This study aimed to evaluate the effect of placental membrane covering of the omphalocele sac on the healing of giant omphaloceles requiring silo repair that could not be treated primarily.

Kidney retransplantation offers a valuable treatment option for patients who experience graft failure after their initial transplant. There is an increasing number of patients undergoing multiple retransplants. However, the impact of multiple kidney retransplants on post-transplant outcomes remains unclear. This study aimed to assess the association between the number of kidney retransplants and post-transplant outcomes in kidney retransplant recipients.

Over the last decade, the number of simultaneous heart-kidney transplants (SHKTs) has increased dramatically. There are few reports of renal allograft outcomes in these high acuity patients. The goal of the present study was to identify variables that were related to early adverse outcomes (EAOs), including delayed graft function (DGF), primary non-function (PNF), and renal allograft futility (RAF) after SHKTs.

Liver retransplantation (reLT), which is the only treatment for liver graft failure, remains challenging not only because of its technical nature but also because it is performed in high-risk patients.

Vascular thymus transplantation has been explored in animal models but remains untested in humans. Current approaches to congenital athymia involve avascular transplantation of allogeneic thymic tissue, which may delay immune recovery. Building on animal studies, we propose revascularization of thymic tissue in a human model. This case report details about the revascularization of neonatal thymic tissue in an elderly woman with terminal cancer, evaluating revascularization efficacy, rejection risks, and procedural safety over a 3-week period.

Chronic kidney disease (CKD) is a burden on children and their caregivers, especially in advanced stages requiring different renal replacement modalities (peritoneal/hemodialysis and renal transplant). The aim of the study is to measure the health-related quality of life (HRQOL) of children and their caregivers for each renal replacement modality, specifically dialysis and transplant.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily involves synovial joints. During the past decade, disease-modifying antirheumatic drugs and biologic agents have been introduced for the treatment of RA. However, they have limitations, including incomplete treatment response, adverse effects requiring drug withdrawal, fall off in efficacy over time, high cost of biologic agents, and refractory cases. Consequently, there is a need to establish safe and effective advanced therapeutic modalities for RA to overcome the shortcomings of current treatments.

After encephalopathy, epileptic seizures (ES) are the second most common neurologic complication after orthotopic liver transplantation (OLT) and may announce a disabling/fatal neurologic disease.

Data on barriers to live-kidney donation in the rural United States is limited despite its widespread adoption across the country.

An acquired diaphragmatic hernia (ADH) is an uncommon event following pediatric liver transplantation. Pediatric liver transplantation proves effective in prolonging survival and improving quality of life for children with methylmalonic acidemia. Remarkably, there have been no previous reports documenting the occurrence of post-liver transplant ADH in patients diagnosed with methylmalonic acidemia.

Weight management was recommended to have more access to transplantation and improve transplant outcomes after liver transplantation (LT). However, the dose-response relationship between body mass index (BMI) and transplant outcomes has not been clearly defined.

Dipeptidyl peptidase-4 inhibitors (DPP-4i) are antidiabetic drugs known for their minimal side effects and limited drug interaction witih immunosuppressants, making them suitable for patients with diabetes and kidney transplant recipients. However, there is limited real-world information regarding the use of DPP-4 inhibitors in patients with post transplant diabetes mellitus (PTDM).

Vasopressor usage during liver transplant is related to decreased hepatic flow, graft failure, and mortality. We measured plasma Copeptin levels in liver transplant patients based on vasopressor requirements. We hypothesize that preoperative plasma copeptin measurement helps predict the vasopressor infusion requirement during liver transplantation in preoperative evaluation.

T-cell mediated rejection (TCMR) in renal transplantation, although reduced by better immunosuppressants, still impacts graft survival. TCMR responds to methylprednisolone (MPL) in 60% to 70% of cases, with polyclonal anti-T-lymphocyte antibodies (ATGs) used for severe or corticoresistant cases. When ATG is contraindicated, extracorporeal photopheresis (ECP) may be an alternative. ECP involves treating immune cells with 8-methoxypsoralen and ultraviolet-A radiation before reinjection, with effect in various T-cell-mediated and autoimmune diseases. This study included two renal transplant recipients with severe TCMR. Patient 1's creatinine levels were 1.4 mg/dL baseline, 2.2 mg/dL at TCMR diagnosis, and 1.9 mg/dL at ECP initiation. Patient 2's levels were 1 mg/dL baseline, 1.8 mg/dL at diagnosis, and 1.42 mg/dL at ECP initiation. The THERAKOS CELLEX system was used for patient 1, and the OPTIA system was used for patient 2, both with methoxsalen. ECP is highlighted as a viable option for TCMR in renal transplantation when conventional treatments are unsuitable.

