ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Neuroimaging correlates of cognitive disorders secondary to electroconvulsive therapy: A systematic review
Hassan J, Péran P and Yrondi A
Electroconvulsive therapy is known as an efficient therapy, which is sometimes recommended for the management of severe and resistant depression. However, ECT is associated with cognitive adverse effects. The study of the neurobiological correlates of the cognitive adverse effects of ECT has been covered in few published reviews. However, these mechanisms have been investigated in an increasing number of studies in recent years, particularly in neuroimaging. This systematic review of the literature focuses on correlates between changes in structural or functional neuroimaging and impairment of cognitive functions during the ECT treatment.
Suicide attempts in Martinique and Reunion Island and appointments no-show
Ndiaye C, Messiah A, Gokalsing E, Lislet N, Gillet C, Rene E, Atwan N, Jehel L and Spodenkiewicz M
Studies on suicidal behaviors in the French overseas territories remain rare. Although mental health resources are limited, some patients identified as being at risk of suicide do not attend the specialist consultations scheduled after identification or screening. Thus, the objective of our study was, firstly to provide a descriptive profile of patients followed up for a suicide attempt in Martinique and Reunion Island, and secondly to explore the risk factors associated with appointments no-show during follow-up.
[On the leads of Pinel, francophone psychiatry shines over the Mediterranean]
El-Hachem C, Dirani E and Bou Khalil R
Early access to post-emergency addiction care: ASAP project
Demina A, Meille V, Petit B, Cannard JF and Trojak B
Sleep apnea syndrome in patients with methadone or buprenorphine
Guillet C, Endomba FT, Aravantinos D, Hussami A, Beye F, Girod JC, Georges M and Aho Glélé LS
This work aimed to assess the association between sleep apnea syndrome (SAS) and opioid substitution treatments (OST) dose/timing of administration in patients receiving methadone or buprenorphine for an opioid use disorder (OUD).
Stigma: Bipolar disorder versus cancer, a first-person account
Milandelle M, Gheysen F and Verdoux H
The author shares her experience as patient and epidemiologist with bipolar disorder and cancer. She explains why stigma was more challenging to bear with bipolar disorder than with cancer. This account also includes the perspective of two psychiatrists who provided her medical care. This paper aims to share a message of hope with patients with psychiatric diseases and offer some thoughts to help to reduce a patient's stigma.
Prevalence of problematic drug use in Martinique in 2006: The NEMO study
Rollier S, Lehoux T, Angerville B, Vaissade L, Lacoste J and Merle S
Substance use disorders are of worldwide public health interest. Local estimates of problematic drug use provide useful indicators to regional public health agencies in developing prevention and treatment programs. The purpose of the current study was to estimate the prevalence of problematic drug use in Martinique.
Serum biomarkers, lifetime substance use and conversion to bipolar disorder
Wirowski N, Lobato AS, Bender LV, Cardoso TA, Mondin TC, Souza LDM, Silva RAD, Oses JP, Wiener CD, Jansen K and Pedrotti Moreira F
The diagnostic conversion of major depressive disorder (MDD) to bipolar disorder (BD) is a topic that is currently the subject of several studies. However, there are few studies that clarify the interaction between conversion, substance use and biomarkers.
Experience of neurofeedback and methylphenidate in children with ADHD
Bousquet E, Kerbage H, Purper-Ouakil D and Fongaro E
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. ADHD is commonly treated with medication, such as methylphenidate, but some families and practitioners prefer psychosocial interventions as first line treatments. Many studies have investigated neurofeedback as a potential non-pharmacological treatment for ADHD yielding contradictory findings regarding its efficiency. Qualitative research on neurofeedback in ADHD is limited and can add valuable information on the acceptability and perceived efficacy among service users. This study aimed to explore the perceptions and experiences of children and adolescents with ADHD regarding the use of neurofeedback and methylphenidate. Eleven interviews with children and their parents explored their subjective experiences and perceived changes. Overall, neurofeedback was negatively experienced by those families: the intervention did not meet their expectations, and they reported minimal observed changes. The treatment with methylphenidate, however, was more manageable for families and was perceived to be more efficient despite its side effects.
CYP2D6 and CYP2C19 ultrarapid metabolisms are associated with suicide attempts in schizophrenia
Korchia T, Faugere M, Tastevin M, Quaranta S, Guilhaumou R, Blin O, Lereclus A, Joober R, Shah J, Palaniyappan L, Lançon C, Fond G and Richieri R
Genetic polymorphisms in genes encoding enzymes metabolizing psychotropics drugs result in various isoenzymes with different catalytic efficacies. Of particular interest, some of these isoenzymes are highly catalytic leading to an ultrarapid metabolism (UM) of their substrate medication, which in turn results in lower medication concentrations and possibly poor clinical outcomes, including a higher risk for suicidal behavior. In this study, we investigate the role of CYP2D6 (metabolizing most antidepressant medications) and CYP2C19 (important in metabolizing antipsychotics) UM isoenzymes on suicidal behavior among a cohort of patients with schizophrenia.
