Mucoadhesion is a special case of bioadhesion in which a material adheres to soft mucosal tissues. This review elucidates our current understanding of mucoadhesion across length, time, and energy scales by focusing on relevant structural features of mucus. We highlight the importance of both covalent and non-covalent interactions that can be tailored to maximize mucoadhesive interactions, particularly concerning proteinaceous mucoadhesives, which have been explored only to a limited extent so far in the literature. In particular, we highlight the importance of thiol groups, hydrophobic moieties, and charged species inherent to proteins as key levers to fine tune mucoadhesive performance. Some aspects of protein surface modification by grafting specific functional groups or coupling with polysaccharides to influence mucoadhesive performance are examined. Insights from this review offer a physicochemical roadmap to inform the development of biocompatible, protein-based mucoadhesive systems that can fulfil dual roles for both adhesion and delivery of actives, enabling the fabrication of advanced biomedical, nutritional and allied soft material technologies.

Magnetic nanoparticles (MNPs) have garnered significant attention from researchers due to their numerous technologically significant applications in diverse fields, including biomedicine, diagnostics, agriculture, optics, mechanics, electronics, sensing technology, catalysis, and environmental remediation. The superparamagnetic nature of MNP is exploited for many applications and remains fascinating to study many fundamental phenomena. The uniqueness of this review is that it gives an in-depth review of different synthesis approaches adopted for preparing magnetic nanoparticles and nanoparticle formation mechanisms, functionalizing them with different capping agents, and applying different functionalized magnetic nanoparticles. The important synthesis techniques covered include coprecipitation, microwave-assisted, sonochemical, sol-gel, microemulsion, hydrothermal/solvothermal, thermal decomposition, and mechano-chemical synthesis. Further, the advantages and disadvantages of each technique are discussed, and tables show important results of prepared particles. Other aspects covered in this review are the dispersion of magnetic nanoparticles in the continuous matrix, the influence of surface capping on high-temperature thermal stability, the long-term stability of ferrofluids, and applications of functionalized magnetic nanoparticles. For effective utilization of the ferrite nanoparticles, it is essential to formulate thermally and colloidally stable magnetic nanoparticles with desired magnetic properties. Capping enhances the phase transition temperature and long-term colloidal stability. Magnetic nanoparticles capped or functionalized with specific binding species, specific components like drugs, or other functional groups make them suitable for applications in biotechnology/biomedicine. Recent studies reveal the tremendous scope of MNPs in therapeutics and theranostics. The requirements for nanoparticle size, morphology, and physio-chemical properties, especially magnetic properties, functionalization, and stability, vary with applications. There are also challenges for precise size control and the cost-effective production of nanoparticles in large quantities. The review should be an ideal material for researchers working on magnetic nanomaterials and an excellent reference for freshers.

Nanoparticles are vital to a broad range of applications including commercial formulations, sensing and advanced material synthesis. Nanoparticles can come in a variety of shapes including cubes, polyhedra, rods, and prisms, and recent literature has demonstrated the importance of nanoparticle shape to downstream function (such as cellular uptake). While researchers routinely characterise nanoparticle shape using electron microscopy techniques, this generally requires drying of the samples. Many particles (e.g. lipid nanoparticles or polymer particles) change with drying, so complementary solution based techniques are needed. Scattering techniques can be used to characterise such nanoparticles in suspension, overcoming many of the limitations of other techniques. Here we review the current state of the art in the characterisation of complex nanoparticles (non-spherical and multi-layered) using advanced scattering techniques including light, X-ray, and neutron scattering. Recent improvements in instrument availability and data analysis makes these techniques much more accessible to researchers. This review provides an introduction to these techniques aimed at all researchers working with nanoparticles, in the hope that full characterisation of nanoparticles in solution becomes standard practice.

