Lancet Respiratory Medicine

Elucidating the outpatient burden of RSV disease in children
Dawood FS and McMorrow ML
Burden of RSV infections among young children in primary care: a prospective cohort study in five European countries (2021-23)
Hak SF, Sankatsing VDV, Wildenbeest JG, Venekamp RP, Casini B, Rizzo C, Bangert M, Van Brusselen D, Button E, Garcés-Sánchez M, Vera CG, Kramer R, de Lusignan S, Raes M, Meijer A, Paget J, van Summeren J and
The majority of respiratory syncytial virus (RSV) infections in young children are managed in primary care, however, the disease burden in this setting remains poorly defined.
Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study
Xu JF, Zheng HZ, Lu HW, Wang LW, Wu B, Lv XD, Luo H, Feng J, Li YY, Liu L, Jia JG, Mo WQ, Gu HY, Jiang JB, Wang DX, Wang B, Li L, Yuan Z, Li W, Xie M, Jie ZJ, Fan XY, Li D, Tian X, Zhang M, Guan WJ, Fan H, Song YL, He J, Chu DJ, Du CL, Zhang JQ, Cao C, Qu JM, Chalmers JD and
Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinical characteristics of patients with bronchiectasis in China.
Social and environmental determinants of health inequities in childhood asthma
Alsulami S and Phipatanakul W
Stubble: the Farmer's Bane
Burki T
Bronchiectasis in China: increasing awareness and action
Huang K and Yang T
Vaccine policy experts concerned about second Trump Administration
Furlow B
Respiratory research funding: consequences of neglect
The Lancet Respiratory Medicine
Chronic cough as a disease: implications for practice, research, and health care
Chung KF, Mazzone SB, McGarvey L and Song WJ
PRGN-2012 gene therapy in adults with recurrent respiratory papillomatosis: a pivotal phase 1/2 clinical trial
Norberg SM, Valdez J, Napier S, Kenyon M, Ferraro E, Wheatley M, Parsons-Wandell L, Doran SL, Lankford A, Sabzevari H, Brough DE, Schlom J, Gulley JL and Allen CT
Recurrent respiratory papillomatosis (RRP) is a rare debilitating condition caused by chronic infection with human papillomavirus (HPV) type 6 or 11. Papillomas develop in the aerodigestive tract, leading to significant voice disturbance and airway obstruction. No systemic treatment currently exists. We aimed to assess the safety and clinical activity of PRGN-2012 in adult patients with RRP treated at the recommended phase 2 dose.
A high-impact study and landmark achievement in the treatment of recurrent respiratory papillomatosis
Derkay CS
A response to therapy for COPD with dupilumab
Bhatt SP, Rabe KF, Singh D, Bafadhel M and Vogelmeier CF
What does the expanding CFTR modulator programme mean for people with cystic fibrosis?
Southern KW
Incorrect interpretation of the role of COVID-19 vaccination boosters in saving lives
De Bie T
Incorrect interpretation of the role of COVID-19 vaccination boosters in saving lives - Authors' reply
Meslé MMI, Brown J, Widdowson MA and Pebody RG
Population-based cancer registries: an essential partner in monitoring and establishing critical action points
Burki T
The UK Tobacco and Vapes Bill: a historic opportunity
The Lancet Respiratory Medicine
On the front lines of the sepsis crisis: hurdles faced by sepsis researchers, survivors, and family advocates
Duda J
Collateral caring
Wu H
Vanzacaftor-tezacaftor-deutivacaftor versus elexacaftor-tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials
Keating C, Yonker LM, Vermeulen F, Prais D, Linnemann RW, Trimble A, Kotsimbos T, Mermis J, Braun AT, O'Carroll M, Sutharsan S, Ramsey B, Mall MA, Taylor-Cousar JL, McKone EF, Tullis E, Floreth T, Michelson P, Sosnay PR, Nair N, Zahigian R, Martin H, Ahluwalia N, Lam A and Horsley A
The goal of cystic fibrosis transmembrane conductance regulator (CFTR) modulators is to reach normal CFTR function in people with cystic fibrosis. Vanzacaftor-tezacaftor-deutivacaftor restored CFTR function in vitro and in phase 2 trials in participants aged 18 years and older resulting in improvements in CFTR function, as measured by sweat chloride concentrations and lung function as measured by spirometry. We aimed to evaluate the efficacy and safety of vanzacaftor-tezacaftor-deutivacaftor compared with standard of care elexacaftor-tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years and older.
Vanzacaftor-tezacaftor-deutivacaftor for children aged 6-11 years with cystic fibrosis (RIDGELINE Trial VX21-121-105): an analysis from a single-arm, phase 3 trial
Hoppe JE, Kasi AS, Pittman JE, Jensen R, Thia LP, Robinson P, Tirakitsoontorn P, Ramsey B, Mall MA, Taylor-Cousar JL, McKone EF, Tullis E, Salinas DB, Zhu J, Chen YC, Rodriguez-Romero V, Sosnay PR and Davies G
In phase 2 trials in people with cystic fibrosis aged 18 years and older, vanzacaftor-tezacaftor-deutivacaftor has been shown to be a safe and effective, once-daily cystic fibrosis transmembrane conductance regulator (CFTR) modulator. Restoring normal CFTR function early in life has the potential to prevent manifestations of cystic fibrosis. We aimed to evaluate the safety, tolerability, efficacy, and pharmacokinetics of vanzacaftor-tezacaftor-deutivacaftor in children with cystic fibrosis aged 6-11 years.