Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression: Effect on Maternal and Infant Birth Outcomes in an Observational Secondary Analysis of NUTRIMUM
One-fifth of women experience antenatal depression. Untreated antenatal depression is associated with increased risk of adverse birth outcomes. This study investigated the effect of broad-spectrum micronutrients (BSM; vitamins and minerals), used to treat antenatal depression (NUTRIMUM trial), on birth outcomes.
Efficacy and Safety of Dose Increase From 40 mg/d to 80 mg/d of Lurasidone in Patients With Schizophrenia: A Post Hoc Analysis of Extension Trial
The primary objective of this study was to evaluate the efficacy and safety of increasing the dose of lurasidone from 40 mg/d to 80 mg/d in patients with schizophrenia.
The Treatment of Iatrogenic Anorgasmia in a Male Patient on Clozapine for Treatment-Resistant Schizophrenia: The Role of Pseudoephedrine
Ischemic Priapism With Therapeutic Serum Concentrations of Psychotropic Medications
Ethics in Psychedelic Science: Promises and Responsibilities
Recurrent Pancreatitis Associated With Atomoxetine Use in a 9-Year-Old Boy: A Case Report
Fluoxetine and Sertraline Inhibit Height Growth and Growth Hormone Signaling During Puberty
The aim of this study was to examine the effect of fluoxetine and sertraline on height growth and insulin-like growth factor-1 (IGF-1) during puberty.
Antipsychotic Polypharmacy in Time Course: Evidence for a Cross-titration Trap
Antipsychotic polypharmacy (APP) is controversial yet applied in 20% of patients with psychotic disorders. We investigated indications for initiating and continuing APP, including the contribution of unfinished cross-titrations.
Aripiprazole-Associated QT Prolongation in a Healthy Study Volunteer: A Case Report and Literature Review
Bipolar Disorder in a Young Adult With Thalassemia Major With Sequential Development of Neuroleptic Malignant Syndrome and Serotonin Syndrome
Ketamine. The Story of Modern Psychiatry's Most Fascinating Molecule
Question: Do You Have Suggestions for Managing a Patient With Bipolar II Disorder, Binge Eating Disorder, and Obesity Who Stops Medications Fearing Weight Gain?
Myocarditis on Clozapine 50 mg/d in a Patient With Parkinson's Disease
Suicidal Ideation and Self-harming Thoughts With Valbenazine Use: A Case Report
Lumbosacral Plexopathy in Clozapine Overdose: A Case Report
Health Alert: Microdose Products Leading to Acute Illness and Hospitalizations Across the United States
Efficacy and Safety of Valbenazine in Elderly and Nonelderly Japanese Patients With Tardive Dyskinesia: A Post Hoc Analysis of the J-KINECT Study
The efficacy and safety of valbenazine, a selective vesicular monoamine transporter 2 inhibitor, has been confirmed for treatment of tardive dyskinesia (TD) in patients aged ≥65 years in non-Asian clinical trials; however, data are lacking in elderly Asian patients. This post hoc analysis of J-KINECT aimed to evaluate the efficacy and safety of valbenazine in elderly Japanese patients with TD.
Buprenorphine-Associated Behavioral and Psychotic Side Effects: A Case Report
Mirtazapine as a Treatment for Adolescent Depression and PTSD in Juvenile Detention Settings: A Case Report
Question: How Should I Switch From One Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) to Another SSRI or SNRI in a Patient With Major Depressive Disorder?
A Case Report and Mini Review on Clozapine Treatment During Chemotherapy: Is it Possible to Manage Neutropenia Successfully With Secondary G-CSF?
High-Dose Propranolol for Severe and Chronic Aggression in Autism Spectrum Disorder: A Pilot, Double-Blind, Placebo-Controlled, Randomized Crossover Study
Despite the use of behavioral interventions and psychotropic medications, many individuals with autism spectrum disorder (ASD) who engage in severe aggression remain refractory to conventional treatment. Propranolol, a beta-blocker, has accumulated much anecdotal evidence as a promising option. However, well-designed studies are rare, and the apprehension about cardiovascular side effects from large doses continues to exist.
Lack of Efficacy of JNJ-18038683 on Cognitive Impairment in Patients With Stable Bipolar Disorder
The serotonin type 7 (5-HT7) receptor is one of 14 5-HT receptors. It has received attention for its possible role in mood disorders and cognition. The 5-HT7 receptor antagonist, JNJ-18038683, has been reported to be effective in rodent models of depression and REM sleep. Also, 5-HT7 receptor blockade has been postulated to be a key component of cognitive enhancement in a number of drugs. Bipolar disorder (BD) usually endures cognitive impairment (CI); however, no treatment for CI in BD has been approved. This study aimed to evaluate the efficacy of JNJ-18038683 to improve the CI of BD compared to a placebo.
Antipsychotic Treatment in People at Clinical High Risk for Psychosis: A Narrative Review of Suggestions for Clinical Practice
The "early intervention" paradigm in psychiatry holds significant promise for preventing psychosis. Recent evidence showed that individuals at clinical high risk for psychosis (CHR-P) with antipsychotic (AP) prescription at baseline have higher psychosis transition rates compared with those without AP, although the underlying cause remains unclear. In this article, we reviewed international guidelines on early intervention in CHR-P people, paying specific attention to clinical recommendations on AP treatment. Then, we comment on these suggestions in the light of recent empirical evidence examining AP prescription in CHR-P populations within "real-world" clinical settings.
Clozapine-Associated Eosinophilia at a Movement Disorders Clinic
Transitioning From a Standard Low-Dose to a Rapid Low-Dose Buprenorphine Initiation in a Hospital Setting-A Case Report
Successful Management of ECT-Resistant Interictal Psychosis With Clozapine: A Case Report
