Measures of complex functional decision-making capacity can greatly aid in assessing mild cognitive impairment (MCI) and facilitating early intervention in dementia care. We examined the ability of the Assessment of Functional Capacity Interview (AFCI) to detect functional differences among older adults who were cognitively unimpaired (CU), or who presented with subjective cognitive decline (SCD) or MCI. A sample of 97 older adults (CU; n = 30, Mage = 74.64 ± 7.42 years; SCD; n = 34, Mage = 72.56 ± 6.43 years; MCI; n = 33, Mage = 78.28 ± 7.55 years) underwent neuropsychological testing and responded to the Financial Capacity Instrument (FCI-SF). Informants completed the Assessment of Functional Capacity (AFCI), an instrument of functional decision-making capacity, and responded to the Social Vulnerability Scale (SVS15) and Amsterdam Instrumental Activity of Daily Living (A-IADL-Q-SV), a measure of functional status, for comparison. According to informant-reported responses, the CU group had significantly lower AFCI total (and domain) scores, (2) = 27.59, <.001, relative to MCI. Additionally, the CU group had significantly lower AFCI scores in the domain relative to the SCD group, (2) = 14.06, <.05. In the overall sample, AFCI total scores were associated with FCI-SF, SVS15, and A-IADL-Q-SV scores and cognitive measures. Our results demonstrate that the AFCI is sensitive to impairment in safety, social, financial, and medical functioning in MCI and is associated with measures of cognitive functioning and social vulnerability in older adults. Incorporating this instrument as a supplement to cognitive screening instruments may aid in the prevention of hazardous decision-making in older adults.

Though previous research yielded inconsistent results, studies suggest an association between frontal alpha asymmetry (FAA), mood, and self-regulation. This inconsistency may be explained by the heterogeneity of experimental protocols and sample characteristics such as the baseline level of distress. The aim of the study was to gain a better understanding of the relationship between FAA and self-report measurements of depression, anxiety, stress, and self-regulation. Using data from 130 participants (M = 25.2; SD = 6.8), we conducted correlation analyses and Bayesian statistics to examine these associations. The results revealed moderate-level positive correlations among depression, anxiety, and stress scores measured by the Depression Anxiety Stress Scale, with notable negative correlations observed between self-regulation and depression, as well as between self-regulation and stress. The relationship between FAA and mood was sample-dependent, and effects were restricted to the sample with moderate to extreme levels of distress, revealing consistent patterns within these subgroups. Most importantly, there was a negative correlation between FAA and anxiety. However, there was no clear association between FAA and depression. Consequently, our results show that self-regulation is associated with reduced distress, and that FAA may be a useful biomarker for anxiety in individuals with moderate to high baseline distress levels.

The term "brain fog" has emerged from the observations of neuropsychiatric conditions present in post-COVID-19 infections. This is characterized by concentration and memory problems, selective attention disorders and difficulties in executive functions, yet it is unclear how long these deficits may persist and which cognitive functions are most vulnerable. Therefore, there is a need to properly evaluate these cognitive complaints using an assessment tool that specifies their intensity and nature. Our primary objective was to explore subjective perceptions of cognitive functioning in COVID-19-associated with brain fog using a tool that was previously validated for assessing subjective cognitive complaints. A total of 68 participants were recruited and the Subjective Scale to Investigate Cognition (SSTICS) was used to assess cognitive complaints. This was the first time that the SSTICS was used for this purpose in subjects with COVID-19. In addition, participants were administered a questionnaire assessing for the presence of various symptoms, as well as COVID-19 clinical parameters. The neuropsychological basis for the construct of the SSTICS was related to the cognitive complaints expressed by participants. A reliability analysis of our sample indicated a high degree of internal consistency (Cronbach's alpha= 0.951). Associations between various SSTICS scores and COVID-related symptomatology and the differences between group of participants who reported cognitive complaints ("complainers") and those who did not were assessed. We performed an exploratory factorial analysis based on Principal Component Analysis (PCA). Based on their distribution, participants were grouped into: "good functioning" - scores 0-9 (35.3%); "medium functioning" - scores 14-23 (25%); and "poor functioning" - scores 26-71 (39.7%). The mean SSTICS score was 20.59 (SD 16.61) and correlated with the quarantine duration and loss of smell. Complainers differed significantly from non-complainers in the total number of symptoms, the quarantine duration and the presence/absence of specific symptoms, such as loss of smell, tiredness and aches/pains. Our study showed that >10% of patients reported subjective cognitive complaints following COVID-19, with most reporting mild or serious cognitive complaints, mostly within the domains of memory, attention, language, executive functioning or praxis.

