ARTHRITIS CARE & RESEARCH

The State of the Advanced Practice Provider in Rheumatology
Carnago L and Dimsdale A
Occupational and Hobby Exposures Associated with Myositis Phenotypes in a National Myositis Patient Registry
Parks CG, Wilkerson J, Rose KM, Faiq A, Farhadi PN, Bayat N, Schiffenbauer A, Brunner HI, Goldberg B, Sandler DP, Miller FW and Rider LG
To investigate occupational and hobby exposures to silica, solvents, and heavy metals and odds of idiopathic inflammatory myositis (IIM) phenotypes, dermatomyositis (DM) and polymyositis (PM) versus inclusion body myositis (IBM), lung disease plus fever or arthritis (LD+), and systemic autoimmune rheumatic disease-overlap myositis (OM).
Profile and Attributes of Physician Assistants/Associates in Rheumatology: An In-depth Analysis
Smith BJ, Hooker RS, Bruza-Augatis M, Puckett K and Kozikowski A
This work describes the demographics and practice characteristics of physician assistants/associates (PAs) practicing in rheumatology.
Incidence of and risk of mortality after hip fractures in Rheumatoid Arthritis relative to the general population
Jones CA, Guy P, Xie H, Sayre EC, Zhao K and Lacaille D
Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in RA patients treated with contemporary treatment strategies are lacking. The objectives were 1) to estimate age- and sex-specific incidence rates and compare the risk of hip fractures in RA relative to age and sex-matched general population controls, and 2) to compare the risk of all-cause mortality in RA and general population controls after hip fracture.
Developing a Novel Surgical Care Access Score for Osteoarthritis Patients Considering Total Knee Replacement
Ghomrawi HMK, Huang LW, Credit K, Lotfata A, Malhotra A, Patel AM, Franklin P, French DD and Block D
Access to specialized orthopedic care is an important determinant of the decision to undergo total knee replacement (TKR); however, most studies have mainly utilized distance to the nearest high-volume hospital as the primary proxy for access. We applied the two-step floating catchment area (2SFCA) method to develop a more comprehensive TKR access score that accounts for other potential factors, i.e., supply of and demand for this procedure, that also affect access.
Immunosuppressive Drugs in Early Limited Cutaneous Systemic Sclerosis May Prevent Global Damage Accrual
Baron M, Nikpour M, Hansen D, Proudman S, Stevens W, and Wang M
Organ damage in systemic sclerosis (SSc) in individual organs such as the lungs may be prevented by immunosuppressive drugs (IS). A new measure of global organ damage, the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI), has allowed us to investigate whether IS may reduce global organ damage accrual in early SSc.
Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients with Polyarticular-Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open-label, Phase 1 Trial
Brunner HI, Shmagel A, Horneff G, Foeldvari I, Antón J, Ramanan AV, Qian Y, Unnebrink K, Hao S, Camp HS, Khan N, Liu W and Mohamed MF
This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular-course juvenile idiopathic arthritis (pcJIA).
National Institute of Health and Care Excellence Clinical Criteria for the Diagnosis of Knee Osteoarthritis: A Prospective Diagnostic Accuracy Study in Individuals with Type 2 Diabetes
King LK, Stanaitis I, Hung V, Koppikar S, Waugh EJ, Lipscombe L and Hawker GA
The National Institute of Health and Care Excellence (NICE) criteria for osteoarthritis (OA) obviate the need for physical exam or imaging, and their use may improve timely diagnosis of OA. However, they have not been validated.
Oral glucocorticoids for skin fibrosis in early diffuse systemic sclerosis: a target trial emulation study from the European Scleroderma Trials and Research group database
Mongin D, Matucci-Cerinic M, Walker UA, Distler O, Becvar R, Siegert E, Ananyeva LP, Smith V, Alegre-Sancho JJ, Yavuz S, Limonta M, Riemekasten G, Rezus E, Vonk M, Truchetet ME, Del Galdo F, Courvoisier DS, Iudici M and
The objective of this study is to evaluate whether adding oral glucocorticoids to immunosuppressive therapy improves skin scores and ensures safety in patients with early diffuse cutaneous systemic sclerosis (dcSSc).
Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction
Eloseily E, Pickering A, Dhakal S, Ruperto N, Brunner HI, Grom AA, Thornton S and
To assess changes in gene expression following tofacitinib treatment and investigate transcription patterns as potential predictors of treatment response in patients with active juvenile idiopathic arthritis (JIA).
Barriers to Total Joint Arthroplasty: A Comparison of High-Poverty and Low-Poverty Communities
Gibbons JAB, Mannstadt I, Amen T, Rajan M, Young SR, Parks ML, Figgie M, Bass A, Russell L, Mehta B, Navarro-Millán I and Goodman SM
Our aim was to determine the most significant barriers to total joint arthroplasty (TJA) for people living in high-poverty communities relative to low-poverty communities.
Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity
Messier SP, Monroe MG, Callahan LF, Mihalko SL, Beavers DP, Queen K, Miller GD, Losina E, Katz JN, Loeser RF, DeVita P, Hunter DJ and Quandt SA
The study objective was to determine whether the clinical response of older adults with knee osteoarthritis and overweight or obesity to 18 months of diet and exercise (D + E) or attention control (C) interventions differed between participants from rural versus urban communities.