Accurately assessing graft volume is crucial for donor and recipient safety in living donor liver transplantation. This can be performed using manual computed tomography volumetry (CTvol) or semiautomated methods (MeVis). We aimed to compare CTvol and MeVis in estimating the actual graft weight during LDLT, and analyse any differences in weight between laparoscopic and open donor hepatectomy.

The potential anti-proteinuric effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) is of special interest in kidney transplantation. Its benefits have been demonstrated in diabetic kidney transplant recipients (KTRs). We analyzed the efficacy and safety of SGLT2i in non-diabetic KTRs collecting clinical and analytical data at baseline and 6 months after the introduction of the drug.

The purpose of this study was to investigate the myocardial protective effect of Xuebijing (XBJ) injection in isolated donor heart preservation based on autophagy and NLRP3 inflammatory pathway, and to provide clues for improving the quality of donor heart preservation in the clinic.

The length of the right renal vein is a crucial vascular factor in kidney transplantation. Its shorter length compared to the left renal vein complicates venous anastomosis. The aim of this article is to review the literature on this topic and provide data from our experience.

We assessed the accuracy of different GFR estimating equations in kidney transplant recipients across diverse racial backgrounds, addressing the previously identified validation gap in multiethnic populations predominantly studied in White cohorts.

The management of anticoagulation and antiplatelet therapy in stage V chronic kidney disease (CKD) patients undergoing renal transplantation remains controversial. Some centers advocate for the use of reversal agents or procoagulants preoperatively, while others suggest that transplantation can proceed safely without halting these treatments. This study aims to evaluate the incidence of hemorrhagic and thrombotic complications in the first 72 hours post-transplant in patients receiving anticoagulant or antiplatelet therapy compared to a control group without such treatments. We conducted a retrospective cohort study involving 168 kidney transplant patients at our center from June 2018 to February 2022, with a follow-up period of 6 months post-transplant. Among these, 147 patients were included: 8.2% were anticoagulated, 16.3% were on antiplatelet therapy, and 75.5% received neither treatment. Patients on anticoagulants or antiplatelets were generally older, had a higher prevalence of cardiovascular history, and experienced longer dialysis times. Anticoagulated patients exhibited longer cold ischemia times and increased rates of hyperimmunization, alongside prolonged hospital stays. The overall incidence of hemorrhagic complications in the first 3 days post-transplant was low across all groups: 9% in the control group, 8.3% in anticoagulated patients, and 8.4% in antiplatelet-treated patients, with no significant differences. Blood transfusion rates were 75% for anticoagulated patients, 62.5% for antiplatelet patients, and 51.7% for controls (P = .214). Renal function at 6 months was similar across groups (P = .477), though acute rejection rates were higher in anticoagulated patients (16.6% vs. 4.2% vs. 2.7%; P = .067). No significant differences were found in hemorrhagic and thrombotic complications among the groups.

The foundation for OPTN policy 8.5.B that allows for en bloc kidney utilization from pediatric donors under <18 kg is unclear. Naturally, kidneys recovered from these donors can be split and transplanted into 2 adult recipients as opposed to only 1 (OPTN policy 8.5.C). Our center universally splits all pediatric donor kidneys. We showed that early eGFR is lower in recipients that receive a kidney from a donor <18 kg (3-month eGFR; 36.3 vs 49.7 mL/min/1.73 m, P = .01), but quickly rebounds with no significant differences thereafter. As such, efforts should be made to revisit the practice of en bloc kidney transplantation from small pediatric donors. Given similar complication rates and outcomes seen at our center between the 2 groups, "splitting first" should be the policy to ensure maximalization of transplant recipients.