This study aims to assess whether electroencephalogram (EEG) spectral power change scores (e.g. task spectral power subtracted from resting state spectral power) across three different frequency bands, alpha (8-12 Hz), theta (4-7 Hz), and beta (13-30 Hz), predicts self-reported attention-deficit hyperactivity disorder (ADHD) symptoms using the Adult ADHD Self-Report Scale (ASRS) over and above self-reported executive function (EF) abilities using the Behavior Rating Inventory of Executive Function (BRIEF-A) Global Executive Composite (GEC) T-scores for adults.

To evaluate the cerebellar cognitive affective syndrome scale (CCAS-S) in patients with acute cerebellar stroke (ACS) and examine its relationship with the discharge destination.

The current study was conducted with the aim of evaluating the third version of Addenbrooke's Cognitive Examination (ACE-III), and exploring its diagnostic power for a sample of stroke patients in the Iranian population. This was a cross-sectional analytical study, in which 206 patients with stroke were compared with 200 normal individuals as the control group. The patients were diagnosed based on the findings of neuroimaging and clinical examination by a neurologist. ACE-III, Montreal Cognitive Assessment (MoCA), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), and The Structured Clinical Interview for DSM-5 (SCID-5) were used to gather the data and assess the vascular dementia in the patients. Furthermore, Cronbach's alpha, Pearson correlation coefficient, discriminant function analysis, and the receiver operating characteristic (ROC) curve were used to respectively measure internal consistency, convergent validity, discriminant validity, sensitivity, specificity, and the cutoff point of ACE-III. Internal consistency of ACE-III was excellent (α = 0.92 - 0.95), and convergent validity was measured through calculating the correlation between the scores of ACE-III and MoCA, which was very high (r = 0.957, P < 0.0001). Moreover, overall classification accuracy of ACE-III revealed that it is able to differentiate 87% of patients with vascular dementia from other patients. The area under the ROC curve was found to be 0.84, and cutoff point was 45/46, at which sensitivity and specificity were obtained as 0.72 and 0.90, respectively. ACE-III is a rapid, inexpensive, and efficient tool for evaluating cognitive deficits in specialized neurology clinics to provide a clinical and differential diagnosis of vascular dementia after stroke.

This study evaluated the universality of the TOMM 2 and provided a reference sample of cognitively intact adults living in Spain whose native language was Spanish. A total of 203 adults completed the TOMM 2 from June 2019 to January 2020. When using the original TOMM cutoff scores derived from English speakers, all participants scored in a range that would suggest that they passed the TOMM. When using a cut score less than 40 on Trial 1, only one participant in this study would be mistakenly classified as providing an invalid performance. Spanish-speaking adults in Spain from this study achieved a perfect score on Trial 1 at a rate more than double that of English-speaking individuals on the original TOMM. At the item level, all but one item met the minimum standard for performance validity; this item fell only marginally below the standard at 89%. This study found a very low failure rate for the TOMM 2, suggesting that the second edition has at least as high specificity as the original in Spanish adults.

