JACC-Cardiovascular Imaging

Cancer and the Heart: What Do We Really Know About Imaging?
Thavendiranathan P and Chandrashekhar Y
Impact of Bariatric Surgery on Coronary Microvascular Function: When Lower Weight Means Better Flow!
Poirier P
Improving Precision and Refining Risk Prediction of CTRCD With Cardiovascular CT
Parwani PJ and Lopez-Mattei J
Mechanism and Impact of Left Atrial Dyssynchrony on Long-Term Clinical Outcome During Cardiac Resynchronization Therapy
Hammersboen LR, Stugaard M, Puvrez A, Larsen CK, Remme EW, Kongsgård E, Duchenne J, Galli E, Khan FH, Sletten OJ, Penicka M, Donal E, Voigt JU, Smiseth OA and Aalen JM
Left bundle branch block (LBBB) causes left atrial (LA) dyssynchrony. It is unknown if LA dyssynchrony impacts long-term prognosis.
Evolving Approaches for Diagnostic Testing in Suspected Coronary Artery Disease
Shaw LJ and Chandrashekhar YS
Stress CMR Perfusion Imaging in the Medicare-Eligible Population: Insights From the SPINS Study
Ge Y, Antiochos P, Bernhard B, Heydari B, Steel K, Bingham S, Mikolich JR, Arai AE, Bandettini WP, Patel AR, Shanbhag SM, Farzaneh-Far A, Heitner JF, Shenoy C, Leung SW, Gonzalez JA, Shah DJ, Raman SV, Ferrari VA, Schulz-Menger J, Stuber M, Simonetti OP and Kwong RY
Patients aged ≥65 years account for a disproportionately large portion of cardiovascular (CV) events and pose a challenge for noninvasive detection of coronary artery disease.
Echocardiographic Evaluation of Chronic Aortic Regurgitation: Comparison With Cardiac Magnetic Resonance and Implications for Guideline Recommendations
Attar R, Malahfji M, Angulo C, Nguyen DT, Graviss EA, Shah DJ and Zoghbi WA
Guidelines for echocardiographic evaluation of aortic regurgitation (AR) have not been validated against an independent quantitative standard.
Timing of Regadenoson-Induced Peak Hyperemia and the Effects on Coronary Flow Reserve
Kattapuram N, Shadman S, Morgan EE, Benton C, Awojoodu S, Kim DY, Ramos J, Barac A, Bandettini WP, Kellman P, Weissman G and Carlsson M
Cholesterol, Atherosclerotic, and Inflammatory Risks Among Patients With Statin Therapy
Dai N, Hu Y, Tang X, Guo W, Guo Z, Zhou F, Zhang L, Prakash Edavi P, Lu H, Qian J and Ge J
Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial
Kolossváry M, Lin A, Kwiecinski J, Cadet S, Slomka PJ, Newby DE, Dweck MR, Williams MC and Dey D
Coronary computed tomography (CT) angiography-derived attenuation-based plaque burden assessments can identify patients at risk of myocardial infarction.
Parsing the Shades of Gray of Myocardial Fibrosis in Aortic Stenosis
Wang TKM and Dong T
Calcium Scoring and Plaque Density: Room for Improvement
Bhatia HS
Echocardiographic Markers of Early Left Ventricular Dysfunction in Asymptomatic Aortic Regurgitation: Is It Time to Change the Guidelines?
Anand V, Michelena HI, Scott CG, Lee AT, Rigolin VH, Pislaru SV, Kane GC, Crestanello JA and Pellikka PA
The ideal timing for surgery in asymptomatic chronic aortic regurgitation (AR) remains unclear. New thresholds for left ventricular ejection fraction (LVEF), left ventricular (LV) indexed end-systolic volume (iESV), and global longitudinal strain (GLS) have been associated with mortality in these patients. These represent markers of early LV dysfunction.