Montmorillonite (Mt) is one of the eco-friendly and low-cost nano-adsorbents for water and wastewater treatment. Interactions of Mt. with various modifiers such as surfactants and polymers make it an ideal adsorbent with good selectivity for the removal of phenols, heavy metals and drug residues from water and wastewater. Surface modification can improve the adsorption potential of Mt. due to increasing the number of adsorption sites and functional groups to remove a wide variety of contaminants. This paper shows a general overview of the structure, adsorptive characteristics, and applications of Mt. and modified Mt. (m-Mt). Also, recent progress made in using of natural and modified bentonite and Mt. for removing phenols, heavy metals and pharmaceuticals from water and wastewater are explained. Furthermore, it discusses the strategies used to increase the adsorption capacity of Mt. by surface modification with cationic surfactants, acids, and polymers. This article delivers an exploration of the current uses of bentonite and Mt. for water and wastewater treatment and encouraging results obtained in this review could aid in the application Mt. and m-Mt for the recovery of high added value compounds and removal of contaminants from aquatic systems.

Cancer theranostic is the combination of diagnosis and therapeutic modalities for cancer treatment. It realizes a more flexible, precise and non-invasive treatment of patients. In this aspect, magnetic nanostructures (MNSs) have gained paramount importance and revolutionized the cancer management due to their unique physicochemical properties and inherent magnetic characteristics. MNSs have amazing theranostic ability starting from drug delivery to magnetic hyperthermia and magnetic resonance imaging to multimodal imaging in association with radioisotopes or fluorescent probes. Precise regulation over the synthetic process and their consequent surface functionalization makes them even more fascinating. The ultimate goal is to develop a platform that combines multiple diagnostic and therapeutic functionalities based on MNSs. This perspective has provided an overview of the state-of-art of theranostic applications of MNSs. Special emphasis has been dedicated towards the importance of synthetic approaches of MNSs as well as their subsequent surface engineering and integration with biological/therapeutic molecules that decide the final outcomes of the efficacy of MNSs in theranostic applications. Moreover, the recent advancements, opportunities and allied challenges towards clinical applications of MNSs in cancer management have been demonstrated.

We noticed that in literature, the term Pickering emulsion (PE) is used as soon as ingredients contain particles, and in this review, we ask ourselves if that is done rightfully so. The basic behavior taking place in particle-stabilized emulsions leads to the conclusion that the desorption energy of particles is generally high making particles highly suited to physically stabilize emulsions. Exceptions are particles with extreme contact angles or systems with very low interfacial tension. Particles used in food and biobased applications are soft, can deform when adsorbed, and most probably have molecules extending into both phases thus increasing desorption energy. Besides, surface-active components will be present either in the ingredients or generated by the emulsification process used, which will reduce the energy of desorption, either by reduced interfacial tension, or changes in the contact angle. In this paper, we describe the relative relevance of these aspects, and how to distinguish them in practice. Practical food emulsions may derive part of their stability from the presence of particles, but most likely have mixed interfaces, and are thus not PEs. Especially when small particles are used to stabilize (sub)micrometer droplets, emulsions may become unstable upon receiving a heat treatment. Stability can be enhanced by connecting the particles or creating network that spans the product, albeit this goes beyond classical Pickering stabilization. Through the architecture of PEs, special functionalities can be created, such as reduction of lipid oxidation, and controlled release features.

Nanotechnology-based delivery systems have brought a paradigm shift in the management of cancer. However, the main obstacles to nanocarrier-based delivery are their limited circulation duration, excessive immune clearance, inefficiency in interacting effectively in a biological context and overcoming biological barriers. This demands effective engineering of nanocarriers to achieve maximum efficacy. Nanocarriers can be maneuvered with biological components to acquire biological identity for further regulating their biodistribution and cell-to-cell cross-talk. Thus, the integration of synthetic and biological components to deliver therapeutic cargo is called a biohybrid delivery system. These delivery systems possess the advantage of synthetic nanocarriers, such as high drug loading, engineerable surface, reproducibility, adequate communication and immune evasion ability of biological constituents. The biohybrid delivery vectors offer an excellent opportunity to harness the synergistic properties of the best entities of the two worlds for improved therapeutic outputs. The major spotlights of this review are different biological components, synthetic counterparts of biohybrid nanocarriers, recent advances in hybridization techniques, and the design of biohybrid delivery systems for cancer therapy. Moreover, this review provides an overview of biohybrid systems with therapeutic and diagnostic applications. In a nutshell, this article summarizes the advantages and limitations of various biohybrid nano-platforms, their clinical potential and future directions for successful translation in cancer management.