Parkinson's disease (PD) is a neurological disorder that primarily affects movement and is often accompanied by depressive symptoms. Subthalamic nucleus (STN) deep brain stimulation (DBS) has emerged as a therapeutic intervention for PD, although its impact on depressive symptoms remains complex. This study investigates the relationship between PD, DBS, and depressive symptoms, focusing on how DBS influences cognitive function and mood among PD patients in Brazil. The study involved two cohorts: one in 2019 with 46 participants and another in 2022 with 31 patients. Distinct assessment instruments, including the Geriatric Depression Scale-15 and Beck Depression Inventory-II, were employed to evaluate depressive symptoms. The results revealed no significant correlation between participants' gender and the presence of DBS, but substantial differences were observed in age, disease duration, and Activities of Daily Living scores. Patients undergoing DBS showed notably poorer cognitive performance compared to those treated solely with medication. Furthermore, the use of DBS was associated with higher scores on depressive symptoms scales within one of the cohorts. These findings underscore the intricate interplay among PD, DBS treatment, and depressive symptoms, highlighting the necessity for tailored approaches to patient care.

Performance validity tests (PVTs) can be seen as gatekeepers for valid neuropsychological assessment, by marking cognitive test scores that may not reflect true ability levels. The present study explored the significance of repeated validity testing of adults with attention-deficit/hyperactivity disorder (ADHD), by exploring the potential value of performance consistency across assessments. The operational definition of performance consistency was determined by calculating the mean variation in a participant's PVT scores across three separate assessments. Neuropsychological test data of 24 individuals diagnosed with ADHD were complemented by an analogue study involving 69 typically developing individuals who were allocated to either a control group or a simulation group instructed to feign ADHD. All individuals were assessed with embedded and stand-alone PVTs three times with one-month intervals between each assessment. The rate of failed validity testing remained rather stable across assessments. Significant differences in neuropsychological performance scores occurred between individuals with ADHD and experimental simulators, however, mostly nonsignificant effects of small size emerged when considering performance consistency. Our data demonstrate that the consistency of cognitive performance over repeated assessments may be no effective approach to complement validity assessment. Replication is needed in independent research on larger samples.

This study attempted to partially test the hypotheses recently proposed by Spagnolo, Garvey, and Hallett that patients with functional movement disorders (FMDs) should demonstrate impaired performance when presented with tasks that sample affect expression/perception, working memory, and cognitive/motor control. A retrospective chart review of the neuropsychological test performance of 17 adult FMD patients was performed to test these hypotheses. Performance on the Barrow Neurological Institute Screen for Higher Cerebral Functions, the Wechsler Adult Intelligence Scale-Fourth Edition, and the modified version of the Halstead Finger Tapping Test were used to measure these behaviors. Patients with FMD had difficulty performing tasks involving affect expression/perception and working memory relative to other cognitive functions. However, only one-third of the sample demonstrated clinically relevant slow finger tapping speeds. Our findings are consistent with the predictions proposed by Spagnolo et al. that disturbance of affect expression/perception and working memory are common in patients with FMD. However, there was less evidence for consistent disturbances in cognitive/motor control. Exploring what FMD patients experience when performing these tasks may facilitate their awareness of how non-neurological factors may contribute to their symptoms.

Perceived purpose in life (PIL) is linked with many vital health outcomes, including Major Depressive Disorder (MDD).