French validation of the Stigma Resistance Scale in a sample of people with psychotic disorders
Gomez S, Attal J, Besson M, Boggero M, Bottai T, Gaubert B, Giordana JY, Masson D, Mora G, Milles-Simonet C, Schandrin A, Simonet B and Lecardeur L
The aim of this study was to translate the Stigma Resistance Scale into French and to examine its psychometric qualities to measure stigma resistance in people with psychotic disorders.
An exploratory study of blind spot bias in psychiatrists: The value of mindfulness and ethical skills'
Macé M, Magisson F and Trousselard M
Psychiatry is an area of medicine that is particularly exposed to the risks of cognitive bias, notably because diagnosis is subjective. However, psychiatrists may develop psycho-cognitive skills that protect against bias, as the reflective approach to their patients favors the activation of system 2 (logical) as opposed to system 1 (intuitive) processes. Furthermore, the collegial practices found in psychiatry, a consequence of the ethical questions psychiatrists must address, can also mitigate the impact of bias. On the other hand, clinical ethics committees have adopted structured deliberation practices that aim to improve collective decision-making and limit the cognitive biases associated with groupthink.
[Which solution to functional somatic disorder: The ACSEPT program]
Moumen C, Rousselle M, Danel J, Vaiva G, Amad A and Horn M
Functional somatic disorder (FSD) is a prevalent disorder that can be severely disabling for the patient and is associated with major health costs. There are few formalized care programs for these disorders in the country, and their management encounters various difficulties, both in the diagnosis and its announcement and the treatment. Cognitive-behavioural and emotional therapy (CBT) is the standard on psychiatry care, and its efficacy has been demonstrated through several randomised controlled studies on the intensity of physical and psychological symptoms.
French national helpline "stop" for minor-attracted persons: First findings
Bellis A, Pinède D, Moulier V, Martin-Bertsch I and Januel D
Preventing minor-attracted persons from acting on their impulses is a significant public health concern. To address this, the STOP telephone helpline was established nationwide in France in January 2021. This service acts as a bridge, connecting callers with their nearest CRIAVS (resource centers for professionals working with sex offenders) where they can speak with a healthcare professional who can guide them toward appropriate care if needed. Our study is a detailed look at the STOP service's activity from January 1st, 2021, to December 31st, 2022, covering a span of 24 months.
[Promoting mental health recovery through metacognitive reflection and insight therapy (MERIT): A systematic literature review]
Violeau L, Valery KM, Waintraub MO, Prouteau A and Lysaker P
To demonstrate the effects of a metacognitive reflection and insight therapy (MERIT) in people suffering from psychiatric disorders.
Psychiatrists' beliefs, awareness, and attitudes toward gender variance: A French cross-sectional study
Lemaitre I, Jurek L and Souiller L
The evolution of knowledge and recommendations concerning transgender health has led to various representations, especially for health professionals, that can influence the medical management of transgender individuals. The main objective of this study was to explore the representation of psychiatrists in France regarding gender variance. The secondary objective was to compare these data based on their characteristics.
Bias related to overweight and obesity among French psychiatrists: Results of a national survey
Sohier L, Ravet MS, Berger-Vergiat A and Iceta S
According to people with a higher weight, physicians are the second most stigmatizing group related to excess weight. As a result of these weight-related biases, the therapeutic relationship with the patient and the quality of care would be negatively affected. In addition, this stigma could negatively impact the clinical practice related to higher weight and avoidance of care.
Validation of the French version of the preschool form of the social responsiveness scale-second edition (SRS-2-P)
Picot MC, Michelon C, Loubersac J and Baghdadli A
To evaluate the psychometric properties of the French form of the preschool social responsiveness scale-2 (SRS-2-P-Fr).
Chronic dextroamphetamine abuse and dementia with Lewy bodies: Case report
Lenoir H, Oquendo B and Rigaud AS
COVID-19 lockdown: Impact on youth mental health using gold standard interviews - Insights and lessons from the CoCo20 study protocol
Revah A, Gindt M, Guivarch J, Fossard O, Metelkina-Fernandez V, Nachon O, Richez A, Askenazy F and Fernandez A
Arabic validation of the Body-Esteem Scale for Adolescents and Adults
Hela R, Bourgou S, Hamza M, Fakhfakh R and Belhadj A
The aim of this study was to validate the questionnaire "Body-Esteem Scale for Adolescents and Adults" (BESAA).
