CLINICAL AND EXPERIMENTAL DERMATOLOGY

3-dimensional stereophotogrammetry: an effective tool for detecting disease progression in lupus erythematosus panniculitis
Hashemi KB, Ortiz-López LI, Santiago-Soltero KM, Nguyen TT, Castillo RL, Dedeoglu F, Ganske IM, Shaw KS and Vleugels RA
Successful lanadelumab dose spacing in type I hereditary angioedema
Teixeira J, Flor D, Xará J and Gonçalo M
Herpes vegetans mimicking penile malignancy in a patient living with human immunodeficiency virus
Larney C, Osti M, Jiang J and Lasocki A
A unique case of steroid-resistant, giant cellulitis-like Sweet syndrome mimicking alpha-1-antitrypsin deficiency-associated panniculitis: successful treatment with dapsone
Maronese CA, Croci GA, Derlino F, Aromolo IF, Moltrasio C and Marzano AV
Comment on 'Differential diagnosis of red scalp: the importance of trichoscopy'
Garcia Bielsa C, Caballero-Uribe N and Trüeb RM
The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program
Chen GF, Shipman WD, Hodelin C, Hsia HC, Cohen JM and Eisenstein A
Two Cases of Drug-Induced Psoriasis from Second Generation Androgen Receptor Blockers
Buttars B, Baltazar D, Chares G, Flaherty A, Hamann D, Whittemore D and Hamann C
Correction to: Human papillomavirus detection rates in Bowen disease: correlation with pelvic and digital region involvement and specific p53 immunostaining patterns
General dermatology and dermatology in primary health care
Bučić D, Darcis G and El Moussaoui M
Effectiveness of wide local excision and secondary intention healing in Hidradenitis Suppurativa: a single-center study on quality of life and mental health outcomes
Michelucci A, Margiotta FM, Salvia G, Vietina A, Janowska A, Morganti R, Romanelli M and Dini V
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that significantly impacts patients' quality of life and mental health. Effective management often involves both medical and surgical interventions. The aim of the study was to assess the effectiveness of wide local excision and secondary intention healing in improving quality of life and mental health in patients with moderate to severe HS.
Efficacy and tolerability of 1.6% phenol-croton peeling versus topical 5% imiquimod in the treatment of actinic cheilitis: a randomized clinical trial
Garbers LEFM, Miola AC, de Souza V, Brommonschenkel CC, Lima FO, Minicucci EM and Miot HA
Trials evaluating the effectiveness of topical treatments for actinic cheilitis (AC) are scarce. Despite no comparative data, phenol-croton peeling has been reported as effective in treating this condition.
Itching for innovation: role of aryl hydrocarbon receptor agonists as a future therapy for atopic dermatitis
Wazir A and O'Toole EA
Atopic dermatitis (AD) is a chronic, inflammatory skin condition which affects over 200 million people worldwide, with patients commonly presenting with dry, itchy and sore skin. The challenge in finding optimal treatment for AD stems from the heterogenous nature of the disease and its multifaceted aetiology: skin barrier dysfunction, immune system dysregulation, genetic factors, environmental factors and alterations in skin microorganisms. Traditional treatments for AD such as corticosteroids, calcineurin inhibitors and immunosuppressants have several limitations such as reoccurrence of symptoms when discontinued, lack of targeted action and risk of adverse effects. The aim of this literature review was to explore and summarise the role of aryl hydrocarbon receptor (AHR) agonists (namely Tapinarof) as potential future therapy for AD. AHR agonists hope to overcome the limitations of traditional AD therapies and exert their therapeutic value by maintaining integrity of the skin barrier, defending against oxidative stress, modulating immune activity and inflammation and restoring a healthy skin microbiome. Tapinarof, a topical AHR agonist, is showing promising results and is currently in phase 3 trials (ADORING 3). For Tapinarof to be integrated into the AD treatment pathway, further research must be conducted on its efficacy, durability, potential remittive effect and safety across different AD subtypes in a large, diverse patient population. In addition, Tapinarof's cost-effectiveness compared to its topical counterparts needs to be considered and multidisciplinary collaboration is required between researchers, clinicians and policy makers.