Individuals recovering from COVID-19 may experience persistent impairment in verbal memory performance, potentially due to illness-related hippocampal injury. Although verbal memory dysfunction is central to schizophrenia, the interactions between this vulnerability and COVID-19 remain unclear, with no imaging studies addressing the issue to-date. To explore this gap and generate hypotheses for future research, we adopted a multiple case study approach. Two pairs of individuals with an ICD-10 diagnosis of schizophrenia were selected, each consisting of one case with a positive COVID-19 anamnesis and one without. We calculated the Reliable Change Index to estimate the clinical significance of verbal memory performance changes, with annualized change rates in hippocampal volumes assessed against normative data. Compared to their matches, COVID-19 positive cases did not show mutually consistent changes in verbal memory performance: one case experienced a significant decline in verbal memory and learning, while the other showed a general normalization of test scores. Left hippocampal volumes showed a comparatively slowed increase, while the right hippocampi decreased in volume, although these atrophy rates did not exceed those expected in general population samples. Based on these findings, we hypothesize that COVID-19 alone does not lead to verbal memory decline in schizophrenia. Instead, the relationship between the diseases may depend on additional factors. Our case pairs differed in body mass index, systolic blood pressure, sex, phase of illness, and whole grey matter volume trajectories, leading us to hypothesize that these variables represent additional predictors or moderators of this relationship.

Reading and writing difficulties are commonly observed after traumatic and non-traumatic brain disorders (T-nTBDs). In this study, we investigated whether: (a) differentiation between acquired dyslexia (AD) and aphasia is possible in patients with T-nTBDs; (b) AD patterns constitute the subtype of Acquired Phonological Dyslexia (APhD); and (c) there are causal interactions between brain lesions and the APhD phenotype. A total of 22 Greek patients with T-nTBDs receiving a six-month intensive speech treatment were recruited for the study. The Western Aphasia Battery (WAB) and the Dyslexia Adults Screening Test (DAST) were applied. The significant statistical correlations between the DAST tests of "Semantic Fluency" and "Nonsense Passage Reading" ( = .006), along with their statistically significant effect on the Dyslexia Quotient ( = .044,  = .020, respectively), highlighted the prevalence of the APhD type. A network of brain lesions was found to be significantly involved in rapid naming, reading, and working memory difficulties. Results indicated that in several patients with T-nTBDs diagnostic APhD patterns potentially different from those of aphasia have been circumscribed and construed by brain lesions involving different but interacting components of the non-lexical route. Such findings are primary as well as decisive for the effective rehabilitation of patients with T-nTBSs.

Mental processes responsible for goal-oriented behavior - executive functioning (EF) - include working memory, flexible thinking, and cognitive control. A reliable and valid assessment of EF can inform appropriate interventions and decisions to drive. We investigated the feasibility and validity of a short, iPad-administered EF screening tool in a non-clinical sample: the Coffs Harbour Executive Functioning Screen (CHEFS). Participants ( = 55) completed the CHEFS alongside a neuropsychological assessment of EF used to assess fitness to drive. Discriminant function analysis (DFA) showed that the CHEFS correctly classified 87% of participants to normative clinical ranges on the Verbal Fluency Test. The results suggest that CHEFS is a novel, easily administered tool for assessing EF in a non-clinical sample. DFA is an appropriate within-tool analysis to support the widespread administration of a screening tool to determine fitness to drive and classify patient referral needs. Further assessment is required to determine CHEFS reliability and validity with a broader range of participants varying in neuropsychological functioning, age, ethnicity, test experience, and compared to on-road driving performance.

This study aims to evaluate the reliability and validity of the Turkish version of the Standard Assessment of Global Everyday Activities (SAGEA) scale in older adults.

In spite of its importance, studies presenting detailed development procedures of alternate forms of verbal memory paradigms remains limited and unclear in terms of word selection criteria, while failing to consider word familiarity factors, despite its crucial role on episodic memory retrieval and encoding mechanisms. The present study aims to present the cross-cultural linguistic adaptation and development procedures of alternate forms of the Free and Cued Selective Reminding Test to the Brazilian context (FCSRT) based on word familiarity. After translation and backtranslation procedures, 231 new words were gathered and underwent a step-by-step familiarity analysis. Initially, overall familiarity feel of each word was assessed through the Familiarity Form (FF) during phase 1, and exposure frequency to words were later assessed through the Familiarity Questionnaire (FQ) completed by healthy controls during phase 2 with the remaining words considered ambiguous in terms of familiarity. Three alternate forms of the FCRST were then developed and assessed in terms of familiarity by the FQ during phase 3, and later administered in healthy control groups during phase 4. Repeated measures analysis revealed no significant differences in terms of familiarity and memory performance among the developed forms. Limitations are discussed, and recommendations are offered for future studies.