Metallic corrosion leads to high economic losses and security risks, and coating protection is an effective approach to preventing metal from corrosion. However, defects such as cracks and micropores are inevitable in the coating, so it is urgent to develop self-healing coatings for realizing long-term corrosion protection due to the actively protective ability. Though two-dimensional (2D) transition metal carbide or nitride (MXene) coatings have been employed to realize self-healing function, the design strategies of the MXene-based coatings and mechanism on how MXenes inhibit corrosion at the coating-metal interface as well as the roles of MXene in self-healing process remain elusive. In this review, the traditional self-healing coatings and the mechanisms were briefly introduced. Subsequently, the MXene and its anti-corrosive property were discussed. Then, the design and properties of self-healing MXene coatings (synergy with Ce, layered double hydroxide, inhibitors, and self-healing polymer) were further discussed. Importantly, the currently proposed self-healing mechanisms of the MXene coatings were summarized and analyzed. Finally, the challenges and prospects for the self-healing MXene coatings were proposed. This review can provide guidance of designing and understanding the mechanisms of the self-healing MXene coatings. It would expand the practical application of 2D MXene on corrosion protection.

The emergence of smart textiles with the ability to regulate body temperature, monitor human motion, exhibit antibacterial properties, sound fire alarms, and offer fire resistance has sparked considerable interest in recently. MXene displays remarkable attributes like high metallic conductivity, electromagnetic shielding capability, and photothermal/electrothermal properties. Furthermore, due to the highly polar surface groups, MXene nanosheets show exceptional hydrophilic properties and are able to establish strong connections with the polar surfaces of natural fabrics. This review focuses on the most recent developments in altering the surface of cellulosic textiles with MXene and MXene-based composites. The combination of MXene with other modifier agents, such as phosphorous compounds, graphene, carbon nanotube, conductive polymers, antibacterial macromolecules, superhydrophobic polymers, and metal or metal oxide nanoparticles, imparts diverse functionalities to textiles, such as self-cleaning and fire resistance. Moreover, the synergistic effects between these modifier agents with MXenes can improve MXene-related properties like antibacterial, photothermal, electrothermal, and motion- and fire-sensing characteristics.

This paper concerns the viscoelastic properties and the resulting structure of colloidal systems with short-range attractions in the regime where the volume fraction f is small. Unlike the high ϕ regime, which is well understood in terms of mode-coupling theory (MCT), the low ϕ regime is still the subject of a debate based on different concepts such as percolation, diffusion-limited colloidal aggregation (DLCA), jamming, or cluster mode-coupling approach. Prior to the analysis of three examples of attractive systems at low ϕ values, a summary of concepts relevant to understanding the formation and properties of such attractive particles is discussed in the present study. Afterwards, we re-analyze the behaviour at a low ϕ of i) suspensions of carbon black (CB) particles, ii) suspensions of poly(methyl methacrylate) (PMMA) hard spheres with a depletion attraction induced by the addition of polystyrene (PS), and iii) suspensions of amino acid organogelator molecules which form rod-like objects. The rheological properties of these systems have been studied in detail and their response has been interpreted as being due either to a solid network discussed in relation to the jamming state diagram or to a suspension formed by jamming of clusters. Our analysis shows that these three systems are in fact cluster fluids and that their solid-like response corresponds to a change in their viscoelastic response, the elastic component G' becoming greater than the viscous component G" at low frequencies. Due to the presence of weak interparticle interactions in the tens range from 1 to 15 kT, a liquid-like state is reversibly achieved at high frequencies, as indicated by the crossover of G' and G" as a function of frequency for a given concentration. Moreover, all these attractive particle systems at low ϕ show for both moduli a master curve which characterizes these cluster fluids and allows for the classification of these attractive particle systems.