Clinicopathological Characteristics and Favorable Prognosis of Pediatric Cutaneous Nodular Fasciitis: A Case Series
Zhao M, Han X, Wei L, Sun J, Li X and Liang Y
Cutaneous nodular fasciitis (cNF) is a rare benign myofibroblastic proliferation commonly misdiagnosed as malignancy due to its rapid growth and histological features. This study reviews 15 pediatric cNF cases, highlighting clinical, histological, and molecular characteristics. The median age was 6 years, with a predilection for the head and neck region. Histologically, cNF showed plump spindle cells and myxoid stromal changes. USP6 gene rearrangement, particularly MYH9-USP6 fusion, was present in the majority of cases. Spontaneous resolution was observed in non-surgically managed cases. Accurate diagnosis through USP6 rearrangement screening is essential to avoid overtreatment. This study underscores cNF's benign nature and the importance of conservative management, especially in cosmetically sensitive areas.
Mobile Subcutaneous Tumor on the Trapezius
Konisky H, Villanueva-Siles E and Kobets K
A review of consent policies in Dermatological Surgery in the United Kingdom and the impact of leaner pathways and teledermatology on consent
Potluru A, Sokol D and Wernham A
Obtaining valid consent is an ethical and legal requirement in clinical practice, ensuring patients are adequately informed about their treatments. Recent updates in consent policies, including GMC guidance, the Patterson inquiry report, and key legal rulings like Montgomery, emphasise a shift towards patient-centred care and the importance of a comprehensive patient-clinician dialogue. Budget constraints and increasing NHS demand have led to the adoption of digital solutions and streamlined pathways, such as teledermatology and direct booking to surgery, potentially compromising the consent process. This review examines the current state of informed consent in UK dermatology, particularly in light of the Montgomery ruling, which requires clinicians to ensure patients are aware of all material risks and alternatives associated with their treatments. The two-stage consent process, involving consent at two distinct points, is advocated to allow patients adequate time for reflection and decision-making. However, challenges remain in pathways like one-stop clinics and direct booking for surgery, where limited face-to-face interaction and time constraints can undermine the quality of informed consent. To mitigate these issues, integrating multimedia tools and standardised procedure-specific consent forms can enhance patient comprehension and satisfaction. These tools ensure consistent and clear communication of risks, benefits, and alternatives, maintaining robust informed consent amidst evolving healthcare delivery models. Sustaining a thorough and individualised dialogue throughout the patient care journey is essential for upholding patient autonomy and shared decision-making in dermatological surgery.
Inpatient Dermatology referrals: What is the burden? A retrospective review of 14 years of dermatology inpatient referrals
Cnudde MAM, Aldridge C and Thomas C
The lack of dermatological knowledge by non-dermatologists is exposed by the increasing number of requests made for inpatient dermatological consultations. Patients have been commenced on inappropriate treatment because of poor dermatology training.
Multiple Abscesses and Plaques in an Immunocompetent Patient
Fanous N, Clarke E and Nguyen KD
Correction to: Treatment of Behçet disease with oral roflumilast: an observational study
Evaluating the content and utilization of UV index smartphone applications
Ahmad AS, Coleman MS, O'Connell KA, Zheng DX and Buzney EA
Comment on 'A cross-sectional analysis of TikTok content relating to sunscreen conspiracy theories and correlation with published evidence on sunscreen risks': Debunking Sunscreen Myths and Trends - Lessons for Dermatology Educators
Nikookam Y, Potluru A and Guckian J
Trends in incidence, mortality, and survival of cutaneous malignant melanoma over three decades: a population-based study in Southern Spain
Ródenas-Herranz T, Rodriguez-Barranco M, Petrova D, Pérez-Gómez B, Ruiz-Villaverde R and Sánchez MJ
Cutaneous malignant melanoma (CMM) represents a global public health problem. Epidemiological studies about CMM trends tend to focus on single indicators or lack information about tumor characteristics that can help gain a more thorough understanding of CMM epidemiology.