Assessment of executive and visuospatial neurocognitive domains is lacking in the Omani population, especially for elderly individuals with low educational levels. Therefore, the Towers of Kuwait-Arabic Neurocognitive Assessment (ToK-ArNA) was developed using similar psychometric features of Tower of London (ToL) test, and the unique architecture of Towers of Kuwait, with the potential to overcome the limitation of ToL color perception difficulties that might be encountered in subjects with hereditary or acquired color vision disorders. We enrolled 120 older Arabic-speaking Omanis from January 2022 to November 2022 and all participants underwent screening to ensure normal cognitive function before performing the ToL and ToK-ArNA tests. Validity, reliability, and non-parametric statistical tests were used for data analysis. A total of 85 participants, 51 men (60%) and 34 women (40%) met the inclusion criteria and completed the testing. Statistical analyses confirmed the validity and reliability of ToK-ArNA compared to ToL, with comparable total Time and Accuracy scores and more preference towered the ToK-ArNA among the participants. Despite the study limitations, these results indicate that the ToK-ArNA is a reliable and applicable executive and visuospatial function assessment tool and further studies are warranted to establish its validity in patients with various neurocognitive disorders.

Recent research and the majority of neuropsychological testing manuals emphasize the importance of establishing a proper relationship between the evaluator and the evaluatee. However, there is relatively little empirical research on this point.

This study investigated Nonword Repetition (NWR) tasks in individuals with Multiple Sclerosis (MS) compared to healthy controls (HC), focusing on phonological working memory (WM). Significant differences were found in NWR acurracy (NWR score between MS subgroups and HC (H = 48.2,  < 0.001). NWR decreased as the number of syllables increased in both groups, indicating increased cognitive load. All MS subtypes showed lower NWR compared to HC across varying syllable lengths (Mann Whitney U Test: two syllables U = 64.5,  < 0.001; three syllables U = 183,  < 0.001; four syllables U = 248,  < 0.001; five syllables U = 283.5,  < 0.001). However, no significant differences were found within MS subtypes based on syllable length. NWR did not differ between mild and severe MS groups. Overall, the NWR test effectively assessed WM in MS, highlighting its utility in diagnosing and addressing language-cognitive challenges in individuals with MS. This underscores the importance of tailored intervention strategies to mitigate these challenges.

Executive functions (EF) decline with age and this decline in older adults with generalised anxiety disorder (GAD) may be influenced by heart rate variability (HRV), brain-derived neurotrophic factor (BDNF), and physical fitness. Understanding these relationships is important for tailored treatments in this population. In this study, 51 adults with GAD ( age = 66.46,  4.08) and 51 healthy controls ( age = 67.67,  = 4.04) were assessed on cognitive inhibition (Stroop task), shifting (Trails part 4), flexibility (Wisconsin Card Sorting Test - Perseverative errors), working memory (Digit Span Backwards), IQ (Wechsler Abbreviated Scale of Intelligence), high frequency HRV, serum mature BDNF levels, and VO max. Results indicated that participants with GAD exhibited better cognitive inhibition compared to controls, with no general reduction in EF. Cognitive inhibition was predicted by gender, HRV, and BDNF levels, while cognitive shifting was predicted by gender and IQ, and cognitive flexibility and working memory by IQ. The enhanced cognitive inhibition in GAD participants might stem from maladaptive use of this function, characteristic of GAD, or protection from EF decline due to normal HRV. Increased BDNF levels, possibly due to good fitness, or compensatory mechanisms related to the disorder, might also play a role. These findings highlight the complexity of EF and related mechanisms in GAD, highlighting the need for interventions that consider both cognitive and physiological factors for optimal outcomes.