Determinants of self-management behavior in gout: a scoping review
van der Ven J, van den Bemt BJF, Flendrie M, Vriezekolk JE and Verhoef LM
This study aimed to identify modifiable determinants of self-management behavior in gout.
Impact of Season, Environmental Temperature, and Humidity on Raynaud Phenomenon in an Australian Systemic Sclerosis Cohort
Taylor L, Hansen D, Morrisroe K, Fairley J, Calderone A, Oon S, Ross L, Stevens W, Ferdowsi N, Quinlivan A, Sahhar J, Ngian GS, Apostolopoulos D, Host LV, Walker J, Tabesh M, Proudman S and Nikpour M
The aim of this study was to determine the impact of season, temperature and humidity on the severity of Raynaud phenomenon (RP) in systemic sclerosis.
Evaluating Criteria for Symptoms Suggestive of Early Osteoarthritis Over Two Years Post-Anterior Cruciate Ligament Reconstruction: Data From the New Zealand Anterior Cruciate Ligament Registry
Harkey MS, Driban JB, Todem D, Kuenze C, Mahmoudian A, Meiring R, O'Brien D and Ward S
The objectives were to determine the prevalence of meeting criteria for symptoms suggestive of early osteoarthritis (OA) after anterior cruciate ligament reconstruction (ACLR) and to characterize the longitudinal changes in these symptoms during the first two years post-ACLR.
Improving Identification of At-Risk Behaviors in Adolescents With Rheumatic Disease
Ciaglia K, Lau M, Jo CH and Nassi L
Many adolescent patients view their rheumatologist as their primary physician, and therefore it is important to screen youth for sexual activity and substance use as recommended by the American Academy of Pediatrics. We implemented an electronic social history questionnaire (SHQ) and alert system to identify at-risk behaviors in adolescents with rheumatic disease.
Building the OAChangeMap to Improve the Service Delivery of the New South Wales Osteoarthritis Chronic Care Program: A Worked Example of Using a Codesign Framework
Eyles JP, Kobayashi S, Duong V, Hunter DJ, Avdalis C, Buttel T, Dawson G, Dório M, D'Souza N, Foster K, Maka K, March MK, Menz F, Pratt C, Rankin NM, Richardson D, Thompson J, Strong C and Bowden JL
The Osteoarthritis Chronic Care Program (OACCP) has been implemented in Australian public hospitals to deliver best evidence osteoarthritis (OA) care. It is important to ensure that the OACCP continues to deliver evidence-based OA care as intended. We aimed to identify barriers and enablers to delivering the OACCP, prioritize the barriers, and generate strategies to address them.
Sleep Efficiency Mediates the Association Between Neighborhood Disadvantage and Knee Osteoarthritis Pain: Findings from the Understanding Pain and Limitations in Osteoarthritic Disease Study 2
Huber FA, Gonzalez C, Kusko DA, Mickle A, Sibille KT, Redden DT, Azuero CB, Staud R, Fillingim RB and Goodin BR
The objective was to examine potential pathways linking neighborhood disadvantage to pain severity in individuals with knee pain consistent with or at risk for Knee Osteoarthritis (KOA).
Comparing Rituximab and Cyclophosphamide in Induction Therapy for Childhood-Onset ANCA-Associated Vasculitis: An ARChiVe registry-cohort study
Gagne SJ, Sivaraman V, Bosman ES, Klamer B, Morishita KA, Huber A, Orjuela A, Eberhard B, Myrup C, Gerstbacher D, Foell D, Al-Abadi E, McErlane F, Cook K, Wagner-Weiner L, Elder M, Moorthy LN, Dancey P, Yeung R, Khubchandani R, Deepak S, Charuvanij S, Tarvin S, Shenoi S, Tanner T, Brown K, Cabral DA and
Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are chronic life-threatening vasculitides requiring substantial immunotherapy. Adult trials identified rituximab (RTX) as an alternative to cyclophosphamide (CYC) for remission-induction of GPA/MPA. Disease rarity has limited feasibility of similar trials in pediatrics. We aim to evaluate the relative efficacy and toxicity of CYC and RTX for childhood GPA/MPA through registry-based comparative evaluation.
Escalation to Biologics After Methotrexate Among US Veterans with Rheumatoid Arthritis Grouped by Rural Versus Urban Areas
Naik A, Baraff A, Wysham KD, Liew JW, England BR, Roul P, George M, Baker JF, Barton JL, Makris UE, Kerr G, Cannon GW, Mikuls TR and Singh N
Racial and ethnic disparities in rheumatoid arthritis (RA) outcomes are well recognized. However, whether disparities in RA treatment selection and outcomes differ by urban versus rural residence, independent of race, have not been studied. Our objective was to evaluate whether biologic disease modifying anti-rheumatic drugs (bDMARD) initiation after methotrexate use differs by rural versus urban residence among Veterans with RA.
Area-level socioeconomic status impacts healthcare visit frequency by Australian inflammatory arthritis patients: results from the Australian Rheumatology Association Database
Russell O, Lester S, Black RJ, Lassere M, Barrett C, March L, Lynch T, Buchbinder R and Hill CL
Individuals with inflammatory arthritis (IA) require long-term rheumatologist care for optimal outcomes. We sought to determine if socioeconomic status (SES) influences general practitioner (GP) and specialist physician visit frequency and out of pocket (OOP) visit costs.