twice daily over 4 weeks. Clinical evaluations by physicians were conducted at Baseline and Day 28 to measure changes in hydration levels, barrier function, and skin texture. Patient-reported outcomes on treatment benefits and quality of life were recorded on Day 7 and Day 28. Results After 4 weeks of treatment, meaningful improvements were observed in the global clinical assessment scores of xerosis, overall dry skin, skin roughness and dryness, total xerosis severity of the lower legs, xerosis severity for erythema, lichenification, desquamation and body surface. Corneometry measurements showed decreased trans-epidermal water loss, in line with improvements in the skin barrier function. Patient-reported outcomes showed marked improvements indicating enhancement in the overall patient perception of benefit and in the patients' quality of life resulting from treatment. Conclusion This study has provided strong evidence for the potential use of U10% emollient as a highly effective solution tailored to meet unique needs of age-related xerosis and pruritus.

Physical exercise influences the function of multiple organs, including the skin. Previous studies demonstrated an increase in transepidermal water loss rates (TEWL) after exercise. However, TEWL measured shortly after exercise may not truly reflect the epidermal permeability barrier function. And the limited sample size may also affect the generalizability of the findings. Therefore, we assessed the influence of physical exercise on epidermal biophysical properties in a larger cohort prior to exercise.

Since skin tissues feature highly inter- and intraindividual variable scattering properties, it is of interest for fluorescence spectroscopy applied to skin cancer diagnostic assistance to be combined with a device able to measure scattering properties of skin tissues in vivo and further correct fluorescence spectra. This study aimed to explore the interest of combining two devices previously used in vivo during clinical trials: line-field confocal optical coherence tomography (LC-OCT) for scattering property estimation and fluorescence spectroscopy for measuring the modification of endogenous fluorescence induced by carcinogenesis.

The human epidermis is the interface between the　human body and the environment. It is mainly comprised of keratinocytes. Since the beginning of this century, functional expression of a series of receptors for various environmental factors has been reported. Moreover, neurotransmitters and hormones originally found in the central nervous system are generated and released from keratinocytes. Thus, the pathophysiology of the epidermis is important not only for skin health but also for whole-body conditions. In outer space, humans must confront environmental factors different from those on Earth, such as electromagnetic fields, drastic changes in atmospheric pressure or humidity, and microgravity. In this review, the author discusses the potential effects of these factors on epidermal homeostasis and whole-body conditions.

Stimulated skin wrinkling (SSW) reflects the integrity of the autonomic nervous system, eccrine sweat glands, and microcirculation. Specific stimuli, as water immersion or mechanical pressure usually elicit it. This study explored the influence of some physical, chemical, sympathetic stimuli, and circadian cycle on SSW.

Adrenergic modulation of sweating remains equivocal in females. We investigated whether α- and α-adrenergic receptors can modulate sweating during active heat stress in healthy female participants.

Introduction: In women during pregnancy and in infants during the first months after birth, skin health is challenged. However, evidence about the structural and functional changes of the skin during and after pregnancy is largely lacking.

Several complex mathematical models have been developed using in vitro permeation test (IVPT) data to characterize percutaneous absorption. A less complicated approach, using basic pharmacokinetic parameters on IVPT data, is proposed here to predict skin barrier content and permeation kinetics following multiple-dose applications.

Hypertrophic scars are common fibrotic disorders marked by fibroblast overgrowth and excessive extracellular matrix deposition, necessitating further research into their formation mechanisms to improve treatment outcomes. The study investigated the clinical significance and potential mechanisms of long noncoding RNA (lncRNA) HCP5 in the development of hypertrophic scars in human fibroblasts.

A new method for conducting in vitro release testing (IVRT) was developed by adapting Higuchi's square root approximation for use with UV-Vis spectrophotometry, and over the counter hydrocortisone formulations at 0.5% and 1.0% concentrations. This IVRT method was investigated for the required validation elements as specified by abbreviated new drug applications (ANDAs) and USP General Chapter <1724> for linearity and range, precision and reproducibility, and discrimination sensitivity, specificity, and selectivity.

Emulsifiers are common excipients in dermal products stabilizing formulations such as creams and emulsions. But due to their potential for skin irritation, emulsifiers for pharmaceutical use should be tested regarding their tolerability before introducing them to the skin of patients. In this study, a systematic investigation with six oil in water-emulsifiers was performed on the forearms of 12 healthy human volunteers, six female, and six male.

The in vitro Permeation Test (IVPT) is considered to be an important tool for assessing the topical pharmacokinetics of dermatologic formulations. An IVPT study evaluating products that contain the skin bleaching agent, hydroquinone (HQ), as the active ingredient, is presented in support of the value of IVPT in comparing the relative bioavailability of HQ products from different commercial products.

Understanding skin aging and developing effective interventions represent fundamental challenges in dermatology. Key mechanisms driving this process include complex interactions among cellular senescence, extracellular matrix remodeling, oxidative stress, and inflammatory networks.

Changes in the skin microbiome in atopic dermatitis (AD) include a reduced bacterial diversity and increased abundance of Staphylococcus aureus. Topical antibiotics and antiseptics may decrease bacterial pathogens but lack positive effects on microbiome diversity.

The skin serves as a barrier, preventing internal moisture loss and protecting against the invasion of external harmful factors while also playing a role in immune responses. Barrier disruption is a hallmark of inflammatory skin diseases characterized by dryness and itching, notably in conditions like atopic dermatitis (AD). Recent research has focused on exploring novel compounds that can enhance skin barrier function and modulate inflammatory responses. Therefore, this study aimed to investigate the barrier-protective role and underlying mechanisms of lipimoide in an AD-like skin barrier impairment model using normal human keratinocytes and human skin equivalent models.

Diabetic foot ulcers (DFUs) are a common complication in diabetes, leading to high amputation risk and significant healthcare costs. Given topical timolol's emergence as a potential wound-healing agent, our study explored its impact on epidermal integrity.

Despite numerous therapeutic approaches, keloid treatment remains a challenge. Clinical studies have demonstrated the possible use of cold atmospheric plasma (CAP) to treat hypertrophic scars and keloids. This study investigated the effects and relative mechanisms of CAP treatment on primary keloid fibroblasts (PKF) in vitro.

Regular use of leave-on skincare products has positive effects on the skin barrier and appears to influence the skin microbiome in atopic dermatitis (AD). However, product-related effects on the skin microbiome are unclear. The aim of this study was to investigate to which extent the application of an emollient plus product differs from a petrolatum-based basic skincare product in terms of skin physiology, skin barrier, and skin microbiome.

The major carriers of linoleic acid in the epidermis are an acylglucosylceramide in the viable portion of the epidermis and an analogous acylceramide in the stratum corneum. The acylglucosylceramide and acylceramide are the precursors of the corneocyte lipid envelope (CLE).