Neuropsychological tests (NPTs) are standard tools for assessing cognitive function. These tools can evaluate the cognitive status of a subject, which can be time-consuming and expensive for interpretation. Therefore, this paper aimed to optimize the systematic NPTs by machine learning and develop new classification models for differentiating healthy controls (HC), mild cognitive impairment, and Alzheimer's disease dementia (ADD) among groups of subjects.

The Self-Report Symptom Inventory (SRSI) is a novel tool designed to detect symptom overreporting and other forms of noncredible responding. Unlike existing scales, the SRSI includes genuine and pseudosymptoms scales covering cognitive, affective, motor, pain, and post-traumatic stress disorder domains. The present study aims to investigate the psychometric properties of the Italian Version of the SRSI (SRSI-It), in particular, its factor structure, reliability, convergent and discriminant validity, and diagnostic accuracy. Data from 1180 healthy participants showed a hierarchical structure with higher-order constructs for genuine symptoms and pseudosymptoms, each comprising five subscales. The SRSI-It showed a strong convergent validity with the Structured Inventory of Malingered Symptomatology and discriminant validity through low correlations with the Psychopathic Personality Inventory-Revised. Receiver operating characteristic analysis determined cut scores of 6 (95% specificity) and 9 (98% specificity) for pseudosymptoms, with a Ratio Index score of 0.289 (82% specificity). In summary, the SRSI-It appears to be a promising tool for identifying symptom exaggeration in clinical and forensic contexts, ultimately enhancing the quality and reliability of evaluations in these contexts.

Pre-frontal cortex operates a combination of emotional, cognitive and behavioural functions. Understanding the symptoms of pre-frontal cortex lesions serves as paramount for accurate diagnosis and management.

Demonstrate how patient-level traumatic brain injury (TBI) data from studies in the Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System can be harmonized and pooled to examine relationships between TBI and cognitive functioning.

Using diffusion tensor imaging (DTI), we assessed the extent to which fractional anisotropy values in the dorsal (i.e., arcuate fasciculus; AF) versus ventral (i.e., inferior fronto-occipital fasciculus; IFOF) distinction of structural white matter pathways associated with selected reading processes, could be replicated in skilled adult readers (N = 17) and extended to adults with reading impairments (N = 13). In addition to the AF and IFOF, motor-based tracts (i.e., posterior limb of the internal capsule (PLIC) and the frontal aslant tract (FAT)) were isolated to explore their role in reading performance. Several interesting relationships with reading performance emerged. First, orthographic awareness was related to the left IFOF in skilled readers, whereas orthographic awareness was related to left PLIC for impaired readers. Morphological awareness was related to left FAT for skilled readers, whereas morphological awareness was related to right AF, right IFOF and left PLIC for impaired readers. Overall, these findings support the notion that adult reading performance (both skilled and impaired) is related to the structural properties of the ventral white matter pathways. More consideration should be paid to motor pathways, particularly the PLIC, and their role in compensatory reading strategies in individuals with reading impairments.

Assessing mental health needs among college athletes is important given the frequency of symptoms of depression and anxiety and associated complications that may arise after a sports-related concussion. The purpose of this study was to explore the utility of the General Anxiety Disorder-7 (GAD-7) as an independent measure of anxiety symptoms among Division II collegiate athletes ( = 568) during baseline concussion assessments, which also included the post-concussion symptom scale (PCSS) and a measure of depression, the Patient Health Questionnaire-9 (PHQ-9). While only 31 athletes (5.5%) fell above the established GAD-7 cutoff score of 5 or more, a sizable proportion of them (13 or 41.9%) endorsed 0 items on the PCSS affective symptom cluster. Additionally, ∼2% of athletes reported elevated symptoms of anxiety but not depression. These findings support the incorporation of a brief stand-alone anxiety screening tool during concussion baseline evaluations to ensure better detection of student athletes with elevated anxiety symptoms who might otherwise be overlooked, so they may be referred for further diagnostic assessment.