To date, genetically modified organoids are emerging as a promising 3D modeling tool aimed at solving genetically relevant clinical and biomedical problems for regenerative medicine and tissue engineering. As an optimal vehicle for gene delivery, genetically modified organoids can enhance or reduce the expression of target genes through virus and non-virus-based gene transfection methods to achieve tissue regeneration. Animal experiments and preclinical studies have demonstrated the beneficial role of genetically modified organoids in various aspects of organ regeneration, including thymus, lacrimal glands, brain, lung, kidney, photoreceptors, etc. Furthermore, the technology offers a potential treatment option for various diseases, such as Fabry disease, non-alcoholic steatohepatitis, and Lynch syndrome. Nevertheless, the uncertain safety of genetic modification, the risk of organoid application, and bionics of current genetically modified organoids are still challenging. This review summarizes the researches on genetically modified organoids in recent years, and describes the transfection methods and functions of genetically modified organoids, then introduced their applications at length. Also, the limitations and future development directions of genetically modified organoids are included.

Due to the swift advancement of the electronic industry and information technology, electromagnetic wave absorption materials are gaining significance in the field of intelligent equipment and weaponry. Nanomaterials were developed to investigate wave absorbing materials that can achieve both impedance matching and attenuation balance. Nanomaterials possess the properties of being thin, lightweight, and capable of absorbing microwave radiation across a wide range of frequencies. This work aims to present a systematic overview of the recent advancements in core-shell materials, specifically carbon, oxide, and sulfide nanomaterials, with regards to their applications in electromagnetic absorption and electromagnetic shielding. This review intends to emphasize the core principles of electromagnetic interference (EMI) shielding and microwave absorption in different systems documented in the literature, along with diverse methods of synthesis and fabrication for creating effective wideband electromagnetic absorbers/shields. Lastly, we also endeavor to offer a comprehensive view and insight into the areas where future research will thrive. This study provides a comprehensive assessment of the current advancements in the field of microwave absorption and electromagnetic shielding of nanomaterials.

Bio-inspired superhydrophobic surfaces have demonstrated great potential for functional applications across a wide range of fields, including the surface maintenance of building materials. In the outdoor environment, the degradation of building materials, such as concretes, stones, bricks, tiles and mortars, poses severe structural, functional and aesthetic risks to the entire construction, raising growing concerns worldwide. Superhydrophobic surfaces are ideal multifunctional protective coatings, owing to the inhibition of liquid adhesion/penetration, spontaneous surface self-cleaning and hindering the adhesion of bacterial cells to surfaces. Yet, despite the appealing multi-functionalities and the large number of materials reported in recent years, several drawbacks that hamper wide production and application remain unresolved, e.g., poor chemical/mechanical/weathering durability, low transparency, insufficient antimicrobial effect in humid environments, toxic and environmentally unfriendly raw materials upon fabrication. In this review, the key bottlenecks identified after tentative applications are summarized underlying the underpinning mechanisms in depth. The newly proposed emerging strategies for addressing the specific limitations are then categorized and discussed in detail. Additionally, taking into account the physicochemical properties of building materials, the particular requirements concerning stone-built heritage conservation and the outdoor environment, the feasibility and the pros and cons of novel strategies are critically reviewed, outlining the future prospects of the field.

