Skin manifestations in a patient with acute bacterial infective endocarditis
The PRECISE trial: How should patients with chest pain be tested?
It's time for a little history of medicine-introducing a new feature in
Cervical cancer screening in high-risk patients: Clinical challenges in primary care
The risk of developing cervical cancer is not equal across populations-individual health history, economic, political, and societal factors influence cervical cancer risk. Certain health conditions, including human immunodeficiency virus (HIV) infection, immunosuppression, and history of high-grade cervical dysplasia, are associated with higher cervical cancer risk and warrant distinct screening, surveillance, and management guidelines. It is imperative for clinicians to recognize high-risk groups and apply appropriate corresponding guidelines. However, this can be difficult in practice, as recommendations regularly evolve. This review offers up-to-date guidance in a case-based format on cervical cancer screening, surveillance, and management for high-risk patients.
The history of blood cultures: From the research laboratory to the bedside
Effective but inaccessible antiobesity medications: A call for sharing responsibility for improving access to evidence-based care
What are options for my patients with erectile dysfunction who have an unsatisfactory response to PDE5 inhibitors?
A man with chronic limb-threatening ischemia and no revascularization options: Can we save his foot?
Abdominal pain in a patient with epistaxis, telangiectasias, and arteriovenous malformations
Using continuous glucose monitoring data in daily clinical practice
Access to and use of glycemic data are central to optimal management of diabetes. Use of continuous glucose monitoring (CGM) data to guide the management of diabetes has increased dramatically thanks to improved ease of use, accuracy, and availability. Retrospective CGM data collected throughout the day and night allow clinicians to visualize glycemic patterns, and single-page summary views like the Ambulatory Glucose Profile (AGP) Report make rapid interpretation both feasible and intuitive. A systematic approach that integrates retrospective CGM-generated data at clinic visits and other clinical interactions with personal use of CGM data can optimize glycemic management.
Incidentally detected noninfectious thoracic aortitis: A clinical approach
Noninfectious aortitis is occasionally detected incidentally, either on imaging or on histopathologic review after open thoracic aortic surgery. It can present as a clinically asymptomatic, seemingly focal lesion, as diffuse inflammation throughout several aortic segments but sparing the branch vessels, or as a manifestation of a widespread systemic condition. Treatment differs based on etiology, so once identified, all patients with aortitis need a thorough evaluation, laboratory tests, complete large-vessel imaging, and a referral to a vasculitis expert. All patients with aortitis are at high risk of future vascular complications and should be followed with serial clinical evaluations and imaging.
Continuous glucose monitoring: High-tech devices still need some low-tech backup
Having the conversation: Individualizing RSV vaccination in older patients
The new vaccines against respiratory syncytial virus (RSV) reduce the risk of RSV illness, which is common in older people and carries the risk of hospitalization with its attendant risks such as delirium and physical decline leading to loss of function and independence. Individualized discussions regarding vaccination should weigh the risks of vaccination, which are minor, against the preventive benefits. Discussions incorporating these elements may lead to greater vaccine uptake, especially by those at high risk.
RSV immunization in adults and children: A practical guide for clinicians
In 2023 and 2024, 3 vaccines were approved by the US Food and Drug Administration (FDA) against respiratory syncytial virus (RSV) in adults. In addition, the first long-acting RSV monoclonal antibody for infants and young children was approved. This review provides clinicians with practical guidance to navigate this new era of RSV prevention.
Respiratory viruses: Preventive and therapeutic approaches to diverse pathogens
Viral respiratory diseases affect millions of individuals worldwide each year. Annual vaccinations are recommended by the World Health Organization for some of them, such as influenza and more recently for the coronavirus disease of 2019 (COVID-19) and respiratory syncytial virus, with the goal of reducing disease severity and limiting transmission. In the context of infection and vaccination, it is of primary importance to evaluate the immune response to pathogens to shed light on the mechanisms of protection.
