This paper aims at identifying the current main economic thought influencing the EU Cohesion Policy. Postulates and assumptions on how economic growth spreads spatially in key EU policy framework documents are discussed and compared to different economic theories. Strategic EU documents increasingly foster the urban dimension, and focus resources on cities at the expense of cohesive regional development. The findings indicate large overlaps with Perroux' 'growth pole theory'. However, several of the key assumptions of growth pole theory are not met in the new context of post-industrial globalized service economy, which is fundamentally different from its original use. This is a troublesome finding when seen from a strategic planning perspective. Current implications for regional policy and planning boil down to the cardinal question of supporting urban areas and/or peripheries. Taking the strategic EU policy documents and their trajectories in economic thought into consideration, this paper confirms that regional development focuses on cities. Yet, it suggests a new perspective on an urban-centred EU Cohesion Policy, one that normatively requests the 'responsibility' of cities towards their hinterland, instead of fostering a further dissociation of cities from their hinterland. This suggests a reorientation towards supporting the linkages between urban areas and peripheries.