Chirality is a common phenomenon in nature, including the dominance preference of small biomolecules, the special spatial conformation of biomolecules, and the biological and physiological processes triggered by chirality. The selective chiral recognition of molecules in nature from up-bottom or bottom-up is of great significance for living organisms. Such as the transcription of DNA, the recognition of membrane proteins, and the catalysis of enzymes all involve chiral recognition processes. The selective recognition between these macromolecules is mainly achieved through non covalent interactions such as hydrophobic interactions, ammonia bonding, electrostatic interactions, metal coordination, van der Waals forces, and π-π stacking. Researchers have been committed to studying how to convert this weak non covalent interaction into macroscopic visualization, which has further understood of the interactions between chiral molecules and is of great significance for simulating the interactions between molecules in living organisms. This article reviews several models of chiral recognition mechanisms, the interaction forces involved in the chiral recognition process, and the research progress of chiral recognition mechanisms. The outlook in this review points out that studying chiral recognition interactions provides an important bridge between chiral materials and the life sciences, providing an ideal platform for studying chiral phenomena in biological systems.

Flotation, as a beneficiation process, stands as a foundation in mineral and metal production, handling approximately 70-80 % of the world's exploited ore annually. However, numerous challenges emerge prior to beneficiation, such as the declining quality of ore, necessitating further liberation. This deterioration results in higher energy, water, and reagent consumption. A froth flotation chemicals market analysis reveals an anticipated growth of around 30 % in the next five years, signaling a concerning trend due to the frequent toxicity associated with these chemicals. With increasingly stringent environmental regulations, there is a pressing need to explore more sustainable and non-toxic solutions. Polymers play a significant role in mineral processing as either depressants, flocculants or dispersants. The potential of natural green polymers in these capacities is actively being studied. This review delves into the relatively novel use of polymers as collectors, examining their performance and adsorption mechanisms. Among the papers reviewed, collectors formulations based on either natural or synthetic non-toxic polymers have emerged as environmentally friendly alternatives to traditional collectors. The utilization of polymers opens possibilities for creating nanoparticles, conventional polymers, temperature-responsive polymers and block copolymers with functionalities tailored for specific separation processes. These polymers have shown promising results, achieving recoveries and grades comparable to or better than conventional collectors. Additionally, they could address the challenge of declining ore quality, effectively handling finely ground particles and slimes. Properties such as those in temperature-responsive polymers can be used not only to induce hydrophobicity but also to allow the recycling of the collector for future applications.

Spanlastics, which are commonly referred to as elastic niosomes, presents a modified advancement in the area of colloidal system based drug delivery carriers. They are different from niosomes, which are non-ionic surfactant vesicles in having an edge activator. Initially, they were described as ocular drug delivery systems in 2011 by Kakkar and Kaur. Spanlastics have discovered a wide range of applications via different routes of administration. The purpose of this article is to provide information about spanlastics, a newly developed drug delivery system for the management of diseases pertaining to the Central Nervous System (CNS) via intranasal route. The article begins with the details on spanlastics and their composition, their benefits over traditional niosomes, and the mechanism underlying their enhanced absorption. Their applications through various routes of administration in a variety of diseases for a variety of drugs have been discussed. Furthermore, the article explains the nose to brain delivery channels and the advantages that this route offers over conventional delivery routes. Finally, the article discusses the studies encompassing the drug candidates that have been formulated as intranasal spanlastics for the management of different diseased conditions along with the future prospects of this emerging drug delivery system.

The application of curcumin in food science is challenged by its poor water solubility, easy degradation under processing and within the gastrointestinal tract, and poor bioavailability. Micro/nanocarrier is an emerging and efficient platform to overcome these drawbacks. This review focuses on the recent advances in the development and application of curcumin-loaded micro/nanocarriers in food research. The recent development advances of curcumin-loaded micro/nanocarriers could be classified into ten basic systems: emulsions, micelles, dendrimers, hydrogel polymeric particles, polymer nanofibers, polymer inclusion complexes, liposomes, solid lipid particles, structured lipid carriers, and extracellular vesicles. The application advances of curcumin-loaded micro/nanocarriers for food research could be classified into four types: coloring agents, functional active agents, preservation agents, and quality sensors. This review demonstrated that micro/nanocarriers were excellent carriers for the fat-soluble curcumin and the obtained curcumin-loaded micro/nanocarriers had promising application prospects in the field of food science.