Calcification vs Inflammation: The Modern Toolkit for Cardiovascular Risk Assessment
Antoniades C and Chan K
Looking Beyond Stenosis: The Emerging Role of Cardiac CT in Unveiling Microvascular Dysfunction
Ihdayhid AR and Gahungu N
Myocardial Blood Flow Quantification Using Stress Cardiac Magnetic Resonance Improves Detection of Coronary Artery Disease
Wang S, Kim P, Wang H, Ng MY, Arai AE, Singh A, Mushtaq S, Sin TH, Tada Y, Hillier E, Jin R, Mariager CØ, Salerno M, Pontone G, Urmeneta Ulloa J, Saeed IM, Patel H, Goh V, Madsen S, Kim WY, Singram Krishnam M, Martínez de Vega V, Maceira AM, Monmeneu JV, Pazhenkottil AP, Amir-Khalili A, Benovoy M, Friedrich S, Janich MA, Friedrich MG and Patel AR
Myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using stress cardiovascular magnetic resonance (CMR) have been shown to identify epicardial coronary artery disease. However, comparative analysis between quantitative perfusion and conventional qualitative assessment (QA) remains limited.
High-Gradient Aortic Stenosis With Valve Area >1.0 cm: The "Forgotten" Discordant Hemodynamic Phenotype
Ito S, Oh JK, Michelena HI, Egbe AC, Connolly HM, Pellikka PA, Nkomo VT, Lewis BR and Miranda WR
Clinical features and outcomes in severe aortic stenosis (AS) have been described according to the hemodynamic phenotypes.
Deep Learning Model of Diastolic Dysfunction Risk Stratifies the Progression of Early-Stage Aortic Stenosis
Tokodi M, Shah R, Jamthikar A, Craig N, Hamirani Y, Casaclang-Verzosa G, Hahn RT, Dweck MR, Pibarot P, Yanamala N and Sengupta PP
The development and progression of aortic stenosis (AS) from aortic valve (AV) sclerosis is highly variable and difficult to predict.
Diffuse Interstitial Fibrosis of the Myocardium Predicts Outcome in Moderate and Asymptomatic Severe Aortic Stenosis
Lee HJ, Singh A, Lim J, Craig N, Bing R, Tastet L, Park JB, Kim HK, Kim YJ, Clavel MA, Gerber BL, McCann GP, Dweck MR, Pibarot P and Lee SP
Patients with moderate or asymptomatic severe aortic stenosis (AS) are at risk of cardiovascular events.
Right Ventricular Systolic Strain Reference Ranges Across Contemporary Vendor-Neutral Echocardiography Software in Healthy Patients
Haroun E, Agrawal A, El Dahdah J, Dong T, Arockiam AD, Majid M, Sorathia S, Grimm RA, Rodriguez LL, Popovic ZB, Griffin BP and Wang TKM
Myocardial Strain Imaging: Theory, Current Practice, and the Future
Smiseth OA, Rider O, Cvijic M, Valkovič L, Remme EW and Voigt JU
Myocardial strain imaging by echocardiography or cardiac magnetic resonance (CMR) is a powerful method to diagnose cardiac disease. Strain imaging provides measures of myocardial shortening, thickening, and lengthening and can be applied to any cardiac chamber. Left ventricular (LV) global longitudinal strain by speckle-tracking echocardiography is the most widely used clinical strain parameter. Several CMR-based modalities are available and are ready to be implemented clinically. Clinical applications of strain include global longitudinal strain as a more sensitive method than ejection fraction for diagnosing mild systolic dysfunction. This applies to patients suspected of having heart failure with normal LV ejection fraction, to early systolic dysfunction in valvular disease, and when monitoring myocardial function during cancer chemotherapy. Segmental LV strain maps provide diagnostic clues in specific cardiomyopathies, when evaluating LV dyssynchrony and ischemic dysfunction. Strain imaging is a promising modality to quantify right ventricular function. Left atrial strain may be used to evaluate LV diastolic function and filling pressure.