Detecting malingered neurocognitive dysfunction is a major issue in forensic context, particularly in legal proceeding/insurance assessment after a traumatic brain injury (TBI), condition frequently associated with persistent cognitive impairments that may potentially be related to malingering. Consequently, research has devoted considerable efforts on developing tools to verify symptoms authenticity. This study compared two freestanding performance validity tests (PVTs) (Amsterdam Short-Term Memory Test-ASTM; Word Completion Memory Test-WCMT) and five embedded PVTs (Rey Complex Figure Test-RCFT-Copy and Recall trials; Reliable Digit Span-RDS; Rey Auditory Verbal Learning Test-RAVLT-Recognition and Total Learning trials) in a sample of 120 participants, including 15 patients with TBI ( = 44.40), 52 experimental simulators ( = 29.52) and 53 control ( = 29.77). Group performance was analyzed to assess tests' discriminatory power, and Receiver Operating Characteristic (ROC) curves were used to examine tools' sensitivity and specificity. Results indicated that experimental simulators performance on the ASTM, WCMT, and RAVLT differed significantly from TBI patients and controls. The RDS and RCFT did not discriminate experimental simulators from TBI group. ROC curves analysis reveals that the most accurate tests in this battery for detecting malingering were the ASTM and the RAVLT-Total Learning score. This study offers implications for identifying malingering in medico-legal settings, underscoring the importance of incorporating PVTs into clinical practice.

The study was designed to evaluate the performance validity module of Advanced Clinical Solutions (ACS) against external criterion measures and compare two alternative aggregation methods for its five components.

The results of previous research on the relationship between neuropsychiatric symptoms and cognition in multiple sclerosis (MS) have been mixed. The aim of this systematic review was to examine the evidence on the relationship between neuropsychiatric symptoms and different cognitive domains in adult (≥18 years) MS patients. A literature search was conducted in the Ovid Medline, PsycInfo, Scopus, and Web of Science databases. A total of 4,216 nonduplicate records were identified, and after screening, 37 studies met the inclusion criteria and were included in the systematic review. Higher levels of depressive symptoms were related to deficits in processing speed, verbal memory, executive functions, visuospatial functions, and attention in MS patients. Symptoms of anxiety were not consistently related to any of the cognitive functions, but the relationship to deficits in visual memory received a minimal amount of support. Higher levels of apathy were most clearly associated with impairment in executive functions, but the association with deficits in visuospatial functions, visual memory, working memory, and processing speed was also supported. The results indicate that more neuropsychiatric symptoms, especially depressive symptoms and apathy, are associated with cognitive dysfunction in MS patients. These results can be utilized in the clinical examination and treatment planning of MS patients.

A new model of reserve, the Sensory, Emotional, and Cognitive Reserve (SEC) model, has been recently proposed, but so far this model has not been operationalized in instruments to evaluate the different domains of the reserve. This study introduces the SEC reserve inventory (SECri) along with preliminary data obtained from a study involving 57 adults, aged 35 and older. The SECri assesses the SEC domains using specific proxies: (a) sensory reserve (SR) through sensory acuity and sensory perception proxies; (b) emotional reserve (ER) through life events, resilience, and emotional regulation proxies; and (c) cognitive reserve (CR) through education, occupation, socioeconomic status, bilingualism, leisure activities, and personality traits proxies. Key features of SECri include self- and informant-report forms, fine-grained response scales, and the evaluation of reserve development across the lifespan. Findings on the acceptability, convergent validity between SECri domains and validated tests for the same constructs, internal consistency of each domain, and predictive validity of Montreal Cognitive Assessment scores support further research with this inventory. Future studies should consider determining SECri's psychometric properties in clinical and subclinical conditions to evaluate its prognostic value in cases of neurocognitive decline.