Proteins from plant sources including legumes, cereals and oilseeds are gaining attention due to their suitability for sustainable production, functionality, and positive consumer perception. On the other hand, polyphenols (PPs) are receiving considerable attention as natural ingredients in the human diet due to their potent antioxidant and anti-inflammatory properties. Recent studies indicate that the emulsifying properties of plant proteins (PLPs) can be improved after modification through covalent and/or non-covalent interactions with PPs due to the changes in the conformation and/or the surface chemistry of the proteins. Complexes formed between PLPs-PPs can serve as innovative ingredients for developing novel food products with modified textural properties. Also, Pickering emulsions, multiple emulsions, multilayer emulsions, nanoemulsions, and high internal phase emulsions can be stabilized by such systems to deliver bioactive compounds. This paper reviews the most recent research on the PLP-PP interactions and their role in the stabilization of various emulsion-based systems. A special emphasis is given to modifying the structure and functionality of PLPs and PPs. The challenges and opportunities of applying PLP-PP interactions in emulsion-based systems are also highlighted.

Advances in polymer science have led to the development of semi-interpenetrated and interpenetrated networks (SIPN/IPN). The interpenetration procedure allows enhancing several important properties of a polymeric material, including mechanical properties, swelling capability, stimulus-sensitive response, and biological performance, among others. More interestingly, the interpenetration (or semi-interpenetration) can be achieved independent of the material size, that is at the macroscopic, microscopic, or nanometric scale. SIPN/IPN have been used for a wide range of applications, especially in the biomedical field, including tissue engineering, delivery of chemical compounds or biological macromolecules, and multifunctional systems as theragnostic platforms. In the last years, this fascinating field has gained a great interest in the area of polymers for therapeutics; therefore, a comprehensive revision of the topic is timely. In this review, we describe in detail the most relevant synthetic approaches to fabricate polymeric IPN and SIPN, ranging from nanoscale to macroscale. The advantages of typical synthetic methods are analyzed, as well as novel and promising trends in the field of advanced material fabrication. Furthermore, the characterization techniques employed for these materials are summarized from physicochemical, thermal, mechanical, and biological perspectives. The applications of novel (semi-)interpenetrated structures are discussed with a focus on drug delivery, tissue engineering, and regenerative medicine, as well as combinations thereof.

Metal organic frameworks (MOFs) are porous coordination polymers with adjustable nanostructure, high porosity and large surface areas. These features make MOFs, their derivates and composites all delivered remarkable potential in energy and environmental fields, such as rechargeable batteries, supercapacitors, catalysts, water purification and desalination, gas treatment, toxic matter degradation, etc. In particular, one-dimensional (1D) MOFs have generated extensive attention due to their unique 1D nanostructures. To prepare 1D MOF nanostructures, it is necessary to explore and enhance synthesis routes. In this review, the preparation of 1D MOF materials and their recent process applied in energy and environmental fields will be discussed. The relationship between MOFs' 1D morphologies and the properties in their applications will also be analyzed. Finally, we will also summary and make perspectives about the future development of 1D MOFs in fabrication and applications in energy and environmental fields.

Understanding the mechanisms underlying the dispersion and digestion process is vital in the development of oral lipid-based formulations (LBFs). In vitro lipolysis models mimic the digestion process in the stomach and intestine to explore the fundamental mechanism of supersaturation, solubilization, and precipitation of drugs within the LBFs. The lipid digestion is controlled by the in vitro experimental conditions, and constitution of the lipid formulations. Hence, there is a continuous upgradation in the digestion models to best extrapolate the in vivo conditions. This review covers the recent developments in digestion models with media compositions and lipid formulation components. Key findings from recent studies that thoroughly examined the relation between the digestion, solubilization, and permeation of oral LBFs in the presence of bile-lipid aggregates are presented. These developments are foremost to build the in vitro-in vivo correlation of the drugs for regulatory considerations.