Pharmacological and nutraceutical treatments for borderline personality disorder
Gérolymos C, Boyer L, Masson M and Fond G
[When psychiatrists and neurologists work together: From acute and transient psychotic disorder to autoimmune encephalitis]
Tiercelin H, Mélé N, Todorov L, Pham-Scottez A and Gourevitch R
[Impact of the legalization of recreational cannabis on the risk of psychosis: A systematic review of the literature]
Billion Z and Hein M
Cannabis is the most consumed illicit substance in Europe. Although its sale and use remain generally prohibited, European public policies have evolved in recent years by legalizing cannabis for medical use and considering its legalization for recreational use. However, in the literature there are arguments in favor of a particular relationship between cannabis consumption and the development of psychotic symptoms. Thus, since cannabis consumption tends to increase with legalization, the aim of this review was to investigate the impact of the legalization of cannabis for recreational use on the risk of psychosis in regions of the world already concerned.
Retrospective study of hepatitis C screening and seroprevalence in the GHU Paris
Pham-Scottez A, Dauriac-Le Masson V, Ben Dahman O, Toquin A, Benmostefa A and Hallouche N
The prevalence of hepatitis C virus (HCV) has been estimated to be approximately ten times higher in patients with psychiatric disorders, but European data are rare and only two French studies have recently been published on the subject. Our objective was to determine the HCV screening rate and the prevalence of HCV in adult patients hospitalised in the largest French psychiatric hospital.
Should the French approval of baclofen for alcohol dependence be extended to abstinence maintenance?
Rolland B, Karila L, Franchitto N, Barrault C, Naassila M and
Ever since 2018 France has been the only country to approve the gamma aminobutyric acid type B (GABA-B) receptor agonist baclofen for alcohol dependence. This authorization follows a ten-year period of intensive off-label use during which baclofen was used in doses of up to 300 and even 400mg per day to support the gradual reduction of alcohol consumption in patients suffering from alcohol dependence. However, in international clinical trials, baclofen has mainly been studied to support the maintenance of abstinence. The French use of baclofen was therefore somewhat atypical as it paved the way for drug-supported approaches to reducing alcohol consumption, even before nalmefene was marketed. In line with this specific use of baclofen, approval was granted only for alcohol reduction support. However, a recent Cochrane systematic review and meta-analysis by Agabio et al. found significant efficacy only for abstinence maintenance, while no significant effect was found on alcohol reduction outcomes and no dose-response relationship was identified in the analyses. The safety of baclofen was judged to be good. Based on these substantial new results, the Société française d'alcoologie (SFA) now considers that baclofen should also be approved for the maintenance of abstinence. The extension of approval should not lead to the removal of the initial indication or the possibility of using high doses, as some patients have found this therapeutic regimen particularly useful for them. France, which has been a open skies national laboratory on the use of baclofen in alcohol dependence for over ten years, should let this original therapeutic option available to patients. However, it should update the regulatory framework defining the main conditions of access to treatment for patients based on the latest and highest scientific evidence.
Comments on "Anorexia nervosa: An addiction? Application of the addiction model to eating"
de Oliveira J
Obsessive-compulsive symptoms in dementia: Systematic review with meta-analysis
Peste Martinho F, Ferreira TF, Magalhães D, Felício R and Godinho F
Dementia is a highly prevalent syndrome with various causes, characterized by cognitive deficit in one or more domains, with important impairment of functioning, which frequently presents with neuropsychiatric symptoms that may include obsessive-compulsive symptoms.
Psychological first aid in operation for military healthcare providers : a study on pre-deployment training
Gignoux-Froment F, Saguin E, Gorin C, Daudin M, Annette S, Salomé J, Boutonnet M, Aigle L, Schwartzbrod PÉ, Travers S, Lahutte B and Colas MD
During operational missions, while the management of physical injuries in the field remains the priority, the identification of operational incapacity of psychological origin is necessary as it is equally crucial for the safety of the individual, the group and the mission. The French Military Health Service has developed a Psychological First Aid Training in Operation (PFATO) course based on relational simulations, for military service members. The aim is to identify the early signs of psychological distress in a comrade and to adopt an adapted and protective attitude. PFATO training is also offered to healthcare providers.
Accepting multiple conditions in psychiatry: From comorbidity to multimorbidity
Gauld C, D'Incau E, Espi P, Fourneret P, McGonigal A and Micoulaud-Franchi JA
The concept of multimorbidity in psychiatry refers to the coexistence of multiple health conditions without conceptualizing a central disorder referring to a patient-centered approach that views every diagnosis equally. It emphasizes a shift from focusing on an index disorder to considering interrelated symptoms crucial in psychiatry due to frequent multimorbidity patterns. In clinical practice, multimorbidity guides patient-centered care helping to address the holistic needs of patients and challenging the organization of mental health care. In research, multimorbidity reshapes study outcomes and promotes the development of patient-reported outcome questionnaires, also posing ethical challenges and advocating for the inclusion of multimorbid patients in personalized interventions. Finally, multimorbidity in psychiatry has public health implications aligning with the socioecological systems perspective. This notion aims to improve prognosis, care, and health costs while impacting global mortality and challenging the conceptualization and organization of psychiatric care.